☆ 3.8 Article

Dried blood spot characterization of sex-based metabolic responses to acute running exercise

ANALYTICAL SCIENCE ADVANCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Shogo Sato et al.

Summary: This study compares and analyzes the global metabolite responses in mouse tissues and serum after acute exercise at different time points, revealing the independent and collective metabolic responses of cells and tissues to timed exercise. The results provide a clear understanding of the production and distribution of time-dependent exercise metabolites and offer insights into the health-promoting benefits of exercise on metabolism.

CELL METABOLISM (2022)

添加到收藏夹

Article Biochemical Research Methods

Automated online dried blood spot sample preparation and detection of anabolic steroid esters for sports drug testing

Jing Jing et al.

Summary: Dried blood spots (DBS) are a valuable sample matrix for routine doping analysis, and a fully automated online DBS preparation and detection method has been developed and validated for screening and quantification of anabolic steroid esters. The method showed linear, precise, and accurate results, with applicable LODs for testosterone laurate and other steroid esters. Analyte stability evaluation demonstrated the applicability of automated DBS analysis in doping control for detection of anabolic steroid esters.

DRUG TESTING AND ANALYSIS (2022)

添加到收藏夹

Article Biochemical Research Methods

Optimizing detection of erythropoietin receptor agonists from dried blood spots for anti-doping application

Carmel E. Heiland et al.

Summary: This study investigated the use of dried blood spots (DBS) as a matrix for doping control and found optimal conditions for detecting prohibited erythropoietin receptor agonists (ERAs) and endogenous erythropoietin (EPO) from DBS. The results showed that 60 μl DBS could detect the main ERAs at concentrations close to the minimum required performance levels (MRPLs) set by WADA for serum/plasma samples. Storage temperature did not affect ERA detection. Compared with urine, DBS showed less variation in the detection of endogenous EPO.

DRUG TESTING AND ANALYSIS (2022)

添加到收藏夹

Article Biochemical Research Methods

Growth hormone isoform testing in capillary dried blood spots: Results from single and multiple dose administration studies and large-scale field collections

Geoffrey D. Miller et al.

Summary: This study aimed to examine the detectability of human growth hormone (GH) use in capillary dried blood spots (DBS). The results showed that GH could be detected in capillary DBS using the isoforms method for 12-24 hours following use. This finding is significant for deterrence and detection of GH abuse.

DRUG TESTING AND ANALYSIS (2022)

添加到收藏夹

Article Physiology

High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive Solutions for Blood Storage

Travis Nemkov et al.

Summary: Red blood cell storage is necessary for transfusion, but it can cause decline in cell function and quality. The development of new additives for storage solutions has been limited. Researchers used a metabolomics technology to rapidly screen and develop novel additives that can improve the quality of stored red blood cells.

FRONTIERS IN PHYSIOLOGY (2022)

添加到收藏夹

Article Biochemical Research Methods

Analysis of dried blood spots is a feasible alternative for detecting ephedrine in doping control

Sara Amalie Solheim et al.

Summary: Dried blood spot (DBS) testing is a fast, easy and minimally invasive method for collecting microvolumes of blood, and it has particular relevance in anti-doping control. This study demonstrates the feasibility of using alternative sampling sites and matrices for ephedrine analysis in DBS testing.

DRUG TESTING AND ANALYSIS (2022)

添加到收藏夹

Article Biochemical Research Methods

Detection of erythropoiesis stimulating agent Luspatercept after administration to healthy volunteers for antidoping purposes

Alexandre Marchand et al.

Summary: This study aimed to evaluate the detectability of luspatercept in serum, dried capillary blood spots, and urine for antidoping purpose. The results showed that luspatercept could be detected at high levels in serum and at lower levels in urine for a long period of time. Hematological parameters analysis was also an effective method for indirect detection.

DRUG TESTING AND ANALYSIS (2022)

添加到收藏夹

Article Health Care Sciences & Services

Cancer-related fatigue mediates the relationships between physical fitness and attendance and quality of life after participation in a clinical exercise program for survivors of cancer

Ryan J. Marker et al.

Summary: This study investigates the effects of exercise on HRQoL in cancer survivors using data from a clinical exercise program. The results show that exercise improves HRQoL by improving physical fitness and reducing CRF.

QUALITY OF LIFE RESEARCH (2022)

添加到收藏夹

Article Physiology

High Intensity Concentric-Eccentric Exercise Under Hypoxia Changes the Blood Metabolome of Trained Athletes

Tobias Duennwald et al.

Summary: This study aimed to investigate alterations in the blood plasma metabolome in response to high intensity concentric-eccentric leg exercise performed at a simulated altitude. Through metabolomics analysis, significant differences were observed in the metabolome immediately after exercise, and some relative metabolite concentrations remained changed on day 8 after exercise.

