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Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis

CELLULAR & MOLECULAR BIOLOGY LETTERS (2023)

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Article Orthopedics

Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis: A meta-analysis

Sathish Muthu et al.

Summary: This study analyzed and compared the efficacy and safety of bone-marrow-derived mesenchymal stromal cells (BM-MSCs) and adipose tissue-derived MSCs (AD-MSCs) in knee osteoarthritis management. The results showed that AD-MSCs were superior to BM-MSCs in improving pain and functional outcomes, and had better safety. Further trials are needed to validate these findings and reach a consensus on the ideal source of MSCs for managing knee osteoarthritis.

WORLD JOURNAL OF ORTHOPEDICS (2023)

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Editorial Material Orthopedics

Osteoarthritis, an old wine in a new bottle!

Sathish Muthu

Summary: Osteoarthritis (OA) is a common joint disease that greatly affects patients' quality of life and healthcare services, but there is still no effective strategy for prevention or control. Previous pharmaceutical development has not provided a disease-modifying solution for OA. This editorial article discusses the challenges faced in OA research and the exciting opportunities for future management, such as personalized approaches, early disease detection with biomarkers, and improved clinical research design. Utilizing technologies like artificial intelligence and genomic profiling, the future of OA management shows promising prospects.

WORLD JOURNAL OF ORTHOPEDICS (2023)

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Article Cell & Tissue Engineering

Registered clinical trials investigating treatment with cell-derived extracellular vesicles: a scoping review

An Duong et al.

Summary: This scoping review identifies the increasing interest in cell-based therapy using extracellular vesicles (EVs) and highlights the need for standardized product characterization, quantifiable product quality attributes, and consistent outcome reporting in clinical trials to facilitate the clinical translation of EV-based treatment.

CYTOTHERAPY (2023)

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Article Biochemistry & Molecular Biology

Dental Pulp Stem Cell-Derived Exosomes Alleviate Mice Knee Osteoarthritis by Inhibiting TRPV4-Mediated Osteoclast Activation

Yu Fu et al.

Summary: Osteoarthritis (OA) is a degenerative disease that causes chronic pain and joint swelling in millions of patients. Current non-surgical treatment for OA can only relieve pain, and the efficacy of mesenchymal stem cell (MSC)-secreted exosomes therapy is uncertain. In this study, dental pulp stem cell (DPSC)-derived exosomes were shown to effectively improve subchondral bone remodeling, inhibit bone sclerosis and osteophyte formation, and alleviate cartilage degradation and synovial inflammation in a mouse knee OA model. Furthermore, DPSC-derived exosomes repressed osteoclast activation by inhibiting TRPV4 activation. These findings suggest that a single injection of DPSC-derived exosomes may be a potential strategy for knee OA treatment and TRPV4 inhibition could be a promising target for clinical OA treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Chemistry, Multidisciplinary

Osteoclast-targeted delivery of anti-miRNA oligonucleotides by red blood cell extracellular vesicles

Limei Xu et al.

Summary: This study demonstrates the use of red blood cell extracellular vesicles (RBCEVs) as a vehicle for targeted delivery of anti-miR-214 to osteoclasts. The bifunctional fusion peptide TBP-CP05 guides RBCEVs to osteoclasts both in vitro and in vivo, leading to significant inhibition of osteoclast activity and improved bone density in osteoporotic mice. This targeted delivery method may provide a potential therapy for osteoporosis.

JOURNAL OF CONTROLLED RELEASE (2023)

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Review Biotechnology & Applied Microbiology

Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Yujie Liang et al.

Summary: Developing strategies for safe and effective drug delivery into the CNS is crucial. Cell-derived nanovesicles (CDNs), particularly extracellular vesicles and exosomes, show promise as CNS-targeted drug carriers due to their stability, biocompatibility, homing ability, and ability to penetrate biological barriers. In this review, we focus on the application of CDNs in brain-targeted drug delivery, including recent methods of exosome derivation and engineering. We discuss the limitations and future development of CDN-based brain-targeted delivery systems, highlighting their potential in treating neurological diseases.

