☆ 4.7 Review

Unraveling the potential of M13 phages in biomedicine: Advancing drug nanodelivery and gene therapy

ENVIRONMENTAL RESEARCH (2023)

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Engineered Living Bacteriophage-Enabled Self-Adjuvanting Hydrogel for Remodeling Tumor Microenvironment and Cancer Therapy

Xue Dong et al.

Summary: Due to the complexity and heterogeneity in the tumor microenvironment, the efficacy of breast cancer treatment has been significantly impeded. In this study, a bioactive gel system using an engineered M13 bacteriophage was established to remodel the tumor microenvironment, inducing immunogenic death of tumor cells and down-regulating IDO1 expression. This system constructed by natural living materials could reverse immunosuppression and significantly improve the anti-breast cancer response.

NANO LETTERS (2023)

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Article Chemistry, Analytical

Gold nanoparticles-decorated M13 phage SPR probe for dual detection of antigen biomarkers in serum

Jinxiu Hou et al.

Summary: Label-free SPR is rarely used for biomarker detection in real samples due to its low sensitivity. Here, a phage-based SPR (P-SPR) strategy for the detection of carcinoembryonic antigen (CEA) in undiluted serums is reported. The proposed P-SPR method demonstrated ultrasensitive detection of CEA within 10 min, with a detection limit of 0.83 fM. The strategy also allows for cross-validation of SPR results through naked-eye counting of the plaques generated by the P-SPR probes, enabling a reliable dual detection system. The P-SPR scheme shows excellent sensing performance for the detection of real samples at concentrations lower than the LOD of ELISA.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Biochemistry & Molecular Biology

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

Aleksandra Petrovic Fabijan et al.

Summary: Phage therapy is a medical form of biological control using phages as antibacterial agents to combat bacterial infections. It is gaining renewed interest due to its potential in providing safe and effective cures for infections resistant to traditional antibiotics. However, further implementation and mainstream acceptance of phage therapy face challenges in biology, regulations, and economics.

PLOS BIOLOGY (2023)

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Review Biotechnology & Applied Microbiology

Current view on novel vaccine technologies to combat human infectious diseases

Zrinka Matic et al.

Summary: Research has shown that existing vaccines have their limitations, prompting the development of new vaccine technologies. In order to tackle new challenges, researchers are actively seeking safer, more efficient, and cost-effective platforms for vaccine development.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

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Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

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Review Chemistry, Multidisciplinary

T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity

Hui Yue et al.

Summary: T7 phage, with its unique advantages, can be genetically engineered to display foreign peptides or proteins on its capsid for specific targeting, making it promising in various biomedical applications such as imaging, therapeutics, drug and gene delivery, and detection tools.

ADVANCED SCIENCE (2022)

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Review Pharmacology & Pharmacy

Phages against Pathogenic Bacterial Biofilms and Biofilm-Based Infections: A Review

Siyu Liu et al.

Summary: Bacterial biofilms have high resistance to antimicrobial agents, posing a challenge in treating biofilm-based infections caused by drug-resistant bacteria. Bacteriophages, as natural enemies of bacteria, offer potential alternatives due to their specificity, safety, and non-toxicity.

PHARMACEUTICS (2022)

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Review Chemistry, Analytical

Advances in the Development of Phage-Based Probes for Detection of Bio-Species

Kameshpandian Paramasivam et al.

Summary: This review provides an overview of the recent advances in phage-based probes for ultra-sensitive detection of various bio-species. It discusses the assembly of phages with metal nanoparticles to form an organic-inorganic hybrid probe and its unique plasmon resonance effect for visual detection. The review also highlights the editing technologies of phage genomes and discusses the potential scenarios for clinical application of phage-probe-based detection methods.

BIOSENSORS-BASEL (2022)

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Article Chemistry, Multidisciplinary

Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods

Huan Peng et al.

Summary: Infections caused by drug-resistant bacteria are difficult to treat, but a study found that engineered phage-nanomaterial conjugates can effectively treat infected wounds caused by Gram-negative pathogens in mice. The treatment rapidly reduced bacterial load and promoted wound healing, outperforming standard-of-care antibiotics. The phage-nanomaterial treatment also worked against a strain resistant to last-line antibiotics, with no detectable toxicity or systemic effects.

ACS NANO (2022)

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Review Medicine, Research & Experimental

Biological foundations of successful bacteriophage therapy

Carola Venturini et al.

