☆ 4.6 Review

Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy

JOURNAL OF MATERIALS CHEMISTRY B (2023)

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Article Cell Biology

Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood-Brain Barrier Model and Entry to Human Brain Organoids

Maria Meszaros et al.

Summary: Research has found that nanoparticles targeting cerebral endothelial cells can enhance drug delivery to the brain. By combining alanine and glutathione, these polypeptide nanocarriers showed increased permeability and cellular uptake in a co-culture model of human endothelial cells and brain pericytes. These findings suggest that poly(l-glutamic acid) nanoparticles can be effective nanocarriers for drug delivery to the nervous system.

CELLS (2023)

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Article Clinical Neurology

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Yun-Yun Hu et al.

Frontiers in Neurology (2023)

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Article Biotechnology & Applied Microbiology

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Clement Danis et al.

Summary: The study demonstrates the effectiveness of VHH Z70 in inhibiting Tau aggregation and reducing pathological Tau accumulation in brain neurons. By specifically targeting Tau within cells, VHH Z70 provides an immunological tool for targeting the intra-cellular compartment in tauopathies.

MOLECULAR THERAPY (2022)

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Article Engineering, Biomedical

Wireless Force-Inducing Neuronal Stimulation Mediated by High Magnetic Moment Microdiscs

Claudia Collier et al.

Summary: This study presents a noninvasive technique for manipulating neural activity through magneto-mechanical stimulation using magnetic microdiscs. By inducing mechanical forces on primary neuronal circuits with low-intensity and low-frequency magnetic fields, specific mechanosensitive ion channels can be activated, leading to effective stimulation of hippocampal and cortical neurons.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Pharmacology & Pharmacy

New advances in brain-targeting nano-drug delivery systems for Alzheimer's disease

Qin Ouyang et al.

Summary: This review discusses the pathogenesis hypotheses of Alzheimer's disease, the challenges in drug delivery, and the strategies of brain targeting nano-drug delivery systems. It also provides insights into novel strategies for AD therapy, such as exosomes, virus-like particles, and cell membrane coating particles.

JOURNAL OF DRUG TARGETING (2022)

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Review Chemistry, Multidisciplinary

Surface Modification of Lipid-Based Nanoparticles

Yining Xu et al.

Summary: This review provides an overview of various methods for lipid nanoparticle grafting and critically examines the usefulness and impact of these modifications in overcoming biological barriers, while predicting future developments in this field.

ACS NANO (2022)

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Review Cell Biology

Toward noninvasive brain stimulation 2.0 in Alzheimer's disease

Arianna Menardi et al.

Summary: Noninvasive brain stimulation techniques have potential applications in the study of Alzheimer's Disease, including early diagnosis, disease tracking, and therapy. However, current approaches have limitations. This study reviews and discusses experimental applications that aim to improve the efficacy of future noninvasive brain stimulation techniques.

AGEING RESEARCH REVIEWS (2022)

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Review Medicine, Research & Experimental

Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives

Rubiya Khursheed et al.

Summary: The advancements in nanotechnology have led to extensive exploration of metallic nanoparticles for biomedical applications. These nanoparticles possess inert nature and nanoscale structures similar to biological molecules, and their characteristics can be altered by changing certain particle properties. They have found applications in targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, and modulation of multiple applications in biomedicine.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Endocrinology & Metabolism

Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic

Min Su Kang et al.

Summary: This study utilized in vivo longitudinal study design and a variety of biomarkers to evaluate the efficacy of a novel brain-penetrating anti-amyloid fusion protein treatment in a transgenic rat model of Alzheimer's disease. The treatment significantly reduced brain amyloid-beta levels and improved related biomarkers.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

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Article Biochemistry & Molecular Biology

Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System

Farzad Salehpour et al.

Summary: The glymphatic system plays a crucial role in clearing toxins and waste metabolites from the brain. Photobiomodulation (PBM) therapy has shown neurotherapeutic benefits on glymphatic drainage and clearance. PBM-mediated enhancement of lymphatic system function could be a promising strategy for treating brain diseases associated with cerebrospinal fluid outflow abnormality.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging

Ya-Ling Jiang et al.