FRONTIERS IN PHYSIOLOGY (2022)

添加到收藏夹

Review Chemistry, Analytical

Advanced Microsamples: Current Applications and Considerations for Mass Spectrometry-Based Metabolic Phenotyping Pipelines

Jayden Lee Roberts et al.

Summary: Microsamples have important applications in metabolic phenotyping research. Compared to traditional venepuncture sampling, microsamples can be self-administered and overcome many sampling challenges. Although research into metabolic phenotyping of microsamples is still in its infancy, advances in technology have already overcome some common barriers.

SEPARATIONS (2022)

添加到收藏夹

Review Physiology

Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology

Michael H. Lee et al.

Summary: Pulmonary arterial hypertension is an incurable disease characterized by dysregulated metabolism at the cellular level in the pulmonary vasculature and impaired exercise oxygen consumption. The precise interactions between altered pulmonary vascular metabolism and abnormal exercise physiology are relatively unknown.

FRONTIERS IN PHYSIOLOGY (2022)

添加到收藏夹

Article Hematology

Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

Angelo D. Alessandro et al.

Summary: Storage of red blood cells in the blood bank leads to metabolic alterations that affect their ability to resist oxidative stress, with donor characteristics such as sex, age, ethnicity, additive solution type, and glucose-6-phosphate dehydrogenase status influencing the metabolism and susceptibility to hemolysis of stored erythrocytes following oxidative insults. Metabolomic markers of hemolysis and glucose-6-phosphate dehydrogenase deficiency were identified, revealing dysregulation in detoxification pathways of oxidized lipids in extreme oxidative hemolysis.

HAEMATOLOGICA (2021)

添加到收藏夹

Article Physiology

Physiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes

Daniela Schranner et al.

Summary: The study found that natural bodybuilders and endurance athletes have different blood metabolite concentrations, ratios, and sums at rest and after exercise, while sprinters are more similar to untrained controls. Endurance athletes have higher metabolite ratios indicating increased activity of carnitine-palmitoyl-transferase I.

PHYSIOLOGICAL REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling

Travis Nemkov et al.

Summary: A controlled, high-intensity cycling test resulted in decreased RBC deformability, increased microparticle generation, oxidative stress, and activation of membrane lipid remodeling mechanisms. Metabolites involved in CoA synthesis and carnitine conversion were significantly correlated with RBC properties during exercise.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Neurosciences

The anaerobic threshold: 50+years of controversy

David C. Poole et al.

Summary: The anaerobic threshold (AT) is a controversial concept in exercise physiology and medicine, originally thought to be caused by muscle anoxia but now understood to be a response to increased glycolytic flux. Lactate is now appreciated as an important energy source and signaling molecule, with non-invasive estimation of LT using the gas exchange threshold remaining important in exercise training and in the clinic.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics

Camilla Marasca et al.

Summary: This study explores the potential of using solid supports and devices for blood microsampling and untargeted lipidomic profiling, with VAMS being identified as a viable option that offers advantages such as independence from hematocrit.

MOLECULES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Blood donor exposome and impact of common drugs on red blood cell metabolism

Travis Nemkov et al.

Summary: Computational models suggest that mature erythrocytes may be affected by common drugs. High-throughput drug screenings show that many drugs impact erythrocyte metabolism, with machine learning models accurately predicting these effects. Certain drugs like ranitidine can improve erythrocyte metabolism and storage quality, indicating potential for enhancing blood transfusion outcomes.

JCI INSIGHT (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Eccentric Cycling Training Improves Erythrocyte Antioxidant and Oxygen Releasing Capacity Associated with Enhanced Anaerobic Glycolysis and Intracellular Acidosis

Yu-Chieh Huang et al.

Summary: This study explores the impact of eccentric cycling training (ECT) on erythrocyte antioxidative capacity and metabolism in sedentary males. The results indicate that ECT enhances antioxidative capacity, promotes oxygen release, and mitigates oxidative stress induced by exercise, suggesting the beneficial effects of ECT on overall health and performance.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrating Whole Blood Transcriptomic Collection Procedures Into the Current Anti-Doping Testing System, Including Long-Term Storage and Re-Testing of Anti-Doping Samples

Giscard Lima et al.

Summary: The study showed that whole blood in long-term and short-term storage without RNA preservation can still be used for gene expression analysis, indicating that transcriptomic analysis of anti-doping samples collected or biobanked without RNA preservation is feasible.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

添加到收藏夹

Article Hematology

Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality

Tiffany Thomas et al.

Summary: The study found that fatty acid desaturases are present and active in mature RBCs, and their activity is sensitive to oxidant stress, storage duration, and alterations of the pyruvate/lactate ratio.

