Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study

Editorial Material Oncology

ASO Author Reflections: Rethinking Radiation Associated Angiosarcoma of the Breast-Secondary Malignancies That Require Expert Care for Improved Outcomes

Andrea M. Covelli et al.

ANNALS OF SURGICAL ONCOLOGY (2022)

Article Oncology

Multidisciplinary Intervention in Radiation-Associated Angiosarcoma of the Breast: Patterns of Recurrence and Response to Treatment

Sheena Guram et al.

Summary: Patients with breast RAAS who received initial treatment by an SMDT underwent more extensive surgery and multimodal treatments, leading to better 3-year LRFS and lower recurrence rates.

ANNALS OF SURGICAL ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Clinical and Molecular Insights of Radiation-Induced Breast Sarcomas: Is There Hope on the Horizon for Effective Treatment of This Aggressive Disease?

Stefania Kokkali et al.

Summary: Radiation-induced breast sarcomas (RIBS) are rare malignancies, mainly high-grade angiosarcomas. Diagnosis and treatment are challenging, indicating the need for further research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Radiation-Induced Sarcoma: A Retrospective Population-Based Study Over 34 Years in a Single Institution

L. B. Callesen et al.

Summary: This retrospective study aimed to investigate the prevalence, patient characteristics, tumour characteristics, prognosis, and outcomes of patients with radiation-induced sarcomas (RIS) treated at the Sarcoma Centre at Aarhus University Hospital over a 34-year period. Results showed that RIS patients have unique epidemiological and tumour characteristics, with a poor prognosis, highlighting the need for further research into new intensive treatment strategies to improve outcomes.

CLINICAL ONCOLOGY (2021)

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Article Oncology

Radiation-Induced Sarcoma of the Head and Neck Following Radiotherapy for Nasopharyngeal Carcinoma: A Single Institutional Experience and Literature Review

Jianlin Lou et al.

Summary: This study aimed to investigate clinicopathological features and head and neck radiation-induced sarcomas (RIS) prognosis after nasopharyngeal carcinoma (NPC) radiotherapy, finding that R0 resection significantly improves prognosis, and patients under the age of 37 at the time of initial radiotherapy have a relatively better prognosis.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites

Anson Snow et al.

Summary: This study demonstrated that breast cancer patients have a higher risk of developing radiation-induced sarcomas (RIS) compared to patients with other solid cancers, based on a retrospective cohort study using SEER database data from 1973 to 2013.

CANCER EPIDEMIOLOGY (2021)

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Article Oncology

Metastatic Myxofibrosarcoma with Durable Response to Temozolomide Followed by Atezolizumab: A Case Report

Jason P. Lambden et al.

Summary: This case represents the first report of a patient with myxofibrosarcoma with a high tumor mutational burden after receiving temozolomide monotherapy. Hypermutation may serve as a resistance mechanism for soft tissue sarcoma patients who develop resistance to alkylating agents. Checkpoint inhibition may be an effective therapy for soft tissue sarcoma patients with high tumor mutational burden due to alternate systemic therapy resistance.

ONCOLOGIST (2021)

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Review Oncology

Immunotherapy for sarcomas: new frontiers and unveiled opportunities

Harsimrat Kaur Birdi et al.

Summary: Sarcomas, a rare malignancy of mesenchymal tissues with over 60 subtypes, pose challenges in treatment due to disease heterogeneity. While traditional therapies are effective in early stages, immunotherapy is showing promise for advanced sarcoma treatment, sparking interest in further research and application.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Medicine, General & Internal

The Management of Radiation-Induced Sarcomas: A Cohort Analysis from a Sarcoma Tertiary Center

Mateusz Jacek Spalek et al.

Summary: This study confirms the poor prognosis of radiation-induced sarcomas and highlights the importance of locally curative treatments for prognosis. Based on univariate analysis, tumor localization and treatment with curative intent are associated with a lower risk of death.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal