期刊
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
卷 18, 期 5, 页码 505-513出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1386207318666150430114815
关键词
Apoptosis; benzofuran derivative; Cytotoxicity; MCF-7 breast cancer cell line; petasites hybridus
资金
- Research Council of Golestan University of Medical Science
This study was focused on evaluation of the cytotoxicity and apoptotic affects of benzofuran derivative on MCF-7 breast cancer cell line. This effective compound was isolated from the root of Petasites hybridus plant. For experiments, the MCF-7 cells were treated with several concentrations (0-500 mu M) of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone 1 at different times. In this study, test of neutral red was also employed for cytotoxicity assay and quantity of P53, P21. Bax genes expression was analyzed using Real-Time PCR and ELISA techniques. Results show that compound 1 has cytotoxicity and apoptotic effects on Human breast cancer (Michigan Cancer Foundation-7) MCF-7 cells.
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