Summary: Bacteriophages are selective viral predators of bacteria and can be used to treat bacterial infections. However, there are challenges to implementing phage therapy into medical practice, including a lack of clinical trial data and a need for a better understanding of bacterium-phage interactions.

EMBO MOLECULAR MEDICINE (2022)

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Article Chemistry, Multidisciplinary

Phage Particles of Controlled Length and Genome for In Vivo Targeted Glioblastoma Imaging and Therapeutic Delivery

Uyanga Tsedev et al.

Summary: M13 phage can be used as a diagnostic and therapeutic platform, targeting GBM22 glioblastoma tumors and enabling tumor detection through shortwave infrared imaging. They can also deliver transcriptionally active genes to glioma cells in vitro.

ACS NANO (2022)

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Article Engineering, Biomedical

Hybrid M13 bacteriophage-based vaccine platform for personalized cancer immunotherapy

Xue Dong et al.

Summary: The study demonstrates a bioactive vaccine platform using hybrid M13 phage and personal tumor antigens for efficient delivery of antigens and activation of immune response. The vaccine not only prevents tumor occurrence but also delays tumor growth, showing potential synergy with immune checkpoint blockade therapy.

BIOMATERIALS (2022)

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Article Oncology

HER2-Displaying M13 Bacteriophages induce Therapeutic Immunity against Breast Cancer

Junbiao Wang et al.

Summary: This study demonstrates that phage-based HER2 vaccines can delay the onset and progression of breast cancer and generate anti-HER2 antibodies, providing a new approach for the treatment of HER2-positive breast cancer.

CANCERS (2022)

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Article Dermatology

Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2)

A. Wollenberg et al.

Summary: Tralokinumab monotherapy was found to be superior to placebo at 16 weeks of treatment in two 52-week phase III trials, ECZTRA 1 and ECZTRA 2, and was well tolerated up to 52 weeks of treatment with sustained efficacy.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Review Immunology

Phages and their potential to modulate the microbiome and immunity

Sara Federici et al.

Summary: Bacteriophages, as potential treatments against antibiotic-resistant bacterial infections, have gained renewed interest in utilizing them as therapeutic vectors and modulators of the human microbiome, with advancements in understanding their mechanisms through next-generation sequencing. The narrow host range, antibacterial repertoire, and ease of manipulation of phages offer promising possibilities for targeted modulation of pathogenic, commensal, and pathobiont microbiome members for impacting mammalian physiology and immunity.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Naked-eye counting of pathogenic viruses by phage-gold nanobiomaterials as probes

H. Xu et al.

Summary: An ultrasensitive naked-eye counting strategy was developed for quantifying AIV using phage-GNP probes, with a sensitivity down to 50 PFU/mL and potential application for pathogenic viruses like SARS-CoV-2.

MATERIALS TODAY ADVANCES (2021)

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Article Chemistry, Analytical

Monoclonal Antibody-Based Biosensor for Point-of-Care Detection of Type III Secretion System Expressing Pathogens

Yaron Hillman et al.

Summary: The antibiotic resistance crisis is predicted to lead to 10 million deaths annually by 2050. To address this impending challenge, the development of novel and rapid diagnostic tools is urgently needed. Through the creation of the monoclonal antibody mAb-EspB-B7, effective and stable differentiation of pathogenic bacteria is possible, showing promise as a key component in future rapid diagnostic tools.

ANALYTICAL CHEMISTRY (2021)

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Futuristic Non-antibiotic Therapies to Combat Antibiotic Resistance: A Review

Manoj Kumar et al.

Summary: The increasing resistance to antibiotics in microorganisms is a global health concern, with antibiotic-resistant genes from the environmental resistome being transferred to human and veterinary pathogens. Developing strategies to prevent excessive exposure of pathogens to antibiotics is crucial to combat this challenge effectively.

FRONTIERS IN MICROBIOLOGY (2021)

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Bacteriophage - A Promising Alternative Measure for Bacterial Biofilm Control

Fengjuan Tian et al.

Summary: Bacterial biofilms pose a serious threat to human health, requiring new strategies for management. Bacteriophages, due to their unique activity on bacteria and non-threat to humans, are considered safe alternatives with great potential. There are intricate mechanisms of interaction between phages and biofilms.

INFECTION AND DRUG RESISTANCE (2021)

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Phage Display Technique as a Tool for Diagnosis and Antibody Selection for Coronaviruses

Taruna Anand et al.