Summary: This study reveals that extracellular vesicles released by young osteocytes have beneficial effects on improving cognitive impairment and the pathogenesis of Alzheimer's disease, while those released by aged osteocytes do not have this effect. These vesicles can be transported to the brain under physiological and pathological conditions. Proteomic analysis shows that compared to aged vesicles, young vesicles contain multiple protective factors of Alzheimer's disease pathway.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

A multi-target theranostic nano-composite against Alzheimer's disease fabricated by conjugating carbon dots and triple-functionalized human serum albumin

Wenjuan Wang et al.

Summary: This study developed a multifunctional theranostic nano-composite, HSA-BFP@CDs, for the diagnosis and treatment of Alzheimer's disease (AD). It demonstrated efficient detection of Aβ plaques and inhibition of Aβ aggregation, as well as scavenging of reactive oxygen species (ROS). The multifunctionality of HSA-BFP@CDs was further confirmed in an AD model, showing its potential for AD diagnosis and treatment.

ACTA BIOMATERIALIA (2022)

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Review Cell Biology

Deep brain stimulation of fornix for memory improvement in Alzheimer's disease: A critical review

Ruofan Li et al.

Summary: Memory is a fundamental ability for all living organisms, and improving memory has attracted much attention for its potential in treating neurodegenerative diseases like Alzheimer's. Fornix deep brain stimulation (DBS) has been shown to globally improve cognitive function in a subset of Alzheimer's patients in clinical trials, making it a potential target for neurosurgical intervention in memory impairment.

AGEING RESEARCH REVIEWS (2022)

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Article Pharmacology & Pharmacy

Nanoparticles-based anti-aging treatment of Alzheimer's disease

Jian-Jian Chu et al.

Summary: Age is the most significant risk factor for Alzheimer's disease (AD) and anti-aging therapeutics may provide an alternative treatment for AD. Treatments targeting senescent cells have shown improvements in AD symptoms and cerebral pathological changes. Nanoparticles are considered a promising approach for efficiently crossing the blood-brain barrier and reducing side effects while enhancing therapeutic effectiveness in treating AD.

DRUG DELIVERY (2022)

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Article Oncology

Benefits and limitations of nanomedicine treatment of brain cancers and age-dependent neurodegenerative disorders

Margarita E. Neganova et al.

Summary: Nanomedicine provides a promising approach to overcome the limitations in the treatment of brain cancers, such as the blood-brain barrier, tumor heterogeneity and invasiveness, and tissue inaccessibility. Nanocarriers loaded with therapeutic agents can penetrate the blood-brain barrier and target specific cancer cells, showing potential anti-cancer effects.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Chemistry, Multidisciplinary

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

Xu Shao et al.

Summary: This review comprehensively summarizes the advantages and disadvantages of nanomaterials in modulating amyloid aggregation and AD treatment. It discusses the design of various functional nanomaterials and analyzes strategies for improved properties in AD treatment. Furthermore, it explores the challenges faced by nanomaterials in AD-related amyloid aggregate modulation and proposes future prospects for nanomaterials.

NANOSCALE ADVANCES (2022)

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Article Clinical Neurology

Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease

Yurii V. Stepanov et al.

Summary: Research has found that 808nm near-infrared light can protect against neurodegenerative diseases by altering metabolic processes and increasing the level of anti-inflammatory microglia cells. The light exposure also inhibits the production of pro-inflammatory cytokines, activates phagocytosis, and prevents oxidative stress damage to neurons.

ALZHEIMERS RESEARCH & THERAPY (2022)

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Review Geriatrics & Gerontology

Nanomedicines in the Management of Alzheimer's Disease: Current View and Future Prospects

Hitesh Chopra et al.

Summary: This article introduces the application of nanotechnology in Alzheimer's disease, including research in both diagnostic and therapeutic aspects. Nanotechnology may provide a new treatment option and improve the quality of life for Alzheimer's disease patients.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition

Yuting Ruan et al.

