期刊
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
卷 18, 期 5, 页码 486-491出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1386207318666150424104452
关键词
4-hydroxycoumarin; acetylenic compounds; N-nucleophiles; solvent-free
An efficient and selective synthesis of substituted chromene derivatives via three-component reaction of 4-hydroxycoumarin or 1,3-dicarbonyl compounds, activated acetylenic compounds and N-nucleophiles is described. The reaction was conducted under solvent-free conditions at 70 degrees C using potassium fluoride impregnated on natural zeolite as a cheap and available solid base. The procedure has several advantages involving selectivity, excellent yields and a convenient work-up method.
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