Chitosan/silk fibroin nanofibers-based hierarchical sponges accelerate infected diabetic wound healing via a HClO self-producing cascade catalytic reaction

Review Microbiology

Molecular mechanisms of antibiotic resistance revisited

Elizabeth M. Darby et al.

Summary: Antibiotic resistance is a global health emergency, and understanding the molecular mechanisms that bacteria use to resist antimicrobials is critical. Recent advances in research can aid in developing new antimicrobial therapies.

NATURE REVIEWS MICROBIOLOGY (2023)

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Article Chemistry, Multidisciplinary

Glycopeptide-Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

Hao Xia et al.

Summary: Excessive inflammation, bacterial infection, and blocked angiogenesis pose challenges to diabetic wound healing. This study presents a novel approach using a glycopeptide-based hydrogel to regulate the pH microenvironment in diabetic wound sites. The hydrogel demonstrates anti-inflammatory effects and promotes angiogenesis, leading to effective diabetic wound repair and skin regeneration.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Chemistry, Multidisciplinary

A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections

Fan Zhao et al.

Summary: Biofilm infection in chronic wounds is common and delays wound healing. This paper describes a highly effective electrical antibiofilm treatment system that uses high-intensity current to debride biofilm and enhance antibiotic delivery. The system reduces bacterial count of MRSA biofilm-infected ex vivo skin wounds and demonstrates in vivo antibiofilm efficacy in a diabetic mouse-based wound infection model. This novel technology provides a quick, safe, and highly efficacious treatment for chronic wound biofilm infections.

ADVANCED MATERIALS (2023)

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Article Engineering, Environmental

Thermally insulating and electroactive cellular nanocellulose composite cryogels from hybrid nanofiber networks

Yi Hu et al.

Summary: This study introduces a simple strategy to synthesize high-performance cryogels that combine cellulose and silica nanofibers to form ice-templated cellular architectures. These cryogels exhibit high mechanical strength, compressibility, fatigue resistance, and low thermal conductivity. Moreover, they also possess electrical responsiveness and can operate under extreme conditions.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Engineering, Biomedical

Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

Zhipeng Zhou et al.

Summary: Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication. A natural adhesive from snail mucus has been discovered to promote skin wound healing. A double-network hydrogel biomaterial composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA) was developed, which exhibited strong tissue adhesion, anti-inflammatory activity, and biocompatibility. The AFG/GelMA hydrogel effectively promoted chronic wound healing.

BIOMATERIALS (2023)

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Article Engineering, Environmental

A simple yet effective hydrogel dressing for advanced microenvironmental management of diabetic wounds with intrinsic regulation

Kun Liu et al.

Summary: This study developed a photocrosslinked chitosan hydrogel with multiple functionalities for clinical diabetes wound healing. The hydrogel showed good adhesion, photo-induced self-healing, and responsiveness to pH, H2O2, and glucose. Compared to traditional injectable methacrylated chitosan hydrogel, the LAMC hydrogels were able to regulate the wound environment and create a favorable microenvironment for healing.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Engineering, Environmental

A compressible and underwater superelastic hydrophilic molecularly imprinted resin composite cellulose nanofiber aerogel to separate and purify catechins from tea

Yanmei Ma et al.

Summary: In this work, high-performance cellulose nanofiber aerogels (CNF AG) were prepared as a carrier, and MIRs@CNF AG were prepared by loading molecularly imprinted resins (MIRs) through in-situ polymerization. The prepared MIRs@CNF AG showed good adsorption capacity, selectivity, and reusability for separating and purifying catechin from tea.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Engineering, Environmental

Efficient recovery of highly viscous crude oil spill by superhydrophobic ocean biomass-based aerogel assisted with solar energy

Yihao Guan et al.

