3.8 Article

Investigating the effects of a FAAH inhibitor in the laterodorsal tegmental nucleus using a new ex vivo mouse preparation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

The sex-specific metabolic signature of C57BL/6NRj mice during aging

Doruntina Bresilla et al.

Summary: C57BL/6NRj mice are an ideal model for studying cellular alterations in metabolism, and age-related metabolic alterations occur at an early stage and may be associated with a metabolic switch. There are sex-specific differences in the metabolite signatures of different tissues, and metabolomic features are highly dependent on the genetic background of mouse strains.

SCIENTIFIC REPORTS (2022)

Article Neurosciences

The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

Mark E. Schmidt et al.

Summary: JNJ-42165279 appears to have an anxiolytic effect in subjects with social anxiety disorder (SAD), although trough concentrations with 25 mg once daily seemed insufficient to completely inhibit FAAH activity, resulting in suboptimal efficacy.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

A metabolome atlas of the aging mouse brain

Jun Ding et al.

Summary: By studying the metabolome atlas of aging wildtype mouse brains, it was found that metabolites significantly differ between different brain regions or age groups, with no effect of sex on these differences. Metabolic pathways undergo changes during aging, and functionally related brain regions also show similarities in metabolism. As age increases, metabolic correlations decrease, and cross-region correlation patterns reflect decreased brain segregation.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents

Daniel Vallof et al.

ADDICTION BIOLOGY (2020)

Article Multidisciplinary Sciences

The endocannabinoid hydrolase FAAH is an allosteric enzyme

Enrico Dainese et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

Daniel Dautan et al.

NATURE COMMUNICATIONS (2020)

Review Neurosciences

Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction

Claudia Sagheddu et al.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

Alice L. Chen et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

Barbara Coimbra et al.

NATURE COMMUNICATIONS (2019)

Review Oncology

Significance of long chain polyunsaturated fatty acids in human health

Rafael Zarate et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2017)

Article Clinical Neurology

Structural and functional considerations of the cholinergic brainstem

Juan Mena-Segovia

JOURNAL OF NEURAL TRANSMISSION (2016)

Review Cell Biology

Metabolomics: beyond biomarkers and towards mechanisms

Caroline H. Johnson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Cell Biology

Age-related changes in the endocannabinoid system in the mouse hippocampus

Anastasia Piyanoya et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2015)

Article Chemistry, Analytical

Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling

H. Paul Benton et al.

ANALYTICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Endocannabinoids, Related Compounds and Their Metabolic Routes

Filomena Fezza et al.

MOLECULES (2014)

Letter Biotechnology & Applied Microbiology

Metabolomic data streaming for biology-dependent data acquisition

Duane Rinehart et al.

NATURE BIOTECHNOLOGY (2014)

Article Chemistry, Analytical

XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

Ralf Tautenhahn et al.

ANALYTICAL CHEMISTRY (2012)

Article Immunology

Serum response factor modulates neuron survival during peripheral axon injury

Sina Stern et al.

JOURNAL OF NEUROINFLAMMATION (2012)

Letter Biotechnology & Applied Microbiology

An accelerated workflow for untargeted metabolomics using the METLIN database

Ralf Tautenhahn et al.

NATURE BIOTECHNOLOGY (2012)

Letter Biotechnology & Applied Microbiology

A cross-platform toolkit for mass spectrometry and proteomics

Matthew C. Chambers et al.

NATURE BIOTECHNOLOGY (2012)

Review Neurosciences

Supply and demand for endocannabinoids

Bradley E. Alger et al.

TRENDS IN NEUROSCIENCES (2011)

Review Pharmacology & Pharmacy

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

Kay Ahn et al.

EXPERT OPINION ON DRUG DISCOVERY (2009)

Review Neurosciences

A neuroscientist's guide to lipidomics

Daniele Piomelli et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Multidisciplinary Sciences

The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

DJ Lodge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area

N Omelchenko et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2005)

Review Pharmacology & Pharmacy

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

AC Howlett et al.

PHARMACOLOGICAL REVIEWS (2002)