TRANSFUSION (2021)

添加到收藏夹

Article Biochemical Research Methods

Bridging the Polar and Hydrophobic Metabolome in Single-Run Untargeted Liquid Chromatography-Mass Spectrometry Dried Blood Spot Metabolomics for Clinical Purposes

Hanne Bendiksen Skogvold et al.

Summary: A single LC-MS method was developed for DBS metabolite analysis in clinical applications such as newborn screening, allowing for simultaneous analysis of a wide range of metabolites. The method utilized a diphenyl column, a multi-linear solvent gradient, and tailored MS settings to enhance sensitivity and reproducibility for diverse metabolites. The performance of the method was suitable for both untargeted and targeted approaches in clinically relevant experiments.

JOURNAL OF PROTEOME RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Molecular Choreography of Acute Exercise

Kevin Contrepois et al.

CELL (2020)

添加到收藏夹

Article Hematology

Stored RBC metabolism as a function of caffeine levels

Angelo D'Alessandro et al.

TRANSFUSION (2020)

添加到收藏夹

Article Hematology

Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers

Davide Stefanoni et al.

TRANSFUSION (2020)

添加到收藏夹

Review Hospitality, Leisure, Sport & Tourism

Exercise-induced oxidative stress: Friend or foe?

Scott K. Powers et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

添加到收藏夹

Article Physiology

Metabolomics of Endurance Capacity in World Tour Professional Cyclists

Inigo San-Millan et al.

FRONTIERS IN PHYSIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise

Anita Reddy et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Running on Empty: A Metabolomics Approach to Investigating Changing Energy Metabolism during Fasted Exercise and Rest

Gavin Blackburn et al.

METABOLITES (2020)

添加到收藏夹

Article Cell Biology

Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans

Thomas Morville et al.

CELL REPORTS (2020)

添加到收藏夹

Review Public, Environmental & Occupational Health

Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities

Gonzalo J. Domingo et al.

INTERNATIONAL HEALTH (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Sedentary Behavior, Exercise, and Cardiovascular Health

Carl J. Lavie et al.

CIRCULATION RESEARCH (2019)

添加到收藏夹

Article Hematology

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Travis Nemkov et al.

HAEMATOLOGICA (2018)

添加到收藏夹

Article Anatomy & Morphology

3D analysis of sexual dimorphism in size, shape and breathing kinematics of human lungs

Nicole Torres-Tamayo et al.

JOURNAL OF ANATOMY (2018)

添加到收藏夹

Article Hematology

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Travis Nemkov et al.

HAEMATOLOGICA (2018)

添加到收藏夹

Review Cell Biology

Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

Pernille Hojman et al.

CELL METABOLISM (2018)

添加到收藏夹

Article Physiology

Sex differences in large conducting airway anatomy

Paolo B. Dominelli et al.

JOURNAL OF APPLIED PHYSIOLOGY (2018)

添加到收藏夹

Article Biochemical Research Methods

A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways

Travis Nemkov et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2017)

添加到收藏夹

Article Physiology

Sex-based differences in endurance exercise muscle metabolism: impact on exercise and nutritional strategies to optimize health and performance in women

Michaela C. Devries

EXPERIMENTAL PHYSIOLOGY (2016)

添加到收藏夹

Article Biochemical Research Methods

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia

Angelo D'Alessandro et al.

JOURNAL OF PROTEOME RESEARCH (2016)

添加到收藏夹

Article Hematology

Metabolic fate of adenine in red blood cells during storage in SAGM solution

Giuseppe Paglia et al.

TRANSFUSION (2016)

添加到收藏夹

Article Chemistry, Analytical

Volumetric Absorptive Microsampling: A Dried Sample Collection Technique for Quantitative Bioanalysis

Philip Denniff et al.

ANALYTICAL CHEMISTRY (2014)

添加到收藏夹

Review Hematology

The sex difference in haemoglobin levels in adults - Mechanisms, causes, and consequences

William G. Murphy

BLOOD REVIEWS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani et al.

NATURE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Caffeine inhibits erythrocyte membrane derangement by antioxidant activity and by blocking caspase 3 activation

Ester Tellone et al.

BIOCHIMIE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Moderate Exercise Promotes Human RBC-NOS Activity, NO Production and Deformability through Akt Kinase Pathway

Frank Suhr et al.

PLOS ONE (2012)

添加到收藏夹

Article Chemistry, Analytical

Metabolomic Analysis and Visualization Engine for LC-MS Data

Eugene Melamud et al.

ANALYTICAL CHEMISTRY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo

Faidon Magkos et al.

CLINICAL LIPIDOLOGY (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.