Summary: We propose a biodegradable marine bio-based aerogel (PDMS-Ink@CS) with excellent photothermal conversion and oil adsorption performance. Under simulated sunlight, it can absorb crude oil 18 times its weight within 60 s and recover via extrusion. Combined with a vacuum pump device, it realizes the continuous recovery of crude oil from the seawater surface. With a biodegradation period of 30 days, this super-hydrophobic ocean biomass-based chitosan aerogel shows vast potential for oil spill recovery applications.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Engineering, Biomedical

Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission

Yue Zhang et al.

Summary: Chronic diabetic wounds are a globally recognized clinical challenge, and this study found that using exosome-based bioactive dressings as an alternative method for diabetic wound healing has great potential. However, research on multifunctional hydrogels loaded with drugs and bioactive substances that synergistically promote wound repair is lacking, and the mechanism of their combinatorial effect remains unclear.

BIOACTIVE MATERIALS (2023)

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Article Engineering, Environmental

Photothermal-triggered release of alkyl radicals and cascade generation of hydroxyl radicals via a versatile hybrid nanocatalyst for hypoxia-irrelevant synergistic antibiofilm therapy

Huan Li et al.

Summary: Researchers have developed a dual free radical nanogenerator that can effectively treat bacterial biofilm infections. This nanogenerator can function in the microenvironments of hypoxia and over-expressed glutathione, improving its biomedical applications.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Materials Science, Multidisciplinary

Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion

Lei Liu et al.

Summary: Excessive exudate at wound sites poses challenges to wound treatment. In this study, a trilayered fibrous dressing with a stable wettability gradient was constructed by electrospinning polyurethane and polyvinylidene fluoride onto cotton fabric. The dressing exhibited rapid unidirectional transport and high hydrostatic pressure, allowing for efficient exudate removal. In vivo experiments showed that the trilayered dressing can accelerate wound healing, especially in the early stages of wound occurrence.

ADVANCED FIBER MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Biomimetic Aligned Micro-/Nanofibrous Composite Membranes with Ultrafast Water Transport and Evaporation for Efficient Indoor Humidification

Jingxiu Chen et al.

Summary: A biomimetic micro-/nanofibrous composite membrane with highly aligned fibrous structure and tailored surface wettability was developed for high-efficiency indoor humidification, demonstrating outstanding wicking height, water absorption, evaporation rate, and humidification capacity, surpassing commercial nonwoven membranes by 57%. This innovative membrane design provides new insights into the development of micro-/nanofibrous humidifying membranes for personal comfort and industrial productivity.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes

Bitao Lu et al.

Summary: Inspired by torpedoes, researchers developed a novel strategy to deliver hemostats into deep wounds using microcluster colloidosomes equipped with magnetic-mediated navigation and blast systems. The study demonstrated rapid and effective hemostasis in a vase-type hemorrhage model, and also showed excellent biodegradability in vivo.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy

Miaomiao Han et al.

Summary: In this study, a simple and rapid phase-transitioned albumin biomimetic nano-corona (TBSA) was used to camouflage the surface of polydopamine (PDA) nanoparticles for minimal plasma protein fouling and efficient photothermal therapy (PTT) of tumors. The TBSA coating improved the blood compatibility of PDA and increased its accumulation in tumor tissue, resulting in excellent photothermal antitumor effect compared to PDA alone. Additionally, PDA@TBSA treatment did not cause significant inflammatory response and tissue damage.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Glucose-responsive multifunctional metal-organic drug-loaded hydrogel for diabetic wound healing

Jiaxin Yang et al.

Summary: In this study, a glucose-responsive multifunctional metal-organic drug-loaded hydrogel (DG@Gel) was designed for diabetic wound healing. The hydrogel changed the hyperglycemic wound microenvironment, exhibited antibacterial and angiogenic activity, and showed good biocompatibility and biodegradability in vivo.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Environmental

Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique

Chengyuan Sun et al.

Summary: The study successfully prepared CS-GA hydrogels with excellent antioxidant properties and confirmed their ability to form cross-linked hydrogels under physiological conditions, as well as their potential applications in wound healing and hemostasis.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Pharmacology & Pharmacy

Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy

Ning Guo et al.

