期刊
GENETICS
卷 204, 期 1, 页码 371-+出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.116.191148
关键词
Caenorhabditis elegans; QTL; shelterin; telomere length; whole-genome sequence
资金
- National Institutes of Health [GM-107227]
- Chicago Biomedical Consortium
- Chicago Community Trust
- American Cancer Society [127313-RSG-15-135-01-DD]
- Cell and Molecular Basis of Disease training grant [T32GM008061]
- National Science Foundation [DGE-1324585]
Telomeres are involved in the maintenance of chromosomes and the prevention of genome instability. Despite this central importance, significant variation in telomere length has been observed in a variety of organisms. The genetic determinants of telomere-length variation and their effects on organismal fitness are largely unexplored. Here, we describe natural variation in telomere length across the Caenorhabditis elegans species. We identify a large-effect variant that contributes to differences in telomere length. The variant alters the conserved oligonucleotide/oligosaccharide-binding fold of protection of telomeres 2 (POT-2), a homolog of a human telomere-capping shelterin complex subunit. Mutations within this domain likely reduce the ability of POT-2 to bind telomeric DNA, thereby increasing telomere length. We find that telomere-length variation does not correlate with offspring production or longevity in C. elegans wild isolates, suggesting that naturally long telomeres play a limited role in modifying fitness phenotypes in C. elegans.
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