MOLECULAR THERAPY (2023)

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Stem Cell Therapy in Inflammatory Bowel Disease: A Review of Achievements and Challenges

Cheng-Mei Tian et al.

Journal of Inflammation Research (2023)

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Review Engineering, Biomedical

Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineering

Xiao Xu et al.

Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.

ACTA BIOMATERIALIA (2023)

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Article Engineering, Biomedical

Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform

Xiao Xu et al.

Summary: Exosomes, as a cell-free therapeutic approach, hold great promise. However, before clinical use, challenges in large-scale production, quality control, and heterogeneity need to be addressed. Biomimetic exosomes, called exosome-mimetics (EMs), have been created through various methods, such as extrusion, artificial synthesis, and liposome fusion, to overcome these limitations. EMs possess similar morphology and function to natural exosomes, but offer higher yields, faster large-scale production, and similar size. This article provides an overview of the chemical and biological properties of synthetic exosome systems, highlighting recent advances in production and applications, and discussing advantages, limitations, and potential clinical applications of EMs.

MATERIALS TODAY BIO (2023)

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Editorial Material Cell Biology

Clinical translation of mesenchymal stromal cell extracellular vesicles: Considerations on scientific rationale and production requisites

Yvan Courageux et al.

Summary: The paper discusses the impact of isolation methods on the preparation of mesenchymal stromal cell-derived extracellular vesicles, emphasizing the importance of ensuring high consistency in safety, composition, and biological activity evidence, as well as the suitability of different isolation techniques.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Review Orthopedics

Osteoarthritis year in review 2021: epidemiology & therapy

J. G. Quicke et al.

Summary: This article reviews research themes and individual studies in the clinical osteoarthritis field, including COVID-19, disease burden, occupational risk, prediction models, etc. Important findings include the impact of non-steroidal anti-inflammatory drugs on COVID-19 related deaths, the increasing incidence rate of OA, and the relationship between cartilage thickness loss and pain.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Chemistry, Multidisciplinary

Three-Dimensional-Cultured MSC-Derived Exosome-Hydrogel Hybrid Microneedle Array Patch for Spinal Cord Repair

Min Han et al.

Summary: Exosomes derived from three-dimensional culture of MSCs have shown great potential in spinal cord injury therapy, compared to exosomes from conventional two-dimensional culture. It is urgent to develop a reliable, convenient, and effective exosome delivery method for constant in situ release.

NANO LETTERS (2022)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage

Hao Zhou et al.

Summary: This study demonstrated that hucMSCs-EVs slowed the progression of OA by reducing inflammation, increasing key protein expression, and promoting chondrocyte proliferation, migration, and inhibiting apoptosis. The mechanism involved the regulation of inflammation factors through targeting specific molecules, providing a novel therapeutic approach for clinical OA treatment.

STEM CELL RESEARCH & THERAPY (2022)

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Review Biochemistry & Molecular Biology

The role of macrophage subtypes and exosomes in immunomodulation

Abdulwahab Teflischi Gharavi et al.

Summary: This article provides an overview of macrophage polarization, their different subtypes, and their importance in immune responses and pathological conditions. Additionally, the review explores the role and potential of exosomes in M1/M2-like macrophage polarization.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Biochemistry & Molecular Biology

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Mahmoud Al-Azab et al.

Summary: Human mesenchymal stem cells (MSCs) play important roles in tissue homeostasis, aging-related diseases, and cellular therapy. Understanding the mechanisms and signs of MSC cellular senescence is crucial for combating aging and cellular senescence. This review discusses the factors contributing to MSC senescence and strategies to reverse it.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Oncology

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Madhan Jeyaraman et al.

Summary: This article reviews the current understanding of the role of MSC-Exos in the management of knee osteoarthritis, including their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro and in-vivo evidence, and recent advances in research.

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Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Yujie Liang et al.

