European Society of Organ Transplantation (ESOT) Consensus Report on Downstaging, Bridging and Immunotherapy in Liver Transplantation for Hepatocellular Carcinoma

Article Surgery

Liver transplantation for hepatocellular carcinoma following checkpoint inhibitor therapy with nivolumab

Gabriel T. Schnickel et al.

Summary: The use of checkpoint inhibitors (CPI) prior to liver transplantation (LT), especially within 90 days of LT, is associated with biopsy-proven acute cellular rejection (BPACR) and immune-mediated hepatic necrosis.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Effect of camrelizumab plus transarterial chemoembolization on massive hepatocellular carcinoma

Sujing Zhang et al.

Summary: The combination of camrelizumab and transarterial chemoembolization (TACE) shows promising efficacy in treating patients with massive hepatocellular carcinoma (HCC), as it improves liver function and reduces adverse events significantly.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2022)

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Article Oncology

Long-term outcomes of deceased donor liver transplantation in hepatocellular carcinoma patients with portal vein tumor thrombus: A multicenter study

Jiongjie Yu et al.

Summary: Deceased donor liver transplantation (DDLT) may be a viable treatment option for hepatocellular carcinoma (HCC) patients with type 1 or 2 portal vein tumor thrombus (PVTT). Preoperative alpha-fetoprotein (AFP) levels should be considered in selecting PVTT patients for DDLT to achieve better treatment outcomes.

EJSO (2022)

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Article Oncology

Transarterial chemoembolization combined with camrelizumab for recurrent hepatocellular carcinoma

Yusheng Guo et al.

Summary: This study evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with camrelizumab in treating recurrent hepatocellular carcinoma (R-HCC). The results showed that TACE-camrelizumab had similar efficacy to TACE-alone in terms of objective response rate, disease control rate, progression-free survival, and survival rates. Neutrophil-to-lymphocyte ratio was significantly associated with progression-free survival. Adverse events related to camrelizumab were observed in a majority of patients, but none were severe.

BMC CANCER (2022)

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Article Oncology

Living donor liver transplantation for advanced hepatocellular carcinoma including macrovascular invasion

Abu Bakar Hafeez Bhatti et al.

Summary: This study reported outcomes in HCC patients who underwent LDLT outside traditional criteria, including MVI. Results showed acceptable survival can be achieved with LDLT for HCC when considering factors such as AFP levels, response to downstaging, and degree of MVI.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

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Article Medicine, General & Internal

Clinical application of gelatin sponge microparticles-transcatheter arterial chemoembolization combined with synchronous antigen-presenting dendritic cell sequential reinfusion for treatment of advanced large liver cancer A single-center, prospective, non-randomized, controlled trial

Guang Sheng Zhao et al.

Summary: The study evaluated the clinical efficacy and safety of GSMs-TACE plus synchronous DC sequential reinfusion for large liver cancer, showing that this treatment significantly prolonged survival time, improved tumor response rate and physical score, reduced intervention frequency, and is suitable for comprehensive treatment of advanced larger LC patients in China.

MEDICINE (2022)

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Article Oncology

Expansion of Liver Transplantation Criteria for Hepatocellular Carcinoma from Milan to UCSF in Australia and New Zealand and Justification for Metroticket 2.0

Savio G. Barreto et al.

Summary: Liver transplantation (LT) is an effective treatment for hepatocellular carcinoma (HCC), and the selection of criteria for LT has evolved over time. This study analyzed data from the past 24 years in Australia and New Zealand to assess the impact of expanding criteria on patient survival. The results showed that overall survival following LT for HCC has improved over time, and patients meeting the expanded criteria have comparable survival rates to those meeting the previous criteria.

CANCERS (2022)

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Article Gastroenterology & Hepatology

Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial

Ahmed Omar Kaseb et al.

Summary: This study aimed to evaluate the safety and tolerability of perioperative immunotherapy in patients with resectable hepatocellular carcinoma. The findings suggest that nivolumab alone or in combination with ipilimumab is safe and feasible in this patient population, supporting further studies of immunotherapy in the perioperative setting for hepatocellular carcinoma.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

Thomas U. Marron et al.

