期刊
C-JOURNAL OF CARBON RESEARCH
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/c9030072
关键词
activated carbon; activated charcoal; sepsis; inflammation; pathogen-associated molecular patterns; damage-associated molecular patterns
This article introduces the application of activated carbon or charcoal in alleviating inflammation and explains its mechanisms of protecting the microbiome and bone marrow, as well as its anti-inflammatory and anti-oxidant effects. Early application of activated carbon and its high adsorption capacity are essential in the treatment of preventing sepsis and multi-organ failure.
(1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or charcoal (AC) of new generation with ameliorated biocompatibility has spurred renewed interest in the regulation of these toxins' levels in inflammation states. (2) Methods: We searched PubMed, Google Scholar, ScienceDirect, Researchgate, and other sources for the relevant literature from 1550 B.C. till 2022 A.C. (3) Results: Laboratory and clinical investigations demonstrate that activated carbon or charcoal (AC) mitigates inflammation in different pathological states when applied orally, per rectum, or in a hemoperfusion system. AC protects the microbiome and bone marrow, acts as an anti-inflammatory and anti-oxidant remedy, and recovers the plasmatic albumin structure. The mechanism of AC action is related to a non-selective (broad-range) or/and selective adsorption of PAMPs & DAMPs from biological fluids. A high-adsorptive capacity towards noxious substances and application of AC as early as possible seems paramount in inflammation treatment for preventing sepsis and/or multi-organ failure. (4) Conclusion: AC could be considered an adjunctive treatment for preventing sepsis and/or multi-organ failure.
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