期刊
ANIMAL
卷 17, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.animal.2023.100828
关键词
Gametogenesis; Germ cells; Gonads; In vitro breeding; Pluripotency
The goal of in vitro gametogenesis is to reproduce the development of sperm and oocytes in the laboratory. Recent research in mice and humans has revealed species-specific differences in germ cell development, with potential applications in optimizing livestock genetics. Embryonic stem cells have been identified as promising candidates for studying germ cells.
The goal of in vitro gametogenesis is to reproduce the events of sperm and oocyte development in the laboratory. Significant advances have been made in the mouse in the last decade, but evolutionary divergence from the murine developmental program has prevented the replication of these advances in large mammals. In recent years, intensive work has been done in humans, non-human primates and livestock to elucidate species-specific differences that regulate germ cell development, due to the number of potential applications. One of the most promising applications is the use of in vitro gametes to optimize the spread of elite genetics in cattle. In this context, embryonic stem cells have been posed as excellent candidates for germ cell platforms. Here, we present the most relevant advances in in vitro gametogenesis of interest to livestock science, including new types of pluripotent stem cells with potential for germline derivation, characterization of the signaling environment in the gonadal niche, and experimental systems used to reproduce different stages of germ cell development in the laboratory. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of The Animal Consortium. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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