Binding modes of high stoichiometry guest complexes with a Co8L12 cage uncovered by mass spectrometry

We demonstrate how different modes of guest binding with a Co8L12 cubic cage can be determined using ESI-MS. High stoichiometry guest binding was observed, with the guests preferentially binding externally, but internal guest inclusion was also seen at higher guest loading.

Automated summary

We show that ESI-MS can be used to determine the different modes of guest binding with a Co8L12 cubic cage. High stoichiometry guest binding was observed, with the guests predominantly binding externally, but internal guest inclusion was also observed at higher guest loading.