Summary: This study developed a specific delivery vehicle for gene editing in chondrocytes to attenuate cartilage damage. The results showed that the hybrid delivery vehicle successfully delivered the gene plasmids and suppressed the expression of specific genes in chondrocytes, leading to a decrease in cartilage degradation. This research contributes to alleviating the symptoms and damage of osteoarthritis.

THERANOSTICS (2022)

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Review Materials Science, Biomaterials

Cell-derived extracellular vesicles for CRISPR/Cas9 delivery: engineering strategies for cargo packaging and loading

Yujie Liang et al.

Summary: Genome editing technology has the potential to treat incurable diseases, but the development of delivery systems is lagging behind. Extracellular vesicles (EVs), as natural nanocarriers, have advantages of biocompatibility and stability, making them a promising drug delivery vehicle.

BIOMATERIALS SCIENCE (2022)

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Review Oncology

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Madhan Jeyaraman et al.

Summary: This article reviews the current understanding of the role of mesenchymal stem cell-derived exosomes in the management of knee osteoarthritis, covering their classification, characterization, biogenesis, mechanism of action, pathways involved in therapeutic action, in vitro evidence on cartilage regeneration, in vivo evidence in OA knee models, and recent advances in using MSC-Exos.

EXPERIMENTAL CELL RESEARCH (2022)

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Article Orthopedics

Implications of Anti-Inflammatory Nature of Exosomes in Knee Arthritis

William Fang et al.

Summary: Exosomes are important extracellular vesicles that mediate intercellular communication and play crucial roles in various biological processes. Exosomes released from mesenchymal stem cells have potential therapeutic value for inflammation in joint diseases. Research has shown that exosomes can be used as biomarkers for tracking the pathogenesis and prognosis of inflammatory arthritis.

CARTILAGE (2021)

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Article Orthopedics

Mesenchymal Stem Cell-Derived Exosomes: A Potential Therapeutic Avenue in Knee Osteoarthritis

Madhan Jeyaraman et al.

Summary: Researchers are continually developing new technologies for the treatment of knee osteoarthritis, including cell-based therapies and exosomal therapy. These new technologies can improve the quality of cartilage and alleviate symptomatic pain, potentially becoming the future direction for the management of knee osteoarthritis.

CARTILAGE (2021)

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Article Cell Biology

TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6

Rui Wang et al.

Summary: Our study demonstrated that BMSCs-Exo(TGF-beta 1) alleviated cartilage damage in OA rats by carrying highly expressed miR-135b, and revealed the mechanism of miR-135b in promoting M2 polarization of SMs.

CELL AND TISSUE RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis

Li Duan et al.

Summary: Osteoarthritis is a degenerative disease that affects the quality of life in the elderly population, with no ideal treatment strategies currently available. Studies have suggested that exosomes may play an important role in the treatment of osteoarthritis.

CURRENT MEDICINAL CHEMISTRY (2021)

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Review Oncology

Challenges and advances in clinical applications of mesenchymal stromal cells

Tian Zhou et al.

Summary: MSC therapy for clinical applications faces challenges due to inconsistent criteria for MSCs identity and their inherited heterogeneity. Strategies have been developed to overcome these challenges with the emergence of advanced biological techniques and substantial improvements in bio-engineered materials.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Cell Biology

A brief history of nearly EV-erything - The rise and rise of extracellular vesicles

Yvonne Couch et al.

Summary: Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space, serving as a complex cell-to-cell communication mechanism that transfers functional cargo and influences biological processes, with deregulation in disease. The field of EVs has grown exponentially over the past two decades with an organized community, but still faces key challenges.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Biochemistry & Molecular Biology

Exosomes as Targeted Delivery Platform of CRISPR/Cas9 for Therapeutic Genome Editing

Li Duan et al.

Summary: This review discusses the recent progress of using exosomes as delivery vehicles for the CRISPR/Cas system to achieve therapeutic gene editing for disease treatment. Various strategies for achieving selective delivery to a particular type of cell and efficient packaging of the genome editing tools in the vesicles are highlighted. Critical issues and possible solutions in the design and engineering of the targeting vehicles are emphasized.

