期刊
POLYMERS
卷 15, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/polym15143027
关键词
polyhydroxybutyrate; Azospirillum brasilense; PHB genes; PHB regulation; PHB metabolism
In this review, the PHB production by A. brasilense is analyzed, including the carbon and nitrogen sources used, the synthesis and metabolic pathways of PHB, the role of genes involved in PHB metabolism, and the applications of PHB in the physiology of Azospirillum and biomedical and commercial areas.
Gram-negative Azospirillum brasilense accumulates approximately 80% of polyhydroxybutyrate (PHB) as dry cell weight. For this reason, this bacterium has been characterized as one of the main microorganisms that produce PHB. PHB is synthesized inside bacteria by the polymerization of 3-hydroxybutyrate monomers. In this review, we are focusing on the analysis of the PHB production by A. brasilense in order to understand the metabolism during PHB accumulation. First, the carbon and nitrogen sources used to improve PHB accumulation are discussed. A. brasilense accumulates more PHB when it is grown on a minimal medium containing a high C/N ratio, mainly from malate and ammonia chloride, respectively. The metabolic pathways to accumulate and mobilize PHB in A. brasilense are mentioned and compared with those of other microorganisms. Next, we summarize the available information to understand the role of the genes involved in the regulation of PHB metabolism as well as the role of PHB in the physiology of Azospirillum. Finally, we made a comparison between the properties of PHB and polypropylene, and we discussed some applications of PHB in biomedical and commercial areas.
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