期刊
SMALL STRUCTURES
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/sstr.202300198
关键词
diabetic wound healing; hydrogel dressing; manganese oxides; nanozymes; reactive oxygen species
The management of diabetic wounds is challenging due to bacterial infections and chronic inflammation. This study proposes a two-phase treatment strategy using reactive oxygen species (ROS) to combat infection and promote wound regeneration. The strategy effectively eliminates bacteria and stimulates wound healing.
The management of diabetic wounds poses significant challenges due to persistent bacterial infections and chronic inflammation caused by hyperglycemia. Herein, a sequential two-phase treatment strategy involving a reactive oxygen species (ROS) burst in the first phase for anti-infection is proposed, followed by a benign level of ROS in the second phase for wound regeneration. To this end, ultra-small manganese oxide nanodots (BM-NDs) are incorporated into a gelatin methacry-lamide (GelMA) hydrogel via a ROS-responsive linker to form GelMA@BM dressing. The BM-NDs catalyze a self-cascade reaction that decomposes glucose into hydrogen peroxide, generates hydroxyl radicals (.OH), and simultaneously depletes glutathione. Upon application on diabetic wounds, BM-NDs are rapidly released from the hydrogel due to endogenous ROS exposure, leading to high levels of .OH that effectively eliminate bacteria and promote macrophage polar-ization to M1 phenotype, thereby facilitating phagocytosis of bacteria. With the consumption of glucose and degradation of BM-NDs, ROS in the wound area declines to a benign level, which stimulates polarization of M2 macrophages and promotes wound healing. This two-phase treatment strategy based on GelMA@BM dressing demonstrates potent antibacterial and pro-healing efficacy, showcasing its potential for clinical translation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据