Summary: The study developed a novel aerogel dressing with enhanced solubility of photosensitizers for antibacterial photodynamic wound care. The aerogel showed excellent hemostasis capacity and antibacterial ability against Staphylococcus aureus, making it a promising candidate for clinical trials.

DRUG DELIVERY (2022)

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Article Dermatology

A collagen-based bi-layered composite dressing for accelerated wound healing

Leilei Sun et al.

Summary: The aim of this study was to develop collagen-based composite dressings for wound healing and investigate their mechanisms. The results showed that the non-crosslinked collagen-based bi-layered composite dressing stimulated wound healing, reduced inflammation, upregulated growth factors, and promoted collagen synthesis and fibroblast proliferation. This study provided theoretical support for the potential application of collagen-based composite dressings in wound healing.

JOURNAL OF TISSUE VIABILITY (2022)

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Article Engineering, Environmental

Hydrogel microreactor integrated double cascade reactions for synergistic bacterial inactivation and wound disinfection

Yuhao Weng et al.

Summary: This study developed a hydrogel microreactor GHAP that generates •OH and NO sequentially for synergistic bacterial inactivation, offering a promising solution to combat bacterial infections and antibiotic resistance.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Biochemistry & Molecular Biology

Antioxidant Silk Fibroin Composite Hydrogel for Rapid Healing of Diabetic Wound

Biswanath Maity et al.

Summary: In this study, a composite hydrogel for rapid wound healing in diabetic condition is developed, which releases berberine slowly and has the ability to control oxidative stress and promote wound repair.

MACROMOLECULAR BIOSCIENCE (2022)

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Article Engineering, Biomedical

Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing

Yong Wang et al.

Summary: A mussel-inspired bioactive scaffold consisting mainly of collagen and hyaluronic acid has been developed for the treatment of chronic diabetic wounds. The scaffold exhibits antioxidant and anti-inflammatory effects, promoting wound healing.

MATERIALS TODAY BIO (2022)

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Article Engineering, Environmental

Immuno-modulating theranostic gold nanocages for the treatment of rheumatoid arthritis in vivo

Rajiu Venkatesan et al.

Summary: This study developed a nanoplatform for targeted treatment of rheumatoid arthritis, demonstrating its anti-inflammatory and anti-arthritic effects in vitro and in vivo.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

In-situ forming hydrogel incorporated with reactive oxygen species responsive and antibacterial properties for diabetic infected chronic wound healing

Wang Chengwei et al.

Summary: In this study, an in-situ gelled and shape-adaptable hydrogel with antibacterial and ROS scavenging properties was developed for chronic diabetic wound healing. The hydrogel provided a physical barrier that protected the wounds from bacteria and promoted wound healing. It exhibited great biocompatibility, antibacterial activity, and the ability to adjust inflammation and promote collagen deposition for wound contraction and healing.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Materials Science, Biomaterials

Oxygenation therapies for improved wound healing: current trends and technologies

Ganma et al.

Summary: The degree of oxygenation is a crucial factor in wound healing, affecting various processes and ultimately determining the success of tissue recovery. This article provides an overview of the role of oxygen and the different oxygenation therapies used in healing dermal wounds. Additionally, it critically assesses the challenges and opportunities for delivering oxygen effectively and safely at the wound site.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Multidisciplinary

Photo-Controllable Catalysis and Chiral Monosaccharide Recognition Induced by Cyclodextrin Derivatives

Lei Chen et al.

Summary: A supramolecular catalytic system was constructed using polycationic alpha-cyclodextrin and gold nanoparticles through a supramolecular assembly strategy. The cavity of cyclodextrin acts as the channel for substrate molecules to interact with the catalytic center. The introduction of azobenzene-modified diphenylalanine guest molecules allows for precise photo-control of catalytic activity and enables chiral recognition catalysis for chiral monosaccharides.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Environmental

Injectable dry cryogels with excellent blood-sucking expansion and blood clotting to cease hemorrhage for lethal deep-wounds, coagulopathy and tissue regeneration

Xin Zhao et al.