Summary: This study developed a nanotheranostics platform and demonstrated its effectiveness in reducing beta-amyloid plaque burden and improving memory deficits in APP/PS1 transgenic mice. The nanomaterial allowed noninvasive detection by magnetic resonance imaging and quantification of plaque volumes based on three-dimensional analysis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Clinical Neurology

Magnetic- field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles

E. Zhang et al.

Summary: The in vitro study demonstrates wireless control of neural activity using magnetoelectric nanoparticles with a sub-25-msec temporal response. The study shows that magnetoelectric nanoparticles can wirelessly induce calcium transients in neural cells, synchronized with magnetic pulses. This research provides a new approach to modulate neural activity, which is important for future applications in neuroscience.

BRAIN STIMULATION (2022)

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Review Cell Biology

A review on exosomes application in clinical trials: perspective, questions, and challenges

Jafar Rezaie et al.

Summary: Exosomes, as significant mediators of cell-to-cell communication, have promising applications in the treatment of various diseases. They can be used as biomarkers, cell-free therapeutic agents, and drug delivery carriers. However, there are challenges to overcome in the clinical application of exosomes, and further research and standardization are needed.

CELL COMMUNICATION AND SIGNALING (2022)

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Review Geriatrics & Gerontology

Small-molecule drugs development for Alzheimer's disease

Weiwei Yao et al.

Summary: This review summarizes small-molecule drugs developed based on the pathogenesis of Alzheimer's disease (AD) and provides a deeper understanding of AD. It aims to assist scientists in finding new and better treatments to gradually conquer the problems associated with AD in the future.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Chemistry, Multidisciplinary

Chiral Nanoparticles Force Neural Stem Cell Differentiation to Alleviate Alzheimer's Disease

Baimei Shi et al.

Summary: The study demonstrates that chiral nanoparticles can effectively accelerate the differentiation of neural stem cells into neurons under near-infrared light, with L-type nanoparticles outperforming D-type nanoparticles. This is due to their higher endocytosis efficiency. Gene expression analysis reveals that circularly polarized light and chiral nanoparticles upregulate specific genes associated with mechanical force and cytoskeleton proteins, leading to accelerated cell differentiation. In vivo experiments show that successful differentiation alleviates symptoms in Alzheimer's disease mice. Moreover, the combination of NIR irradiation and L-type nanoparticles enhances the clearance of amyloid and hyperphosphorylated p-tau proteins.

ADVANCED SCIENCE (2022)

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Review Pharmacology & Pharmacy

Blood-Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

Maj Schneider Thomsen et al.

Summary: Liposomes and other nanoparticles can be used as good candidates for delivering biologics across brain endothelial cells. Antibodies targeting the transferrin receptor can enhance the uptake of nanoparticles by endothelial cells and facilitate transport across the blood-brain barrier. Reducing antibody density or using monovalent antibodies can increase the uptake of nanoparticles by brain endothelial cells and promote further transport across the blood-brain barrier.

PHARMACEUTICS (2022)

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Article Materials Science, Biomaterials

Aptamer conjugated polydopamine-coated gold nanoparticles as a dual-action nanoplatform targeting β-amyloid peptide for Alzheimer's disease therapy

Juan Qin et al.

Summary: This study designed a new dual-action nanoplatform composed of aptamer-conjugated polydopamine-coated gold nanoparticles, which can effectively clear amyloid beta (Aβ) aggregates in Alzheimer's disease (AD) and alleviate Aβ-triggered cytotoxicity.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Review Biochemistry & Molecular Biology

Biomarkers for Alzheimer's disease-preparing for a new era of disease-modifying therapies

Henrik Zetterberg et al.

Summary: Clinical trial results indicate that antibody-based removal of Aβ plaques may slow cognitive decline in symptomatic AD, highlighting the need to identify suitable biomarkers for treatment. Further research into copathologies is necessary to facilitate the development and implementation of novel drug candidates against AD.

