期刊
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
卷 30, 期 9, 页码 980-987出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GME.0000000000002220
关键词
Gynecology; Laser; Menopause; Sexual health; Urology
CO2 laser therapy may improve the overall treatment of genitourinary syndrome of menopause with a relatively good safety profile. However, further randomized clinical trials with larger sample sizes are still needed to confirm the results of this study.
CO2 laser therapy may improve the overall treatment of genitourinary syndrome of menopause with a relatively good safety profile. ImportanceData on whether the carbon dioxide (CO2) laser is useful for treatment of genitourinary syndrome of menopause (GSM) are inconsistent.ObjectiveThis meta-analysis evaluated the benefits and safety of CO2 laser compared with sham treatment of GSM.Evidence ReviewA relevant literature search of Europe PMC, MEDLINE, Scopus, and ClinicalTrials.gov databases using specific keywords was conducted. The results of continuous variables were pooled into the standardized mean difference (SMD), whereas dichotomous variables were pooled into odds ratio with 95% confidence intervals (95% CI) using random-effects models. A funnel plot was used to assess for the presence of publication bias.FindingsA total of six randomized clinical trials were included. Pooled analysis revealed that CO2 laser therapy was associated with a higher reduction in the Vaginal Assessment Scale (SMD, -0.81 [95% CI, -1.59 to -0.04]; P = 0.04; I2 = 88%) and Urinary Distress Inventory short form (SMD, -0.45 [95% CI, -0.84 to -0.06]; P = 0.02; I2 = 0%), and greater patient satisfaction rate (odds ratio, 5.46 [95% CI, 2.23 to 13.37]; P = 0.0002; I2 = 0%) when compared with sham-only treatment. Meanwhile, the Female Sexual Function Index, Vaginal Health Index, and Patient Global Impression Improvement did not differ significantly between groups. Adverse events were only mild with no serious adverse events reported.Conclusions and RelevanceCO2 laser therapy may improve the overall treatment of GSM with a relatively good safety profile. However, further randomized clinical trials with larger sample sizes are still needed to confirm the results of this study.
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