CHEMBIOCHEM (2021)

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Article Immunology

Low-intensity pulsed ultrasound promotes osteoarthritic cartilage regeneration by BMSC-derived exosomes via modulating the NF-ΚB signaling pathway

Qing Liao et al.

Summary: Studies have shown that LIPUS-mediated BMSC-derived exosomes can promote cartilage regeneration, increase chondrocyte proliferation and extracellular matrix synthesis, and suppress inflammation. The underlying mechanism may involve the inhibition of IL-1 beta-induced activation of the NF-Kappa B pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Cell Biology

Therapeutic effects of bone marrow mesenchymal stem cells-derived exosomes on osteoarthritis

Yi Jin et al.

Summary: The study revealed that exosomes derived from BM-MSCs could alleviate cartilage destruction and subchondral bone remodeling in OA rat models, while also restoring bone density and connectivity. Furthermore, these exosomes maintained chondrocyte phenotype, reducing cellular senescence and apoptosis as potential therapeutic targets for OA treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Oncology

The MYC oncogene - the grand orchestrator of cancer growth and immune evasion

Renumathy Dhanasekaran et al.

Summary: The MYC proto-oncogenes are among the most commonly activated proteins in human cancer, with their activation affecting cancer cell pathophysiology, disrupting the tumor microenvironment, and suppressing host immune responses. Therapies targeting the MYC pathway may play a key role in reversing cancerous growth and restoring antitumor immune responses.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Rheumatology

Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis

Zhenye Guo et al.

Summary: The study reveals that circ-BRWD1 plays a crucial role in osteoarthritis, promoting IL-1 beta-induced damage of CHON-001 cells by regulating the miR-1277/TRAF6 axis. Silencing circ-BRWD1 enhances cell viability and proliferation, while reducing apoptosis, inflammation, and extracellular matrix degradation.

ARTHRITIS RESEARCH & THERAPY (2021)

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Review Chemistry, Multidisciplinary

Cell-free exosome-laden scaffolds for tissue repair

Jianghong Huang et al.

Summary: With the advancement of regenerative medicine, exosomes, as nanoscale extracellular vesicles transporting biologically active molecules, play a vital role in tissue repair. Exosomes can replicate the functions of parent cells and serve as nanocarriers to deliver active factors promoting tissue repair.

NANOSCALE (2021)

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Exosome-mediated delivery of gene vectors for gene therapy

Li Duan et al.

Summary: Gene vectors deliver genetic materials or gene editing devices into cells for therapeutic protein production or gene correction, but barriers like cell membrane and degradation necessitate carriers for clinical gene therapy. Exosomes, engineered to encapsulate and deliver nucleic acids, and their fusion with liposomes increase loading capacity and maintain targeting capability, showing promise for future gene delivery applications in therapy.

NANOSCALE (2021)

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Review Medicine, Research & Experimental

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Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis

Manuela Zavatti et al.

BIOFACTORS (2020)

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Review Engineering, Biomedical

The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents

Quan-fa Zhou et al.

ACTA BIOMATERIALIA (2020)

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Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair

Chun Liu et al.

NANOMEDICINE (2020)

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DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses

Kazuhiro Hitomi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury

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STEM CELL RESEARCH & THERAPY (2020)

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Review Orthopedics

Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature

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ORTHOPAEDIC SURGERY (2020)

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Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis

Jose Maria Lamo-Espinosa et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

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JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Current understanding of the immunosuppressive properties of mesenchymal stromal cells

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The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease

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Article Cell & Tissue Engineering

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Jose Matas et al.

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Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration

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MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

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Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM)

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hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation

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Exosomes: Therapy delivery tools and biomarkers of diseases

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PHARMACOLOGY & THERAPEUTICS (2017)

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Review Cell Biology

MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

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Article Cell & Tissue Engineering

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1-Primed Mesenchymal Stem Cells Against Sepsis

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STEM CELLS (2017)

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Article Multidisciplinary Sciences

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

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NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Akiko Takahashi et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

Stella Cosenza et al.