MOLECULAR PSYCHIATRY (2021)

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Review Biochemical Research Methods

Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer's Disease

Jayanti Mishra et al.

Summary: The utilization of nanotechnology and carbon nanotubes as a drug delivery system shows great potential in ameliorating Alzheimer's disease by overcoming biological barriers and enhancing drug delivery efficiency. Extensive research is needed to further develop advanced commercial products based on carbon nanotubes for Alzheimer's treatment.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2021)

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Review Endocrinology & Metabolism

Benefits of exercise training on cerebrovascular and cognitive function in ageing

Edward S. Bliss et al.

Summary: This review examines the effects of aging on cerebrovascular, cognitive, and neuroanatomical adaptations, as well as the potential benefits of exercise training in adults aged 50 and older. The evidence suggests that exercise can improve cerebrovascular function, cognition, and neuroplasticity in this age group, particularly in areas of the brain associated with executive function and memory, regardless of their health status. However, further research is needed to determine the mechanisms involved.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Review Pharmacology & Pharmacy

Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential

Firda Juhairiyah et al.

Summary: The review summarizes the challenges of brain drug delivery due to the blood-brain barrier and the current strategies using liposome-based drug delivery. Findings suggest that liposomal formulations may provide interesting changes in BBB transport, but further mechanistic studies are needed to understand their application in humans.

AAPS JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Coassembled Chitosan-Hyaluronic Acid Nanoparticles as a Theranostic Agent Targeting Alzheimer's β-Amyloid

Wenjuan Wang et al.

Summary: The coassembled nanoparticles of chitosan and hyaluronic acid cross-linked with glutaraldehyde (CHG NPs) were found to be an effective theranostic agent for imaging and inhibiting A beta fibrillization in Alzheimer's disease. The CHG NPs exhibited high sensitivity and selectivity in detecting A beta oligomers, showing potential for diagnosis and treatment of AD. In addition to fluorescence imaging, CHG NPs also demonstrated the capability to regulate A beta aggregation, making them a promising tool for theranostics in AD.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Adaptive Control of Nanomotor Swarms for Magnetic-Field-Programmed Cancer Cell Destruction

Yajing Shen et al.

Summary: This study designs adaptive control behaviors of Cy5-tagged caspase-3-specific peptide-modified MNMs, inducing cancer cell apoptosis in lysosomes under the action of a rotating magnetic field. A predicted magneto-programmed vortex is observed around swarms under RMF using a finite element method model, with critical rotating frequency correlated to assembling and swarming properties. Real-time frequency-adapted controllability of MNM swarms for cancer cell apoptosis is demonstrated both in vitro and in vivo.

ACS NANO (2021)

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Review Cell & Tissue Engineering

Multipotent stromal cells One name, multiple : identities

Hesham Soliman et al.

Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.

CELL STEM CELL (2021)

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Article Chemistry, Multidisciplinary

Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome

Salwa et al.

Summary: This review provides detailed updates on the latest research progress of stem cell therapy as an adjunct treatment for Alzheimer's disease, discussing its challenges and potential, with a focus on recent advancements in regenerating neuronal circuitry in AD using stem cells.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Physical

Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals

Jung-uk Lee et al.

Summary: m-Torquer is a magnetic toolkit that mimics magnetoreception in nature, providing precise stimulation to cells and reliable neuromodulation in animals like mice. Its versatility allows for a wide range of applications, potentially even in large animals such as primates.

NATURE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Biomaterials in treatment of Alzheimer's disease

Mukta Agrawal et al.

Summary: Researchers are exploring the use of various biomaterials to develop drug carriers targeted at the brain, as well as biosensors and other diagnostic tools for early and precise Alzheimer's disease diagnosis. This approach aims to overcome the limitations of current treatment and diagnostic strategies, such as poor drug efficacy and lack of effective therapy, by utilizing the unique properties of biomaterials to improve drug delivery to the brain and enhance diagnostic capabilities.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Chemistry, Multidisciplinary

Controlled Synthesis and Surface Engineering of Janus Chitosan-Gold Nanoparticles for Photoacoustic Imaging-Guided Synergistic Gene/Photothermal Therapy

Xiaoguang Dai et al.

