4.5 Review

Current complementary and alternative therapy forgastroesophageal reflux disease

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Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study

Chen Hao-yu et al.

Summary: This study aimed to identify specific Chinese medicines that may benefit patients with GERD and explore their action mechanism. The results showed that Evodiae Fructus and Coptidis Rhizoma are the core drugs in the treatment of GERD, and their potential mechanism of action involves multiple pathways.

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Current management of gastro-oesophageal reflux disease-treatment costs, safety profile, and effectiveness: a narrative review

Tahmina Lata et al.

Summary: This study aimed to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile, and effectiveness. It found widespread overprescribing of proton pump inhibitors (PPIs) in Western and Eastern nations, with observational associations of adverse effects with long-term PPI use. Laparoscopic fundoplication is supported as a long-term management option for PPI-responsive GORD and PPI-refractory GORD. The importance of establishing a definitive diagnosis before invasive management, especially in PPI-refractory heartburn, is emphasized.

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ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease

Philip O. Katz et al.

Summary: This article provides updated recommendations and practical guidance for the evaluation and management of GERD, including pharmacologic, lifestyle, surgical, and endoscopic management. The use of proton pump inhibitors (PPIs) has raised concerns about long-term safety and overprescribing. New data regarding surgical and endoscopic interventions have also emerged.

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Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study

Shuai Yuan et al.

Summary: Observational studies have shown associations between adiposity, diabetes, and lifestyle factors with gastroesophageal reflux disease (GERD). This study used Mendelian randomization analysis and found causal roles of adiposity, diabetes, and smoking, and a possible role of high caffeine consumption in the development of GERD.

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Prevalence and beverage-related risk factors of gastroesophageal reflux disease: An original study in Chinese college freshmen, a systemic review and meta-analysis

Youli Chen et al.

Summary: The prevalence of GERD among Chinese college freshmen is 5.1%, which is significantly lower than that in worldwide youth populations. Drinking green tea and coffee daily may increase the risk of developing GERD in young individuals. The pooled prevalence of GERD in young populations is 18.0%, and frequent alcohol consumption is positively associated with GERD in the general population.

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The Effect of Rice vs. Wheat Ingestion on Postprandial Gastroesophageal Reflux (GER) Symptoms in Patients with Overlapping GERD-Irritable Bowel Syndrome (IBS)

Tanisa Patcharatrakul et al.

Summary: A randomized crossover study found that wheat noodles induced more GERD symptoms than rice noodles in patients with overlapping GERD-IBS, which may be associated with increased intestinal gas production. A low FODMAPs diet may help relieve postprandial GERD symptoms in these patients.
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A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction

Laurie Keefer et al.

Summary: This report summarizes the consensus and methods of an international expert team regarding the use of behavioral interventions in patients with DGBIs. By reviewing existing scientific literature, the committee confirmed the definition and evidence of BGBT, connecting it with DGBI-specific behavioral targets and techniques to support clinical decision-making in providing BGBT.

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Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux: A Double-Blind, Randomized, Sham-Controlled Trial

Jeroen M. Schuitenmaker et al.

Summary: This study evaluated the effects of a novel electronic sleep positional therapy wearable device on sleep position and nocturnal reflux symptoms. The results showed that using the device promoted sleeping in the left lateral decubitus position, reduced time spent sleeping in the right lateral position, and effectively alleviated nocturnal reflux symptoms.

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The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial

Gu Cihang et al.

Summary: This study is the first randomized controlled diet intervention trial to investigate the impact of both the amount and type of carbohydrate on symptomatic gastroesophageal reflux disease (GERD). The results showed that reducing the intake of simple sugars improved pH monitoring outcomes and symptoms of GERD. These findings provide feasible and clinically applicable dietary recommendations for the treatment and management of GERD.

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Elimination of Dietary Triggers Is Successful in Treating Symptoms of Gastroesophageal Reflux Disease

Cesare Tosetti et al.

Summary: Most patients with GERD can identify at least one food triggering their symptoms, with common trigger foods being spicy foods, chocolate, pizza, tomato, and fried foods. Eliminating these foods may lead to an improvement in symptoms for patients.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Effects of Diaphragmatic Breathing on the Pathophysiology and Treatment of Upright Gastroesophageal Reflux: A Randomized Controlled Trial

Magnus Halland et al.

Summary: The study showed that diaphragmatic breathing can reduce the number of postprandial reflux events in patients with upright GERD by increasing the difference between LES and gastric pressure. These findings support further investigation of diaphragmatic breathing as a therapy for GERD.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

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Association of Diet and Lifestyle With the Risk of Gastroesophageal Reflux Disease Symptoms in US Women

Raaj S. Mehta et al.

Summary: This cohort study examined the combined impact of dietary and lifestyle factors on the risk of gastroesophageal reflux disease symptoms in women participating in the Nurses' Health Study II.

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Integrative Effects and Vagal Mechanisms of Transcutaneous Electrical Acustimulation on Gastroesophageal Motility in Patients With Gastroesophageal Reflux Disease

Bo Zhang et al.

Summary: The study indicates that TEA treatment can significantly improve symptoms in patients with GERD, increase DCI, reduce ineffective esophageal contractions during wet swallows, and improve gastric accommodation and slow waves.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

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Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment

Sheng Chen et al.

Summary: Innovations in endoscopy have significantly improved the diagnosis and treatment of GERD. Endoscopy and biopsies can directly observe and determine esophageal abnormalities. Future research should focus on personalized treatment and the primary pathophysiology of GERD.

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JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study

Jiaqi Zhang et al.

Summary: In patients with nonerosive reflux disease (NERD), the combination of JQ granules with omeprazole (10 mg) was found to be more effective in symptom relief compared to omeprazole (20 mg). The combination therapy was associated with a higher rate of liver dysfunction and improved richness and diversity of the gut microbiota.

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Dietary and Lifestyle Factors Related to Gastroesophageal Reflux Disease: A Systematic Review

Mei Zhang et al.

Summary: The study revealed that various unhealthy dietary and lifestyle habits impact the onset of GERD differently across regions and disease types. Further research is needed to confirm these findings.

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Umbrella review of 42 systematic reviews with meta-analyses: the safety of proton pump inhibitors

Elizabeth M. Salvo et al.

Summary: This study identified several associations between PPIs and adverse outcomes, but the certainty for most outcomes was very low, indicating further research is needed. If higher quality evidence substantiating the potential risks of PPIs is generated, clinicians may need to consider alternative treatment strategies.

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Shere Paris et al.

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Summary: The study found that both a low FODMAP diet and usual dietary advice had similar but limited beneficial effects on symptoms in patients with PPI refractory GERD.

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Modified Xiaochaihu Decoction for gastroesophageal reflux disease: A randomized double-simulation controlled trial

Zhe Li et al.

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