Summary: This study designed a series of antioxidant, photo-thermal, and antibacterial expandable dry cryogels based on polydopamine crosslinked chitosan, showing excellent biomedical properties for hemostasis and wound healing.

CHEMICAL ENGINEERING JOURNAL (2021)

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Meeting Abstract Hematology

Intravenous Nanomedicine for Targeted Delivery of Thrombin to Augment Hemostasis

Anirban Sen Gupta et al.

BLOOD (2021)

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Article Engineering, Biomedical

Flexible electrical stimulation device with Chitosan-Vaseline® dressing accelerates wound healing in diabetes

Xiao-Feng Wang et al.

Summary: The study demonstrated that using chitosan-vaseline gauze combined with a flexible electrical stimulation device can promote diabetic wound healing, with high voltage monophasic pulsed current shown to be beneficial in vivo. In vitro experiments showed that high voltage monophasic pulsed current can enhance proliferation and migration of human umbilical vein endothelial cells.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Glucose-triggered in situ forming keratin hydrogel for the treatment of diabetic wounds

Yansong Chen et al.

Summary: The study developed a glucose-triggered in situ forming keratin hydrogel via higher oxidation force of hydrogen peroxide, which shortened gelation time and improved mechanical strength. This method required no additional crosslinking agents or chemical modifications on keratins and showed potential in treating diabetic wounds.

ACTA BIOMATERIALIA (2021)

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Article Nanoscience & Nanotechnology

Magnetically Guided Nanoworms for Precise Delivery to Enhance In Situ Production of Nitric Oxide to Combat Focal Bacterial Infection In Vivo

Bitao Lu et al.

Summary: The study presents an all-in-one hollow nanoworm with exceptional magnetic-targeting ability and photothermal therapeutic effect, which can be precisely delivered to infection sites for highly effective bacterial elimination. It offers a novel approach for eradicating abscesses in the body by combining magnetic guidance therapy and near-infrared-triggered in situ generation of NO gas.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion

Yang Yuan et al.

Summary: A novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond was designed for dynamic burn wounds, showing enhanced physicochemical properties and efficacy, suitable for wounds with irregular shapes.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Preparation and Fluorescent Wavelength Control of Multi-Color Nitrogen-Doped Carbon Nano-Dots

Wenli Li et al.

Summary: This study synthesized multi-color fluorescent materials with nitrogen-doped CNDs using a fast and effective microwave method, and investigated the influence of different raw material ratios on the structure and optical properties of N-CNDs. Results showed that the PL emission wavelength of N-CNDs can be tuned by controlling the N concentration, and the PL intensity is positively correlated with the content of C-O groups on the surface/edges of N-CNDs.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Reed Leaves Inspired Silica Nanofibrous Aerogels with Parallel-Arranged Vessels for Salt-Resistant Solar Desalination

Xiangyang Dong et al.

Summary: Biomimetic hierarchical nanofibrous aerogels inspired by plant leaves, RNFAs, solve salt crystallization and high concentration brine issues in solar desalination, with excellent mechanical properties and high evaporation rate.

ACS NANO (2021)

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Article Multidisciplinary Sciences

Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

Xinchen Du et al.

Summary: Researchers have developed an alkylated chitosan sponge with highly interconnective microchannels, demonstrating its advantages in anti-infective, pro-coagulant, hemostatic, and wound healing capacities, making it suitable for treating noncompressible hemorrhages.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

Luoxiao Ran et al.

Summary: The study developed a novel biomimetic nano-antibacterial system RBCM-NW-G, which controls the release of antibiotics through near infrared, showing good biocompatibility and long blood circulation time. In mouse experiments, the system effectively accumulated at the infection site, demonstrating damage to biofilms and efficient antibacterial performance.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary