期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 65, 期 6, 页码 315-322出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2015.1119688
关键词
Gelatin; wound dressing; gas foaming; tensile strength; cytotoxicity
资金
- Armourers & Brasiers' Gauntlet Trust (UK)
- Fundacao para a Ciencia e Tecnologia (FCT) [PTDC/EQU-EQU/114231/2009]
- [SFRH/BD/61450/2009]
- [IF/00442/2012]
Gelatin's excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties. [GRAPHICS] .
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