Synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes by cross-coupling induced by transition metals - formation of C-C bonds

The synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs), by forming a C-C bond, can be achieved by cross-coupling reactions using transition metal catalysts. Two main strategies are described to access these 1,3-disubstituted BCPs, either from nucleophilic BCPs or electrophilic BCPs. Mechanisms are included where relevant. The synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs), by forming a C-C bond, can be achieved by cross-coupling reaction using transition metal catalysts.

Automated summary

This article introduces the synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs) by forming a C-C bond through cross-coupling reactions using transition metal catalysts. Two main strategies are described to obtain these compounds from nucleophilic BCPs or electrophilic BCPs, including relevant mechanisms.