☆ 4.5 Article

Axonal Protection by Oral Nicotinamide Riboside Treatment with Upregulated AMPK Phosphorylation in a Rat Glaucomatous Degeneration Model

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Neurosciences

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

James R. Tribble et al.

Summary: Glaucoma, the leading cause of irreversible blindness, lacks effective treatments targeting the neurodegenerative component. Utilizing RNA sequencing data and antibody labeling in human eyes, the study identified that retinal ganglion cells express the NAD salvage pathway, particularly the enzyme NMNAT2, which declines in glaucoma. This suggests that retinal ganglion cells can utilize nicotinamide and offers potential for clinical trials in glaucoma.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nicotinamide riboside activates SIRT5 deacetylation

Alyson M. Curry et al.

Summary: Human sirtuins, including SIRT5, play important roles in various cellular events and have been linked to longevity and age-related diseases. We identified a SIRT5-selective allosteric activator, nicotinamide riboside (NR), which can increase SIRT5 catalytic efficiency. The mechanism of action was explored and the NR binding site was mapped out. This discovery provides valuable insights into cellular regulations and biological functions of SIRT5 and paves the way for the development of therapeutics for metabolic disorders and age-related diseases.

FEBS JOURNAL (2023)

添加到收藏夹

Review Plant Sciences

Therapeutic application of natural products: NAD+ metabolism as potential target

Chen Guo et al.

Summary: This research provides a summary of the latest findings on the prevention and treatment of various diseases through the regulation of NAD(+) metabolism by natural products. The natural products mainly include phenols, flavonoids, glycosides, quinones, terpenoids, pyrazines, alkaloids, and phenylpropanoids, which have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic, and anti-aging effects.

PHYTOMEDICINE (2023)

添加到收藏夹

Article Cell Biology

Long-term NAD plus supplementation prevents the progression of age-related hearing loss in mice

Mustafa N. Okur et al.

Summary: Nicotinamide Riboside (NR), a NAD+ precursor, prevents the progression of age-related hearing loss (ARHL) by restoring NAD+ levels, upregulating synaptic transmission and PPAR signaling pathways, and targeting a novel lipid droplet pathway in the cochlea.

AGING CELL (2023)

添加到收藏夹

Article Ophthalmology

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial

Carlos Gustavo De Moraes et al.

Summary: A combination of nicotinamide and pyruvate showed significant short-term improvement in visual function, supporting the potential neuroprotective role of these agents in individuals with glaucoma. Long-term studies are needed to establish their usefulness in slowing disease progression.

JAMA OPHTHALMOLOGY (2022)

添加到收藏夹

Article Toxicology

Tri-ortho-cresyl phosphate induces axonal degeneration in chicken DRG neurons by the NAD plus pathway

Yan-Yan Sun et al.

Summary: Wallerian degeneration is a well-known process of clearing degenerating axons and myelin after nerve injury. Organophosphate-induced delayed neuropathy (OPIDN) is characterized by a similar degeneration of axons, but the underlying mechanism is unclear. In this study, the researchers used an in vitro model of embryonic chicken dorsal root ganglia (DRG) neurons to investigate the mechanism of axon degeneration induced by the OPIDN inducer tri-ortho-cresyl phosphate (TOCP). They found that TOCP exposure caused serious degeneration and fragmentation of the axons, as well as a collapse of mitochondrial membrane potential and depletion of ATP levels in the DRG neurons. They also observed a decrease in the expression of nicotinamide nucleotide adenylyl transferase 2 (NMNAT2) and nicotinamide adenine dinucleotide (NAD+) levels in TOCP-exposed DRG neurons. However, the TOCP-induced axon degeneration could be inhibited by ATP supplementation, and exogenous NAD+ or nicotinamide riboside could rescue the ATP deficiency and prevent axon degeneration. These findings provide insights into the pathophysiological mechanism of TOCP-induced axonal damage and suggest the potential application of NAD+ in treating OPIDN.

TOXICOLOGY LETTERS (2022)

添加到收藏夹

Article Cell Biology

Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy

Yang Deng et al.

Summary: In this study, it was found that exosomes derived from oxygen-glucose-deprivation/reoxygenation-stimulated astrocytes (OGD/R-ADEXs) reduced neuronal death and promoted autophagy by targeting AMPK/mTOR signaling. The enzyme Nampt released by OGD/R-ADEXs played a vital role in regulating autophagy and ameliorating acute ischemic stroke.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

AMPK phosphorylates NAMPT to regulate NAD+ homeostasis under ionizing radiation

Xiaoyu Liao et al.