SCIENTIFIC REPORTS (2017)

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Article Cell & Tissue Engineering

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

Yafei Wang et al.

STEM CELL RESEARCH & THERAPY (2017)

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Article Medicine, Research & Experimental

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Shi-Cong Tao et al.

THERANOSTICS (2017)

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Review Cell & Tissue Engineering

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

Di Chen et al.

BONE RESEARCH (2017)

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Review Oncology

Cell therapy for the treatment of sepsis and acute respiratory distress syndrome

Raquel Guillamat-Prats et al.

ANNALS OF TRANSLATIONAL MEDICINE (2017)

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Article Cell Biology

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper

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JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Pathology

Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells

Donatella Lucchetti et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

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Article Cell & Tissue Engineering

RECENT ADVANCES IN HYDROGELS FOR CARTILAGE TISSUE ENGINEERING

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EUROPEAN CELLS & MATERIALS (2017)

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Review Rheumatology

Synovitis in osteoarthritis: current understanding with therapeutic implications

Alexander Mathiessen et al.

ARTHRITIS RESEARCH & THERAPY (2017)

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Article Cell Biology

Sp1 upregulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes

Keijirou Watanabe et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2016)

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Article Pharmacology & Pharmacy

lncRNA/MicroRNA Interactions in the Vasculature

M. D. Ballantyne et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)

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Article Immunology

Immunomodulatory effects of mesenchymal stromal cells-derived exosome

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IMMUNOLOGIC RESEARCH (2016)

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Article Medicine, Research & Experimental

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

Jose M. Lamo-Espinosa et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

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Article Orthopedics

Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment, of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration

Robert Soler et al.

KNEE (2016)

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Article Orthopedics

MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses

F. Meng et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

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Article Multidisciplinary Sciences

Chondrogenic Potential of Peripheral Blood Derived Mesenchymal Stem Cells Seeded on Demineralized Cancellous Bone Scaffolds

Shao-Jie Wang et al.

SCIENTIFIC REPORTS (2016)

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Article Orthopedics

The epidemiology of failure in total knee arthroplasty

M. Khan et al.

Bone & Joint Journal (2016)

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Article Multidisciplinary Sciences

Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering

Tangni Gomez-Leduc et al.

SCIENTIFIC REPORTS (2016)

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Article Rheumatology

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

Yujie Liang et al.

ARTHRITIS RESEARCH & THERAPY (2016)

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Review Biochemistry & Molecular Biology

ESCRTs are everywhere

James H. Hurley

EMBO JOURNAL (2015)

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Review Materials Science, Biomaterials

Cartilage Repair Using Hydrogels: A Critical Review of in Vivo Experimental Designs

C. A. Vilela et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Materials Science, Biomaterials

Cartilage Repair Using Hydrogels: A Critical Review of in Vivo Experimental Designs

C. A. Vilela et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

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Review Medicine, Research & Experimental

Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review)

Carlo Maria Di Liegro et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)

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Article Cell & Tissue Engineering

microRNA-140 Targets RALA and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of SOX9 and ACAN

Tommy A. Karlsen et al.

STEM CELLS AND DEVELOPMENT (2014)

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Article Cell Biology

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

Danijela Koppers-Lalic et al.

CELL REPORTS (2014)

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Article Engineering, Biomedical

Regulation of the osteoblastic and chondrocytic differentiation of stem cells by the extracellular matrix and subsequent bone formation modes

Jing He et al.

BIOMATERIALS (2013)

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Article Cell Biology

MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage Formation

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DEVELOPMENTAL CELL (2013)

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Review Biochemistry & Molecular Biology

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

Ashish R. Sharma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Review Biochemistry & Molecular Biology

mRNA on the Move: The Road to Its Biological Destiny

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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

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Article Orthopedics

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7

M. M. J. Caron et al.

OSTEOARTHRITIS AND CARTILAGE (2013)

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Article Rheumatology

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes

Tetsuya Matsukawa et al.

ARTHRITIS RESEARCH & THERAPY (2013)

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Article Multidisciplinary Sciences

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

Carolina Villarroya-Beltri et al.

