RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors

Article Biochemistry & Molecular Biology

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo et al.

Summary: Research has identified CDK2 as a key host factor in SARS-CoV-2 RNA replication, facilitating viral RNA synthesis, and CDK2 inhibitors have shown potential in impairing viral replication and infection.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Virology

SARS-CoV-2 and SARS-CoV: Virtual screening of potential inhibitors targeting RNA-dependent RNA polymerase activity (NSP12)

Zijing Ruan et al.

Summary: The novel coronavirus (SARS-CoV-2) has caused a global pandemic, with over six million people infected worldwide. Despite the lack of officially licensed drugs, the NSP12-NSP7-NSP8 complex is identified as a potential target for fighting the virus, with virtual screening and docking scores showing promising results for eight selected compounds.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Microbiology

The SARS-CoV-2 RNA-protein interactome in infected human cells

Nora Schmidt et al.

Summary: Characterizing the interactions between SARS-CoV-2 viral RNAs and host cell proteins during infection can enhance our understanding of viral RNA functions and the host innate immune response. Identification of specific host proteins that restrict viral replication and exploring defense strategies will aid in the development of targeted therapeutics against SARS-CoV-2.

NATURE MICROBIOLOGY (2021)

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Article Immunology

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

Wenjing Wang et al.

Summary: The study found that SARS-CoV-2 nsp12 suppresses host antiviral responses by attenuating specific IFN promoter activation and impacting the function of IRF3. These findings provide new insights into the viral pathogenesis.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

Kris M. White et al.

Summary: The study revealed that plitidepsin possesses potent antiviral activity against SARS-CoV-2, more effective than the approved drug remdesivir. By inhibiting the eukaryotic translation elongation factor 1A, plitidepsin can significantly reduce viral replication of SARS-CoV-2 in the lungs of mice, making it a promising candidate for COVID-19 treatment.

SCIENCE (2021)

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Article Genetics & Heredity

Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation

Xiuye Wang et al.

Summary: This study reveals that HSV-1 infection causes widespread changes in host mRNA APA with the involvement of ICP27, leading to intronic polyadenylation and early termination of RNAPII. These changes contribute to altered gene expression patterns and the expression of truncated mRNAs, suggesting a multi-faceted host response to viral infection and cellular stress.

PLOS GENETICS (2021)

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Review Biochemistry & Molecular Biology

Type I and III interferon responses in SARS-CoV-2 infection

You-Me Kim et al.

Summary: Researchers have reviewed how SARS-CoV-2 manipulates the immune system by inhibiting host IFN responses, leading to delayed and exaggerated inflammation, which contributes to the severity of COVID-19. Further investigations are needed to better understand the mechanisms behind these immune system dysfunctions caused by the virus.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

The SARS-CoV-2 RNA interactome

Sungyul Lee et al.

Summary: The study reveals the interactions between SARS-CoV-2 and host RNA-binding proteins, provides a comprehensive list of RBPs regulating coronaviral replication, and opens new avenues for therapeutic interventions.

MOLECULAR CELL (2021)

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Article Multidisciplinary Sciences

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

Pramod R. Bhatt et al.

Summary: This study revealed the key event of programmed ribosomal frameshifting during translation of SARS-CoV-2, validated the importance of frameshifting for viral RNA synthesis through structural observations and biochemical experiments, and identified mechanistic and regulatory features influencing frameshifting efficiency.

SCIENCE (2021)

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Review Cell Biology

Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19

Rohitash Yadav et al.

Summary: Coronavirus, including SARS-CoV-2, has a high sequence similarity with bat-related coronaviruses and has a greater affinity for host cell receptors, leading to pathogenic processes. The translation of viral RNA into proteins and the assembly of functional components play a crucial role in the virus's replication and infection mechanism.

CELLS (2021)

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Article Biophysics

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication

Mateusz Wilamowski et al.

Summary: The replication transcription complex (RTC) of the virus SARS-CoV-2 plays a crucial role in copying viral RNA and transcribing viral proteins. Through systematic structural investigations and various biophysical techniques, researchers have gained deeper insights into the assembly, mechanism, and potential disruption of RTC and its functions.

BIOPHYSICAL JOURNAL (2021)

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Article Medicine, Research & Experimental

Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin

Guilherme Dias de Melo et al.

Summary: This study demonstrates that ivermectin can prevent clinical deterioration and reduce inflammation in the respiratory tracts of SARS-CoV-2-infected hamsters through immunomodulatory pathways, suggesting its potential to improve the clinical condition of patients infected with SARS-CoV-2.

EMBO MOLECULAR MEDICINE (2021)

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Article Virology

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist

Aixin Li et al.

Summary: Our study revealed that while NSP12 could suppress IFN-beta promoter luciferase activity, it did not inhibit IFN-beta production or downstream signaling. Additionally, caution is needed when interpreting SARS-CoV-2-related luciferase assays due to potential contradictory results from different experimental systems.

JOURNAL OF VIROLOGY (2021)

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Letter Medicine, General & Internal

Hospital-acquired SARS-CoV-2 infection in the UK's first COVID-19 pandemic wave

Jonathan M. Read et al.