Summary: The study developed a series of symmetrical and unsymmetrical chitosan/gold nanoparticles, utilizing the active motion derived from Janus structure, selective surface functionalization of polysaccharide domain, and photothermal effect of gold nanorods to construct Janus-structured chitosan/gold nanohybrids for breast cancer treatment. Investigating the morphology effect of chitosan/gold nanostructures on enhanced PTT, cellular uptake, and gene transfection, as well as exploring the feasibility of PA imaging to track the accumulation of J-ACP and guide PTT.

SMALL (2021)

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Article Geriatrics & Gerontology

Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model

Mei-Hong Lu et al.

Summary: The study demonstrated that intranasal delivery of human neural stem cells showed positive effects in Alzheimer's disease by improving pathological damages and rescuing cognitive function in transgenic mice.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Chemistry, Multidisciplinary

Magneto-Electrically Enhanced Intracellular Catalysis of FePt-FeC Heterostructures for Chemodynamic Therapy

Huilin Zhang et al.

Summary: An efficient intracellular catalysis method utilizing magneto-electronic approach is developed to induce eddy currents of FePt-FeC heterostructures in mild alternating magnetic fields. The induced catalytic reaction in the heterostructures significantly reduces the concentration of a crucial coenzyme in cancer cells under alternating magnetic stimulation, leading to the generation of senescent cancer cells for further treatment. This approach may enable precise catalytic tumor treatment by promoting intracellular catalytic reactions in tumors.

ADVANCED MATERIALS (2021)

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Review Neurosciences

The role of pathological tau in synaptic dysfunction in Alzheimer's diseases

Moxin Wu et al.

Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, with synaptic dysfunction recognized as the main cause of cognitive impairments. Pathological tau is suggested to induce synaptic dysfunction in various ways, contributing to cognitive decline in AD. Exploring the mechanism by which pathological tau impairs synaptic function is crucial for developing novel therapeutic strategies for AD.

TRANSLATIONAL NEURODEGENERATION (2021)

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Review Pharmacology & Pharmacy

Application of Antibody Fragments Against Aβ With Emphasis on Combined Application With Nanoparticles in Alzheimer's Disease

Zhi-Ting Sun et al.

Summary: Alzheimer's disease is a common neurodegenerative disease with amyloid-beta peptide playing a key role in its pathogenesis. While monoclonal antibody studies face challenges, antibody fragments offer advantages and their combination with nanoparticles can be used for the diagnosis and treatment of AD.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Urology & Nephrology

High-intensity Focused Ultrasound for the Treatment of Prostate Cancer: A National Cohort Study Focusing on the Development of Stricture and Fistulae

Amandeep Dosanjh et al.

Summary: This study examined the trend of HIFU treatment for prostate cancer in England and found that the number of HIFU procedures increased annually, with complication rates similar to established therapies.

EUROPEAN UROLOGY FOCUS (2021)

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Article Chemistry, Physical

Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles

Nicholas Andrikopoulos et al.

Summary: Amyloid aggregation is a common pathology underlying various human diseases, including Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Despite the challenges in treating these diseases, research has shown that synthesized nanoparticles can inhibit the aggregation of amyloid proteins and potentially offer therapeutic effects in animal experiments.

CHEMISTRY OF MATERIALS (2021)

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Article Agriculture, Multidisciplinary

PLGA-PEG Nanoparticles Facilitate In Vivo Anti-Alzheimer's Effects of Fucoxanthin, a Marine Carotenoid Derived from Edible Brown Algae

Mengxiang Yang et al.

Summary: Studies have shown that nanoscale PLGA-PEG-Fuc particles can improve the bioavailability of fucoxanthin, inhibit the formation of Aβ fibers and oligomers, reduce Aβ oligomer-induced neurotoxicity, and effectively prevent cognitive impairments in AD mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Neurosciences

Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model

Luodan Yang et al.

