期刊
JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY
卷 13, 期 4, 页码 307-317出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/jispcd.JISPCD_55_23
关键词
Gingival crevicular fluid; neurokinin A; painful teeth; substance P; symptomatic irreversible pulpits
This study evaluated the levels of neuropeptides neurokinin A (NKA) and substance P (SP) in patients with symptomatic irreversible pulpitis (SIP) using a systematic review and meta-analysis. The results showed that there was no significant association between NKA and SP levels in the gingival crevicular fluid (GCF) of individuals with SIP. This suggests that further research is needed in this area to better understand the relationship between pulpal disorders and NKA.
Aims and Objectives: The levels of neuropeptides neurokinin A (NKA) and substance P (SP) in the gingival crevicular fluid of patients with symptomatic irreversible pulpitis (SIP) were evaluated using a comprehensive review and meta-analysis.Materials and Methods: The data bases of Pubmed, Scopus, EBSCOhost, Science Direct, Proquest and Cochrane library databases were thoroughly searched. The quality of the study was evaluated using the Joanna Briggs Criteria. Twenty four studies were listed following a thorough search of full texts, abstracts, and removal of duplicates. Only two of these papers were eligible for inclusion in the meta-analysis. Since the results obtained were in mean and standard deviation, the levels of neuropeptides in the test and control groups were examined using the meta-analysis.Results: When compared with healthy teeth, NKA was not significantly elevated in GCF of individuals with SIP (P = 0.06; odd ratio = 1.34 [-0.05 to 2.74] at 95% confidence interval [CI]). Additionally, there was no evidence of an association between SP and SIP (P = 0.08; odds ratio = 0.84 [-0.10 to 1.77] at 95% CI).Conclusion: This systematic research demonstrated that in individuals with SIP, NKA, and SP are not substantially linked. However, the lack of study in this area makes it evident that additional research is needed, particularly in relation to pulpal disorders and NKA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据