Summary: This study evaluated the clinical activity of neoadjuvant cemiplimab in patients with resectable hepatocellular carcinoma. The results showed that treatment with cemiplimab resulted in significant tumor necrosis and partial response in some patients. Adverse events were common but severe adverse events were rare. These findings contribute to further understanding the clinical benefit of preoperative PD-1 blockade in patients with hepatocellular carcinoma.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

Hepatocellular carcinoma downstaging for liver transplantation in the era of systemic combined therapy with anti-VEGF/TKI and immunotherapy

Nguyen H. Tran et al.

Summary: Hepatocellular carcinoma is a global health challenge, and liver transplantation is the best long-term treatment option. Locoregional methods for downstaging have limitations, while systemic treatments show potential for downstaging before transplantation. Assessment, endpoints, and clinical trial designs are critical considerations.

HEPATOLOGY (2022)

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Article Oncology

Nivolumab after selective internal radiation therapy for the treatment of hepatocellular carcinoma: a phase 2, single-arm study

Manuel de la Torre-Alaez et al.

Summary: This study evaluated the safety and efficacy of selective internal radiation therapy (SIRT) in combination with a PD-1 inhibitor nivolumab in patients with unresectable hepatocellular carcinoma (uHCC). The results showed that the combination of SIRT and nivolumab had a positive anti-tumor activity and an acceptable safety profile.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Surgery

Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma

Parissa Tabrizian et al.

Summary: This study aimed to investigate the 10-year outcomes of patients with hepatocellular carcinoma (HCC) after liver transplant (LT), particularly those who were downstaged to meet the transplant criteria. The results showed that patients who successfully downstaged their disease had better overall survival rates, validating the effectiveness of downstaging and highlighting the importance of individualized decision-making when choosing surgical management for HCC recurrence after LT.

JAMA SURGERY (2022)

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Article Surgery

Are Current National Review Board Downstaging Protocols for Hepatocellular Carcinoma Too Restrictive?

Ola Ahmed et al.

Summary: This study assessed liver transplantation outcomes for hepatocellular carcinoma (HCC) patients initially presenting beyond the expanded University of California San Francisco (B-eUCSF) criteria. The results showed that patients initially presenting beyond B-eUCSF criteria achieved comparable survival rates to those meeting the criteria (W-eUCSF) after transplantation.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2022)

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Letter Surgery

PD-1 inhibitor as bridge therapy to liver transplantation?

Parissa Tabrizian et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Review Gastroenterology & Hepatology

Perspectives on the Neoadjuvant Use of Immunotherapy in Hepatocellular Carcinoma

David J. Pinato et al.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Rescue liver re-transplantation after graft loss due to severe rejection in the setting of pre-transplant nivolumab therapy

Yalda Dehghan et al.

Summary: The use of ICI before solid organ transplantation may lead to graft rejection, caution should be taken in such cases until further research on their safety in the pre-transplant setting is conducted.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Downstaging Outcomes for Hepatocellular Carcinoma: Results From the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium

Neil Mehta et al.

Summary: This study is the first multiregional study based on UNOS-DS criteria, showing a successful downstaging rate of >80% and similar efficacy of chemoembolization and yttrium-90 radioembolization as the initial downstaging treatment. Despite a 2-year post-LT survival rate of 95%, a high rate of tumor understaging was observed.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant

Tiffany Cho-Lam Wong et al.

Summary: The study showed that stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for HCC has a significantly higher tumor control rate and lower risk of waitlist dropout compared to conventional bridging therapies, making it a safe alternative option.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Deceased Donor Liver Transplantation After Radioembolization for Hepatocellular Carcinoma and Portal Vein Tumoral Thrombosis: A Pilot Study

Matteo Serenari et al.

Summary: This study evaluated the effect of TARE in downstaging HCC patients with PVTT to meet criteria for DDLT. 5 out of 17 patients were able to undergo DDLT after TARE and showed significantly higher 5-year overall survival compared to those who were not transplanted. Careful selection for DDLT is advised despite the clear survival gain in patients who received DDLT after TARE.

LIVER TRANSPLANTATION (2021)

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Article Immunology

Pretransplant use of toripalimab for hepatocellular carcinoma resulting in fatal acute hepatic necrosis in the immediate postoperative period

Guang-Hou Chen et al.

Summary: This study explores the safety of using immune checkpoint inhibitors before liver transplantation, finding that pretransplant use may lead to immune rejection reactions posttransplantation.

TRANSPLANT IMMUNOLOGY (2021)

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Letter Immunology

Durvalumab as a Successful Downstaging Therapy for Liver Transplantation in Hepatocellular Carcinoma: The Importance of a Washout Period

Miguel Sogbe et al.

TRANSPLANTATION (2021)

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Review Immunology

Neoadjuvant Programmed Cell Death 1 (PD-1) Inhibitor Treatment in Patients With Hepatocellular Carcinoma Before Liver Transplant: A Cohort Study and Literature Review

Zi-yun Qiao et al.

Summary: The study investigated the safety and efficacy of neoadjuvant PD-1 blockade in LT recipients with HCC, showing promising results in terms of objective response rate and disease control rate. The combination therapy of PD-1 blockade and tyrosine kinase inhibitors demonstrated effective outcomes with acceptable mortality, highlighting the potential of this approach in transplant recipients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria

Helena Degroote et al.

Summary: Successful downstaging of more advanced hepatocellular carcinoma (HCC) within the UCSF-DS protocol to the conventional Milan criteria does not result in a higher recurrence rate after liver transplantation (LT) compared to patients remaining within Milan criteria. Additionally, in the UCSF-DS group, an ALP value equal to or below 20 ng/ml at listing might be a novel tool to further optimize selection of candidates for LT.

JHEP REPORTS (2021)

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Article Oncology

Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity

Won Jin Ho et al.

Summary: A study evaluating neoadjuvant cabozantinib and nivolumab in patients with hepatocellular carcinoma (HCC) showed that 80% of patients successfully underwent hepatic resection surgery, with 42% having major pathological responses. An in-depth biospecimen profiling indicated an orchestrated contribution of B cells to antitumor immunity in HCC, with effector T cells, tertiary lymphoid structures, CD138(+) plasma cells, and a distinct spatial arrangement of B cells being enriched in responders compared to nonresponders.

NATURE CANCER (2021)

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Article Medicine, General & Internal

Comparison of Liver Transplantation and Liver Resection for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Type I and Type II

Jia-Yu Lv et al.

Summary: Liver transplantation (LT) appeared to provide better prognosis for HCC patients with PVTT type I compared to liver resection (LR), especially in patients with AFP levels >200 ng/mL. There were no significant differences in prognosis between LT and LR for patients with PVTT type II. Risk factors for recurrence-free survival (RFS) and overall survival (OS) included treatment allocation (LR), tumor size (>5 cm), AFP and aspartate aminotransferase (AST) levels.

YONSEI MEDICAL JOURNAL (2021)

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Article Surgery

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma Analysis From the US Multicenter HCC Transplant Consortium

Joseph DiNorcia et al.

ANNALS OF SURGERY (2020)

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Article Gastroenterology & Hepatology

National Experience on Down-Staging of Hepatocellular Carcinoma Before Liver Transplant: Influence of Tumor Burden, Alpha-Fetoprotein, and Wait Time

Neil Mehta et al.

HEPATOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Acetic acid versus radiofrequency ablation for the treatment of hepatocellular carcinoma: A randomized controlled trial

S. B. Paul et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2020)

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Article Surgery

Fatal hepatic necrosis after nivolumab as a bridge to liver transplant for HCC: Are checkpoint inhibitors safe for the pretransplant patient?

Mina F. Nordness et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Safety of Combined Yttrium-90 Radioembolization and Immune Checkpoint Inhibitor Immunotherapy for Hepatocellular Carcinoma

Chenyang Zhan et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

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Article Oncology

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

Richard S. Finn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Surgery

Liver transplantation for hepatocellular carcinoma after successful treatment of macrovascular invasion - a multi-center retrospective cohort study

Michela Assalino et al.

TRANSPLANT INTERNATIONAL (2020)

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Article Immunology

Experience With LDLT in Patients With Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis Postdownstaging

Arvinder S. Soin et al.

TRANSPLANTATION (2020)

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Article Gastroenterology & Hepatology

Prospective double-blinded randomized controlled trial of Microwave versus RadioFrequency Ablation for hepatocellular carcinoma (McRFA trial)

C. N. Chong Chong et al.

HPB (2020)

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Editorial Material Gastroenterology & Hepatology

Immunotherapy as a Downstaging Therapy for Liver Transplantation

Birgit Schwacha-Eipper et al.

HEPATOLOGY (2020)

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Review Oncology

Impact of successful local ablative bridging therapy prior to liver transplantation on long-term survival in patients with hepatocellular carcinoma in cirrhosis

Astrid Bauschke et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

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Article Oncology

Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial

Vincenzo Mazzaferro et al.

LANCET ONCOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Safety and Efficacy of Locoregional Treatment during Immunotherapy with Nivolumab for Hepatocellular Carcinoma: A Retrospective Study of 41 Interventions in 29 Patients

Brett Marinelli et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

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Article Oncology

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib The CheckMate 040 Randomized Clinical Trial

Thomas Yau et al.

JAMA ONCOLOGY (2020)

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Review Oncology

Microwave Ablation Versus Radiofrequency Ablation for Treatment of Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials

Antonio Facciorusso et al.

CANCERS (2020)

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Article Oncology

Safety of nivolumab in combination with prior or concurrent radiation therapy in hepatocellular carcinoma

William H. Smith et al.

JOURNAL OF RADIATION ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells

Viviane Theodoro et al.

HELIYON (2020)

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Article Gastroenterology & Hepatology

The Intention-to-Treat Effect of Bridging Treatments in the Setting of Milan Criteria-In Patients Waiting for Liver Transplantation

Quirino Lai et al.

LIVER TRANSPLANTATION (2019)

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Article Cardiac & Cardiovascular Systems

Radioablation by Image-Guided (HDR) Brachytherapy and Transarterial Chemoembolization in Hepatocellular Carcinoma: A Randomized Phase II Trial

Konrad Mohnike et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2019)

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Article Oncology

Percutaneous radiofrequency versus microwave ablation for management of hepatocellular carcinoma: a randomized controlled trial

Ahmed Kamal et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

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Review Gastroenterology & Hepatology

Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta-analysis

Laura Kulik et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Excellent Outcomes of Liver Transplantation Following Down-Staging of Hepatocellular Carcinoma to Within Milan Criteria: A Multicenter Study

Neil Mehta et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Article Surgery

Impact of remnant vital tissue after locoregional treatment and liver transplant in hepatocellular cancer patients, a multicentre cohort study

Tommaso M. Manzia et al.

TRANSPLANT INTERNATIONAL (2018)

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Article Cell Biology

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Mohammed Alnaggar et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Gastroenterology & Hepatology

Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial

Naik Vietti Violi et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

The Impact of Bridging LRT on Survival in Patients Listed for Liver Transplantation

Peiman Habibollahi et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma

Minzhi Xing et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2017)

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Letter Gastroenterology & Hepatology

Percutaneous cooled-probe microwave versus radiofrequency ablation in early-stage hepatocellular carcinoma: a phase III randomised controlled trial

Jie Yu et al.

GUT (2017)

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Article Oncology

Independent prognostic factors for posttransplant survival in hepatocellular carcinoma patients undergoing liver transplantation

Minzhi Xing et al.

CANCER MEDICINE (2017)

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Article Surgery

Multimodality locoregional treatment strategies for bridging HCC patients before liver transplantation

Georg P. Gyoeri et al.

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA (2017)

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Article Transplantation

Effect of Downstaging and Bridging of Hepatocellular Carcinoma on Survival Following Liver Transplant: A Single Center Experience

Mohammed I. Al Sebayel et al.

EXPERIMENTAL AND CLINICAL TRANSPLANTATION (2017)

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Article Immunology

Comparison of radiofrequency ablation alone & in combination with percutaneous ethanol injection for management of hepatocellular carcinoma

Naveen Kalra et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2017)

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Editorial Material Gastroenterology & Hepatology

Assessment of treatment efficacy in hepatocellular carcinoma: Response rate, delay in progression or none of them

Jordi Bruix et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients with hepatocellular carcinoma. An intention-to-treat analysis

Gonzalo Sapisochin et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Validation of the AFP model as a predictor of HCC recurrence in patients with viral hepatitis-related cirrhosis who had received a liver transplant for HCC

Andrea Notarpaolo et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma

Austin G. Duffy et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Surgery

Liver Transplantation for Advanced Hepatocellular Carcinoma after Downstaging Without Up-Front Stage Restrictions

William C. Chapman et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Effect of Bridging Local-Regional Therapy on Recurrence of Hepatocellular Carcinoma and Survival after Orthotopic Liver Transplantation

Hayley C. Oligane et al.

RADIOLOGY (2017)

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Article Oncology

Liver Transplantation is a Preferable Alternative to Palliative Therapy for Selected Patients with Advanced Hepatocellular Carcinoma

Aloysious D. Aravinthan et al.

