☆ 4.6 Article

Synthesis of NMN by cascade catalysis of intracellular multiple enzymes

RSC ADVANCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

Nicotinamide mononucleotide restores oxidative stress-related apoptosis of oocyte exposed to benzyl butyl phthalate in mice

Yi Jiang et al.

Summary: This study investigated the specific influence of benzyl butyl phthalate (BBP) on mouse oocyte maturation using in vivo and in vitro models. The results showed that BBP exposure significantly affected the rate of oocyte exclusion of the first polar body and blastocyst rate. Further analysis revealed that BBP disrupted mitochondrial function and induced oxidative stress-induced early apoptosis, while nicotinamide mononucleotide (NMN) supplementation reduced the adverse effects of BBP.

CELL PROLIFERATION (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metabolic Engineering of Bacillus licheniformis for the Bioproduction of Nicotinamide Riboside from Nicotinamide and Glucose

Menglin Zhou et al.

Summary: In this study, Bacillus licheniformis was engineered to efficiently produce nicotinamide riboside (NR) from glucose and nicotinamide. Through genetic modifications, the production of NR was significantly increased, and a yield of 11.33 g/L NR was achieved in shake flask cultures. This genetically modified strain holds great promise for the cost-effective and high-quality industrial production of NR.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2023)

添加到收藏夹

Article Chemistry, Physical

Design of an in vitro multienzyme cascade system for the biosynthesis of nicotinamide mononucleotide

Cailian Zhou et al.

Summary: Three artificial pathways were designed and successfully conducted to produce nicotinamide mononucleotide (NMN) in vitro. The adenosine phosphate hydrolysis (APH) pathway exhibited the highest level of NMN synthesis. By screening different enzymes and optimizing the catalysis system, the NMN titer was significantly increased. This is the first study to use a multienzyme cascade catalysis process for NMN biosynthesis.

CATALYSIS SCIENCE & TECHNOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Biosynthesis of allantoin in Escherichia coli via screening a highly effective urate oxidase

Fengjuan Zhang et al.

Summary: In this study, an artificial biosynthetic pathway for allantoin production was successfully constructed. Through optimization of conditions and yield improvement, large-scale production of allantoin was achieved. This study not only has important industrial applications but also provides a platform for the synthesis of other high-value purine-derived compounds.

BIOTECHNOLOGY AND BIOENGINEERING (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Surfactants, Biosurfactants, and Non-Catalytic Proteins as Key Molecules to Enhance Enzymatic Hydrolysis of Lignocellulosic Biomass

Salvador Sanchez-Munoz et al.

Summary: This review describes the mechanisms, roles, and effects of using additives in the enzymatic hydrolysis process of lignocellulosic biomass, providing a technical background to address operational hurdles in biomass processing.

MOLECULES (2022)

添加到收藏夹

Article Biochemical Research Methods

Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide

Zhongshi Huang et al.

Summary: Research studies have confirmed the crucial role of NAD(+) in aging and disease. This study successfully established a biocatalytic method for the efficient synthesis of NMN, a key intermediate of NAD(+), demonstrating high yield production through gene expression and copy number modulation.

ACS SYNTHETIC BIOLOGY (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Biological synthesis of nicotinamide mononucleotide

Qi Shen et al.

Summary: NMN is a nucleotide that can be converted into NAD in human cells, and has attracted attention as a potential anti-aging drug. The chemical synthesis of NMN is challenging, involving the use of the intermediate PRPP and enzymes for conversion.

BIOTECHNOLOGY LETTERS (2021)

添加到收藏夹

Article Biochemical Research Methods

Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of Escherichia coli

Anoth Maharjan et al.

Summary: The study successfully constructed a recombinant strain of E. coli with inserted NAMPT, PRPS1, and PRPS2 genes, achieving efficient NMN production in batch fermentation studies. Further investigation showed that supplementation of ribose, Mg2+, phosphate, nicotinamide, and lactose inducer led to a significant increase in NMN production levels.

ACS SYNTHETIC BIOLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide

Shinichiro Shoji et al.

Summary: A whole-cell biocatalyst using Escherichia coli was developed for efficient production of Nicotinamide mononucleotide (NMN) from inexpensive substrates glucose and nicotinamide, achieving high yields and selectivity. The approach identified functional transporters and key enzymes allowing for intracellular uptake, conversion, and extracellular excretion of NMN. This method shows promise for low-cost, high-quality industrial production of NMN and other nucleotide compounds using microorganisms.

METABOLIC ENGINEERING (2021)

添加到收藏夹

Article Biophysics

Crystal structure of E-coli PRPP synthetase

Weijie Zhou et al.

BMC STRUCTURAL BIOLOGY (2019)

添加到收藏夹

Review Cell Biology

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Jun Yoshino et al.

CELL METABOLISM (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

Chun-Chun Wei et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Neurosciences

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

Xiaonan Wang et al.

BRAIN RESEARCH (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Normalization of NAD+ Redox Balance as a Therapy for Heart Failure

Chi Fung Lee et al.

CIRCULATION (2016)

添加到收藏夹

Article Neurosciences

Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia

Ji H. Park et al.

NEUROBIOLOGY OF DISEASE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

Takanobu Yamamoto et al.

PLOS ONE (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Biocatalytic ketone reduction -: a powerful tool for the production of chiral alcohols -: part I:: processes with isolated enzymes

Katja Goldberg et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.