4.5 Article

The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1

期刊

MOLECULAR AND CELLULAR BIOLOGY
卷 43, 期 10, 页码 485-499

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/10985549.2023.2255120

关键词

insulin receptor; IRES; EIF4G; translational control; internal ribosome entry site; dTAG

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IRES-mediated translation initiation requires a different set of factors compared to canonical cap-dependent translation. Cellular IRES mechanisms may resemble viral type III IRESes, allowing them to function with limited initiation factors under stress conditions.
IRES mediated translation initiation requires a different repertoire of factors than canonical cap-dependent translation. Treatments that inhibit the canonical translation factor EIF4G1 have little or no effect on the ability of the Insr and Igf1r cellular IRESes to promote translation. Transcripts for two cellular receptors contain RNA elements that facilitate translation initiation without intact EIF4G1. Cellular IRES mechanisms may resemble viral type III IRESes allowing them to promote translate with a limited number of initiation factors allowing them to work under stress conditions when canonical translation is repressed.

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