Summary: This study reveals that under ionizing radiation, NAMPT is activated and rapidly phosphorylated, thereby enhancing its enzymatic activity and facilitating DNA repair and cell survival. These findings provide a new post-translational modification-based signaling route for cells to rapidly orchestrate NAD(+) metabolism to support DNA repair, and highlight the importance of NAMPT as a potential target for preventing ionizing radiation-induced injuries.

OPEN BIOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Neuropharmacological efficacy of metformin for stroke in rodents: A meta-analysis of preclinical trials

Wenqiao Fu et al.

Summary: This meta-analysis suggests that metformin treatment improves stroke outcomes, including neurological score, brain water content, infarct size, rotarod test, TUNEL, neuron quantity, microglia quantity, and p-AMPK levels. Despite the limitations of animal studies, this provides important reference for future high-quality preclinical trials and clinical use.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Ophthalmology

Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

Yasushi Kitaoka et al.

Summary: This study investigated the effect of netarsudil on TNF-induced axon loss and found that it increased autophagy and protected against axon degeneration.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Nicotinamide Riboside Enhances Endothelial Precursor Cell Function to Promote Refractory Wound Healing Through Mediating the Sirt1/AMPK Pathway

Zhen-hua Wang et al.

Summary: Oral uptake of nicotinamide riboside enhances EPC function to promote diabetic wound healing, indicating a promising strategy to prevent the progression of diabetic complications.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention

Stefania Vernazza et al.

Summary: Glaucoma is a neurodegenerative disease that causes damage to retinal ganglion cells and results in permanent vision loss. While Intra Ocular Pressure (IOP) is the main therapeutic target, other pathological conditions and neuroprotective therapeutic approaches also play important roles in the disease progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

James R. Tribble et al.

Summary: Research has shown that nicotinamide has neuroprotective effects on neurons affected in glaucoma, preventing metabolic disruption and increasing oxidative phosphorylation in cells to reduce firing frequency of neurons.

REDOX BIOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage

Xian Zhang et al.

Summary: This study demonstrates the protective effects of nicotinamide riboside (NR) in acute and chronic models of retinal ganglion cell (RGC) damage. The significant protection offered by NR, along with its high bioavailability and good tolerability in humans, may support the proposal of future human subject studies.

PHARMACEUTICS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator

Hirohiko Kawashima et al.

FASEB JOURNAL (2020)

添加到收藏夹

Article Cell & Tissue Engineering

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Mohammadhossein Khorraminejad-Shirazi et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Article Ophthalmology

Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

Flora Hui et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2020)

添加到收藏夹

Article Neurosciences

Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

Yasushi Kitaoka et al.

MOLECULAR NEUROBIOLOGY (2020)

添加到收藏夹

Article Ophthalmology

Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration

Xian Zhang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

添加到收藏夹

Article Ophthalmology

Neuronal apoptosis, axon damage and synapse loss occur synchronously in acute ocular hypertension

Lan Zhou et al.

EXPERIMENTAL EYE RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Autophagy activation promotes clearance of ?-synuclein inclusions in fibril-seeded human neural cells

Jianqun Gao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Ophthalmology

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

Judith Kouassi Nzoughet et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

添加到收藏夹

Review Cell Biology

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Luis Rajman et al.

CELL METABOLISM (2018)

添加到收藏夹

Article Ophthalmology

Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice*

M. C. Sanchez-Migallon et al.

EXPERIMENTAL EYE RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

Pauline Vaur et al.

FASEB JOURNAL (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Pete A. Williams et al.

SCIENCE (2017)

添加到收藏夹

Article Cell Biology

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+ elevation

Xiaojuan Han et al.

AGING CELL (2016)

添加到收藏夹

Article Multidisciplinary Sciences

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Joanna Ratajczak et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A. J. Trammell et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Ophthalmology

Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma in Persons With Diabetes Mellitus

Hsien-Chang Lin et al.

JAMA OPHTHALMOLOGY (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

Teng Jiang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

添加到收藏夹

Article Cell Biology

Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

Y. Kitaoka et al.

CELL DEATH & DISEASE (2013)

添加到收藏夹

Article Clinical Neurology

Axonal and Cell Body Protection By Nicotinamide Adenine Dinucleotide in Tumor Necrosis Factor-Induced Optic Neuropathy

Yasushi Kitaoka et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

添加到收藏夹

Article Cell Biology

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

Gareth R. Howell et al.

JOURNAL OF CELL BIOLOGY (2007)

添加到收藏夹

Article Neurosciences

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

Yo Sasaki et al.

JOURNAL OF NEUROSCIENCE (2006)

添加到收藏夹

Article Cell Biology

Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice

TC Jakobs et al.

JOURNAL OF CELL BIOLOGY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.