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Endoscopic-Directed Trans-Gastric Retrograde Cholangiopancreatography in Patients With Roux-en-Y gastric Bypasses

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JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 57, 期 9, 页码 871-878

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0000000000001864

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This meta-analysis aimed to evaluate the outcomes and safety of endoscopic ultrasound-directed trans-gastric retrograde cholangiopancreatography (EDGE) in patients with Roux-en-Y gastric bypass (RYGB). The results showed that EDGE had high technical and clinical success rates, but a relatively high adverse event rate, with LAMS dislodgement being the most common adverse event. The adverse event rate was significantly lower with 20-mm LAMS compared to 15-mm LAMS, suggesting the preference for the former.
Background and Aim:Endoscopic ultrasound-directed trans-gastric retrograde cholangiopancreatography (EDGE) is a new procedure for treating pancreaticobiliary diseases in patients with Roux-en-Y gastric bypass (RYGB). The aim of this meta-analysis was to determine the overall outcomes and safety of EDGE.Materials and Methods:We performed a computerized search of the main databases, including PubMed, EMBASE, Cochrane Library, and Science Citation Index, through October 2022. The main outcome measures examined in the meta-analysis were technical and clinical success rates and overall adverse event (AE) rate, especially the lumen-apposing metal stent (LAMS) dislodgement rate. AE rates were assessed according to LAMS size (15 vs. 20 mm), number of stages (single vs. two) and access route (gastrogastric vs. jejuno-gastric).Results:Fourteen trials with a total of 574 patients who had undergone 585 EDGE procedures were included in this study. The cumulative technical and clinical success and AE rates were 98%, 94%, and 14%, respectively. The commonest AE was LAMS dislodgement (rate 4%). The overall AE rate was lower in the 20-mm LAMS than in the 15-mm LAMS group (odds ratio [OR]=5.79; 95% confidence interval [CI]: 2.35 to 14.29). There were no significant differences in AE rate between number of stages (OR=1.36; 95% CI: 0.51 to 3.64) or differing access routes (OR=1.03; 95% CI 0.48 to 2.22).Conclusion:We here provide evidence that EDGE for endoscopic retrograde cholangiopancreatography yields good treatment outcomes in patients with RYGBs. The AE rate is significantly lower with 20-mm versus 15-mm LAMS; thus, the former is likely preferable.

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