LANCET (2021)

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Review Biochemistry & Molecular Biology

Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches

Hany E. Marei et al.

Summary: Efforts are being made to develop efficient vaccines and treatments for SARS-CoV-2 infection, with therapeutic strategies focusing on inhibiting virus replication, enhancing immunity, and relieving COVID-19 symptoms. Multiple clinical trials are ongoing to assess the efficacy of antiviral substances, while vaccination campaigns using various vaccines are underway worldwide with efficacy rates between 72-95%. Further research and data are needed to confirm the safety of available vaccines.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Microbiology

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

Magen Ellen Francis et al.

Summary: COVID-19 is a disease caused by SARS-CoV-2 infection that affects multiple organ systems, including the respiratory tract, urinary tract, neurological system, and cardiovascular system. Understanding the host immune responses in these systems is crucial for studying the disease and potential therapies. Inflammatory cytokines were increased while type I interferons were inhibited, indicating the complex immune responses contributing to multiorgan disease in COVID-19 patients and potentially in those with post-acute sequelae of SARS-CoV-2.

PLOS PATHOGENS (2021)

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Article Biochemistry & Molecular Biology

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Jin-Lan Zhang et al.

Summary: FNC, a nucleoside analog, has shown activity against HIV-1 and SARS-CoV-2. Research suggests FNC's anti-viral effect is concentrated in the thymus, promoting immunity. Clinical trials have demonstrated oral FNC's ability to effectively cure COVID-19 patients.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Immunology

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Ronen Alon et al.

Summary: The understanding of COVID-19 clinical manifestations requires knowledge of how immune cells are recruited to virus-infected lungs and how this recruitment varies among individuals. The orchestration of leukocyte trafficking to respiratory system is controlled by specific molecules, which can lead to pathological complications when uncontrolled. The incomplete understanding of trafficking signals in response to SARS-CoV-2 infection calls for further research for potential therapeutic interventions.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Abhik K. Banerjee et al.

CELL (2020)

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Article Multidisciplinary Sciences

Activation and evasion of type I interferon responses by SARS-CoV-2

Xiaobo Lei et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Inflammation, Thrombosis, and Destruction: The Three-Headed Cerberus of Trauma- and SARS-CoV-2-Induced ARDS

Ludmila Lupu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Chemistry, Physical

Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study

Padmaja D. Wakchaure et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2020)

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Review Immunology

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

Mei-Yue Wang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Virology

Role of Enteroviral RNA-Dependent RNA Polymerase in Regulation of MDA5-Mediated Beta Interferon Activation

Rei-Lin Kuo et al.

JOURNAL OF VIROLOGY (2019)

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Article Biochemistry & Molecular Biology

A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis

Peng Dai et al.

CELL (2019)

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Article Immunology

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

Xia Li et al.

NATURE IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Ankyrin Repeat Domain 1 is Up-regulated During Hepatitis C Virus Infection and Regulates Hepatitis C Virus Entry

Thoa T. Than et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

Kathleen C. Lehmann et al.

NUCLEIC ACIDS RESEARCH (2015)

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Review Oncology

The eEF1A proteins: at the crossroads of oncogenesis, apoptosis, and viral infections

Wasim Abbas et al.

FRONTIERS IN ONCOLOGY (2015)

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Review Pharmacology & Pharmacy

Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development

Celia Caillet-Saguy et al.

ANTIVIRAL RESEARCH (2014)

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Article Immunology

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

Juan Liu et al.

NATURE IMMUNOLOGY (2014)

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Article Biochemical Research Methods

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

Michael J. Moore et al.

NATURE PROTOCOLS (2014)

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Article Biochemical Research Methods

iCLIP: Protein-RNA interactions at nucleotide resolution

Ina Huppertz et al.

METHODS (2014)

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Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

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Review Microbiology

The Unexpected Roles of Eukaryotic Translation Elongation Factors in RNA Virus Replication and Pathogenesis

Dongsheng Li et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2013)

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Article Multidisciplinary Sciences

MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation

Rei-Lin Kuo et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

Kylie Warren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Biochemical Research Methods

BamTools: a C++ API and toolkit for analyzing and managing BAM files

Derek W. Barnett et al.

BIOINFORMATICS (2011)

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Article Multidisciplinary Sciences

Single-Base Pair Unwinding and Asynchronous RNA Release by the Hepatitis C Virus NS3 Helicase

Wei Cheng et al.

SCIENCE (2011)

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Article Biotechnology & Applied Microbiology

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Ben Langmead et al.

GENOME BIOLOGY (2009)

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Article Virology

Identification of residues critical for the interferon antagonist function of langat virus NS5 reveals a role for the RNA-dependent RNA polymerase dornainv

Gregory S. Park et al.

JOURNAL OF VIROLOGY (2007)

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Article Biochemical Research Methods

Immunoprecipitation of mRNA-protein complexes

Tiina Peritz et al.

NATURE PROTOCOLS (2006)

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RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors

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