期刊
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
卷 366, 期 1, 页码 38-43出版社
ELSEVIER SCIENCE INC
关键词
Basal-bolus insulin; Premixed insulin; Type 2 diabetes
This study aimed to compare diabetes-related outcomes between basal-bolus and premixed insulin regimens. The results showed no significant differences in glycemic control, hypoglycemia rate, or BMI between the two groups after one year of treatment. This suggests that premixed insulin is equally effective and safe as basal-bolus insulin.
Background : Thepurposeofthisstudywastocomparediabetes(DM)-relatedoutcomesbetweenbasal-bolus(BB) andpremixed( PM) insulinregimens. Methods: Retrospectivechartreviewincludingveteranswithtype2diabetes(T2DM),>= 18yearsoldwithhemoglobinA1c( HbA1c)>= 8%. OutcomeswereassessedafteroneyearofBBorPMinsulintherapy. DatawereanalyzedusingChi-square/ Fisherexacttestsandlogisticregression. Results: Outof140enrolledsubjects(70BBand70PM), 94% weremaleswithaverageageanddurationofDMof65.7 +/- 10.1and12.9 +/- 9years, respectively. TheBBandPMgroupsweresimilarinage, genderdistribution, HbA1c, bodymassindex( BMI) andDMdurationatbaseline. Following1yearoftreatment, therewasnosignificantdifferencebetweenthegroupsforchangeinHbA1c(-1.9 +/- 1.8vs-2.1 +/- 1.9%, p= 0.3) orhypoglycemiarate(30% vs21.4%, p= 0.3), respectively. TherewassimilarincreaseinaverageBMIinbothgroups(0.84 +/- 3.1forBBvs0.4 +/- 2.2kg/m2forPM, p= 0.2). Conclusions: Therewerenosignificantdifferencesforglycemiccontrol, hypoglycemiarateorBMIbetweentheBBorPMinsulingroups. TheseresultssuggestPMinsulinisequallyeffectiveandsafeasBBinsulin.
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