ANNALS OF SURGICAL ONCOLOGY (2017)

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Article Gastroenterology & Hepatology

Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

Riad Salem et al.

GASTROENTEROLOGY (2016)

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Article Immunology

TACE combined with dendritic cells and cytokine-induced killer cells in the treatment of hepatocellular carcinoma: A meta-analysis

Guangzhi He et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Article Oncology

Randomized Clinical Trial Comparing Proton Beam Radiation Therapy with Transarterial Chemoembolization for Hepatocellular Carcinoma: Results of an Interim Analysis

David A. Bush et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

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Article Oncology

Analysis of therapeutic effectiveness and prognostic factor on argon-helium cryoablation combined with transcatheter arterial chemoembolization for the treatment of advanced hepatocellular carcinoma

Chen Huang et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2016)

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Article Oncology

Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone

Karen T. Brown et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Immunology

Predictors of Successful Downstaging of Hepatocellular Carcinoma Outside Milan Criteria

Arvind R. Murali et al.

TRANSPLANTATION (2016)

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Article Medicine, General & Internal

Living Donor Liver Transplantation for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis after Concurrent Chemoradiation Therapy

Dai Hoon Han et al.

YONSEI MEDICAL JOURNAL (2016)

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Article Multidisciplinary Sciences

Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients

Min Ding et al.

PLOS ONE (2016)

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Article Surgery

Complete Pathologic Response to Pretransplant Locoregional Therapy for Hepatocellular Carcinoma Defines Cancer Cure After Liver Transplantation Analysis of 501 Consecutively Treated Patients

Vatche G. Agopian et al.

ANNALS OF SURGERY (2015)

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Article Gastroenterology & Hepatology

Multicenter Randomized Controlled Trial of Percutaneous Cryoablation Versus Radiofrequency Ablation in Hepatocellular Carcinoma

Chunping Wang et al.

HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

Does pathological response after transarterial chemoembolization for hepatocellular carcinoma in cirrhotic patients with cirrhosis predict outcome after liver resection or transplantation?

Marc-Antoine Allard et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Gastroenterology & Hepatology

Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma

Frank T. Kolligs et al.

LIVER INTERNATIONAL (2015)

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Article Cardiac & Cardiovascular Systems

Randomized Comparison of Selective Internal Radiotherapy (SIRT) Versus Drug-Eluting Bead Transarterial Chemoembolization (DEB-TACE) for the Treatment of Hepatocellular Carcinoma

Michael B. Pitton et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2015)

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Article Oncology

Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma

Jiuwei Cui et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Article Gastroenterology & Hepatology

Increased survival in hepatocellular carcinoma with iodine-125 implantation plus radiofrequency ablation: A prospective randomized controlled trial

Kaiyun Chen et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparative evaluation of percutaneous laser and radiofrequency ablation in patients with HCC smaller than 4 cm

Antonio Orlacchio et al.

RADIOLOGIA MEDICA (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

Unresectable Hepatocellular Carcinoma: Randomized Controlled Trial of Transarterial Ethanol Ablation versus Transcatheter Arterial Chemoembolization

Simon Chun Ho Yu et al.

RADIOLOGY (2014)

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Article Surgery

Efficacy and survival analysis of percutaneous radiofrequency versus microwave ablation for hepatocellular carcinoma: an egyptian multidisciplinary clinic experience

Ashraf Abdelaziz et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2014)

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Article Oncology

A randomised phase II/III trial of 3-weekly cisplatin-based sequential transarterial chemoembolisation vs embolisation alone for hepatocellular carcinoma

T. Meyer et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Gastroenterology & Hepatology

Hypertonic saline-enhanced radiofrequency versus chemoembolization sequential radiofrequency in the treatment of large hepatocellular carcinoma

Nabeel M. El-Kady et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2013)

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Article Oncology

Radiofrequency Ablation With or Without Transcatheter Arterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Prospective Randomized Trial

Zhen-Wei Peng et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Oncology

Cytokine-induced Killer Cells in Combination With Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma Patients

Zhi-Mei Huang et al.

JOURNAL OF IMMUNOTHERAPY (2013)

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Article Gastroenterology & Hepatology

Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria

Christophe Duvoux et al.

GASTROENTEROLOGY (2012)

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Article Gastroenterology & Hepatology

The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma

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