NATURE COMMUNICATIONS (2013)

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Review Rheumatology

Osteoarthritis: A disease of the joint as an organ

Richard F. Loeser et al.

ARTHRITIS AND RHEUMATISM (2012)

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Article Engineering, Biomedical

The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling

Onju Ham et al.

BIOMATERIALS (2012)

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Review Biochemistry & Molecular Biology

MicroRNA regulatory networks and human disease

Yin-Yuan Mo

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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Article Orthopedics

Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis

Yong-Gon Koh et al.

KNEE (2012)

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Review Orthopedics

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

B. J. E. de Lange-Brokaar et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

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Article Multidisciplinary Sciences

A Stem Cell-Based Approach to Cartilage Repair

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SCIENCE (2012)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells

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CELL TRANSPLANTATION (2011)

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Article Cell & Tissue Engineering

Lifespan of human amniotic fluid-derived multipotent mesenchymal stromal cells

Jose Maria Miranda-Sayago et al.

CYTOTHERAPY (2011)

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Review Cell Biology

The ESCRT Pathway

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DEVELOPMENTAL CELL (2011)

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Article Cell Biology

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

Guillaume van Niel et al.

DEVELOPMENTAL CELL (2011)

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Article Rheumatology

Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients

Fereydoun Davatchi et al.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2011)

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Article Medicine, Research & Experimental

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Tian Sheng Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

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Article Cell & Tissue Engineering

Hydrogels for the Repair of Articular Cartilage Defects

Kara L. Spiller et al.

TISSUE ENGINEERING PART B-REVIEWS (2011)

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Article Anatomy & Morphology

Hypertrophy in Mesenchymal Stem Cell Chondrogenesis: Effect of TGF-beta Isoforms and Chondrogenic Conditioning

Michael B. Mueller et al.

CELLS TISSUES ORGANS (2010)

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Article Biochemistry & Molecular Biology

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Cell Biology

Rab27a and Rab27b control different steps of the exosome secretion pathway

Matias Ostrowski et al.

NATURE CELL BIOLOGY (2010)

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Review Cell Biology

Membrane budding and scission by the ESCRT machinery: it's all in the neck

James H. Hurley et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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Review Orthopedics

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

S. Clockaerts et al.

OSTEOARTHRITIS AND CARTILAGE (2010)

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Review Biochemistry & Molecular Biology

MicroRNAs: Target Recognition and Regulatory Functions

David P. Bartel

CELL (2009)

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Article Cell Biology

Exosomes - vesicular carriers for intercellular communication

Mikael Simons et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

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Article Biochemistry & Molecular Biology

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

Linda Troeberg et al.

MATRIX BIOLOGY (2009)

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Article Rheumatology

Synovial fluid mesenchymal stem cells in health and early osteoarthritis - Detection and functional evaluation at the single-cell level

Elena A. Jones et al.

ARTHRITIS AND RHEUMATISM (2008)

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Article Multidisciplinary Sciences

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

Dimitrios Iliopoulos et al.

PLOS ONE (2008)

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Review Biochemistry & Molecular Biology

TGFβ1 and Treg cells:: alliance for tolerance

Ramireddy Bommireddy et al.

TRENDS IN MOLECULAR MEDICINE (2007)

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Review Pharmacology & Pharmacy

Cell death and apoptosis in ostearthritic cartilage

H. A. Kim et al.

CURRENT DRUG TARGETS (2007)

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Review Biochemistry & Molecular Biology

The control of chondrogenesis

MB Goldring et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2006)

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Article Multidisciplinary Sciences

Control of regulatory T cell development by the transcription factor Foxp3

S Hori et al.

SCIENCE (2003)

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Article Oncology

Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components

F Barry et al.

EXPERIMENTAL CELL RESEARCH (2001)

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Article Orthopedics

Induction of apoptosis in bovine articular chondrocyte by prostaglandin E-2 through cAMP-dependent pathway

M Miwa et al.

OSTEOARTHRITIS AND CARTILAGE (2000)

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