Summary: Studies have shown that photobiomodulation (PBM) can alleviate depressive and anxiety symptoms in early-stage Alzheimer's disease (AD) in rats, with positive effects on neuronal damage, neuroinflammation, and oxidative stress.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Review Endocrinology & Metabolism

Mesenchymal stem cell therapies for Alzheimer's disease: preclinical studies

Xiaorong Zhao et al.

Summary: Alzheimer's disease is a chronic, progressive neurodegenerative disorder characterized by memory failure, cognitive impairment, and behavioral manifestations. Cell therapy, particularly using mesenchymal stem cells (MSCs), is seen as a promising strategy for treating neurodegenerative disorders. MSCs have properties like replacement of damaged cells and paracrine effects, making them valuable in various disease aspects.

METABOLIC BRAIN DISEASE (2021)

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Article Acoustics

EFFECTS OF LOW-INTENSITY TRANSCRANIAL PULSED ULTRASOUND TREATMENT IN A MODEL OF ALZHEIMER'S DISEASE

Natalia dos Santos Tramontin et al.

Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by beta-amyloid plaques. New therapies are necessary for treating AD, with transcranial low-intensity pulsed ultrasound (LIPUS) showing potential as an adjuvant strategy for the late stage of the disease.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Optics

Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model

Lechan Tao et al.

Summary: Photobiomodulation using 1070-nm light can ameliorate cognitive and memory impairment in AD mouse model by reducing cerebral Aβ burden. The study demonstrates that 1070-nm light triggers microglia responses, leading to decreased Aβ load, and promotes angiogenesis to enhance Aβ clearance in AD mice. This research confirms the important roles of microglia and cerebral vessels in using 1070-nm light for the treatment of AD, and provides a framework for developing a novel therapeutic approach.

LIGHT-SCIENCE & APPLICATIONS (2021)

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Review Oncology

Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery

T. A. Arsiwala et al.

Summary: The blood-brain barrier (BBB) serves as a major barrier limiting drug passage into the brain, while the blood-tumor barrier (BTB) forms around tumors and remains effective in preventing chemotherapy delivery. Focused ultrasound is a noninvasive technique that can disrupt the BBB transiently, aiding in increased drug accumulation within targeted brain areas.

NEOPLASIA (2021)

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Article Neurosciences

Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease

Yangyang Lin et al.

Summary: The study investigated the effects of high frequency rTMS treatment on cognitive functions and pathological changes in the brains of 4- to 5-month old 5xFAD mice, showing positive impacts on preventing memory decline and increasing drainage efficiency of brain clearance pathways.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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Review Biotechnology & Applied Microbiology

Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Pooria Nakhaei et al.

Summary: Liposomes are a type of nanoparticles with a phospholipid membrane, rich in lipid contents, where cholesterol plays a vital role in stability. Despite various applications of liposomes, stability limitations still exist due to ingredient influence.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits

Yi-An Chen et al.

Summary: The study evaluated the therapeutic performance of MSC-exosomes in AD, showing that they could reduce Aβ expression, restore the expression of neuronal memory/synaptic plasticity-related genes, improve brain glucose metabolism and cognitive function in AD transgenic mice.

BIOMEDICINES (2021)

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Article Developmental Biology

Mechanosensitive ion channels in cell migration

Brenda Canales Coutino et al.

Summary: This review discusses the role of mechanosensitive ion channels in cell migration, focusing on the processes regulated by Ca2+. While some mechanosensitive channels are known to be involved in regulating cell migration, a unified analysis of the molecular mechanisms downstream of their activation is still lacking.

CELLS & DEVELOPMENT (2021)

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Article Clinical Neurology

Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer's Disease in Mice by Modulating the miR-567/NEUROD2/PSD95 Axis

Yongfeng Pang et al.

Summary: The current study demonstrated that rTMS treatment in mice with induced MCI associated with AD could improve cognitive function, attenuate brain tissue destruction, and enhance NEUROD2 and PSD95 expressions by inhibiting miR-567. The findings suggest that rTMS has potential as a protective treatment for MCI in AD, with effects dependent on miR-567 modulation.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Review Nanoscience & Nanotechnology

Dendrimer Architectonics to Treat Cancer and Neurodegenerative Diseases with Implications in Theranostics and Personalized Medicine

Hariharan Moorthy et al.

Summary: Theranostics, integrating diagnostic and therapeutic functions in a single platform, allows for noninvasive detection and treatment while monitoring disease progression and therapeutic efficacy in conditions like cancer and Alzheimer's disease. Theranostic tools can function independently or with the assistance of carriers like liposomes, micelles, polymers, or dendrimers, offering multifunctional properties for simultaneous imaging and drug delivery.

ACS APPLIED BIO MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Microglia in Alzheimer's Disease: The Role of Stem Cell-Microglia Interaction in Brain Homeostasis

Saeid Bagheri-Mohammadi

Summary: Microglia, as resident cells of the brain, play a crucial role in regulating neural development and maintaining neuronal networks, and their activation is associated with pathologic events and changes in brain homeostasis. In conditions like Alzheimer's disease, the activation of microglia by amyloid-beta deposition can lead to inflammatory responses, but stem cell therapy shows potential therapeutic effects in preventing the pathology..stem cells not only have the regenerative capacity for damaged neurons, but also possess immune-regulatory features that can modulate microglial activity and neuroinflammation, offering a potential remedial treatment for Alzheimer's disease.

NEUROCHEMICAL RESEARCH (2021)

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Article Clinical Neurology

Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019

David S. Knopman et al.

Summary: Aducanumab recently underwent two large phase III clinical trials that were stopped prematurely by the sponsor due to divergent outcomes. One trial showed potential benefits from high doses of Aducanumab, while the other did not show any benefits. Further analysis is needed to determine the true efficacy as a treatment for Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2021)

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Review Biochemistry & Molecular Biology

Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies

Jakub Sinsky et al.

Summary: Tau protein is crucial for the normal function of neurons and the brain by regulating microtubules, but in diseased conditions, pathological modifications can lead to aggregation and formation of harmful structures like PHFs and NFTs, causing neuronal loss and death.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Geriatrics & Gerontology

A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease

Ying-hui Chou et al.

NEUROBIOLOGY OF AGING (2020)

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Article Clinical Neurology

Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity

Xuemei Zong et al.

TRANSLATIONAL STROKE RESEARCH (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies

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Repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: clinical experience

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Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease

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BRAIN STIMULATION (2015)

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Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197): In Vivo Experiments

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The promise of stem cells in the therapy of Alzheimer's disease

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Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia

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Effects of Hydroxylated Carbon Nanotubes on the Aggregation of Aβ16-22 Peptides: A Combined Simulation and Experimental Study

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Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

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Multifunctional Liposomes Reduce Brain β-Amyloid Burden and Ameliorate Memory Impairment in Alzheimer's Disease Mouse Models

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The A beta peptide forms non-amyloid fibrils in the presence of carbon nanotubes

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Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging

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Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis

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Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity

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Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

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Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment

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Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology

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Symptomatic Treatment of Memory Decline in Alzheimer's Disease by Deep Brain Stimulation: A Feasibility Study

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Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

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Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

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Deep Brain Stimulation for Parkinson Disease An Expert Consensus and Review of Key Issues

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Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

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Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery

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Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB)

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Improved language performance in Alzheimer disease following brain stimulation

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A Phase I Trial of Deep Brain Stimulation of Memory Circuits in Alzheimer's Disease

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Understanding wiring and volume transmission

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Remote control of ion channels and neurons through magnetic-field heating of nanoparticles

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β-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

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Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation

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Review Clinical Neurology

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Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

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Embryonic stem cell-derived neural precursor cells improve memory dysfunction in Aβ(1-40) injured rats

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Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration

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Nanobodies as novel agents for cancer therapy

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Memantine in moderate-to-severe Alzheimer's disease

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