Summary: Phage display is an important and effective molecular biology technique that has been widely used for screening vaccine candidates and developing diagnostic tools. This versatile technique has been modified over the years to target various pathogens, including coronaviruses such as SARS-CoV-2, motivating researchers to search for therapeutic candidates.

CURRENT MICROBIOLOGY (2021)

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Article Chemistry, Analytical

Rapid detection of bacterial pathogens in blood through engineered phages-beads and integrated Real-Time PCR into MicroChip

M. G. Rizzo et al.

Summary: The study developed a new method for rapid and sensitive detection of bacteria in blood using engineered M13 phages and PCR in a miniaturized silicon microchip, providing a fast and efficient diagnosis approach.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Multidisciplinary

Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy

Hanna J. Wagner et al.

Summary: The recent approvals and ongoing clinical trials have established adeno-associated virus (AAV) as the leading gene delivery vehicle in gene therapy. Pharmaceutical companies are investing in AAV to expand therapeutic options. The emerging field of synthetic-biologically engineered AAV vectors has great potential to shape future gene therapeutic approaches.

ADVANCED SCIENCE (2021)

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Article Cell Biology

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

Kathy N. Lam et al.

Summary: The study demonstrates the use of engineered bacteriophage M13 to deliver DNA to Escherichia coli in the mouse gastrointestinal tract, enabling strain-specific depletion and genomic deletions. Multiple mechanisms allow E. coli to escape targeting, providing a foundation for microbiome editing and suggesting potential for extension to other phage-bacterial pairs.

CELL REPORTS (2021)

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Review Biochemical Research Methods

Phages in vaccine design and immunity; mechanisms and mysteries

Christiaan R. de Vries et al.

Summary: The article reviews the immunology of phage vaccines and highlights gaps in knowledge. It discusses the basic biology of phages and their use in vaccines, the mechanisms of immunity against engineered phages and phage DNA, and emphasizes the lack of understanding of the immunogenicity of these preparations. Mechanistic insight into the immunology of phage vaccines is deemed crucial for further development and clinical utility of these technologies.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

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Article Materials Science, Multidisciplinary

Detection of a single circulating tumor cell using a genetically engineered antibody-like phage nanofiber probe

J. Hou et al.

Summary: The study introduces a novel phage-based detection strategy for single circulating tumor cells (CTCs) identification, combining specific antibodies and PCR technology for precise detection.

MATERIALS TODAY ADVANCES (2021)

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Review Biochemistry & Molecular Biology

Interactions of Bacteriophages with Animal and Human Organisms-Safety Issues in the Light of Phage Therapy

Magdalena Podlacha et al.

Summary: Bacteriophages are viruses that infect bacterial cells, but recent studies have shown that they can significantly influence the functions of tissues, organs, and systems of mammals, including humans. They have the ability to penetrate eukaryotic cells and affect multiple organ systems, including the immune system, respiratory system, central nervous system, and digestive system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Virology

The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies

Dan Liu et al.

Summary: Phage therapy has garnered renewed interest due to increasing rates of antibiotic resistant bacteria infections. Safety and toxicity data associated with phage therapy in animals and humans have been systematically reviewed from English language publications between 2008-2021. While some adverse events were found in relation to phage therapy, serious events were extremely rare, highlighting the need for structured safety and tolerability endpoints in the therapeutic use of phages. Comprehensive and standardized reporting of potential toxicities associated with phage therapy has generally been lacking in published literature.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Design of a multi-epitope vaccine against cervical cancer using immunoinformatics approaches

Samira Sanami et al.

Summary: This study aimed to design a therapeutic vaccine against cervical cancer using reverse vaccinology, selecting E6 and E7 oncoproteins from HPV16 as target antigens for epitope prediction and constructing a multi-epitope vaccine with appropriate adjuvants. The physicochemical properties, antigenicity, and allergenicity of the vaccine construct were evaluated, and further analyses including molecular docking, MD simulation, and in silico cloning were performed. Results suggested the proposed vaccine could be effective, but further in vitro and in vivo experiments are needed for validation.

SCIENTIFIC REPORTS (2021)

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Article Microbiology

Bacteriophages and the Immune System

Medeea Popescu et al.

Summary: Bacteriophages, viruses that infect bacteria, play a significant role in modulating immunity by influencing bacterial expression of phage-encoded proteins, directly impacting innate immunity and bacterial clearance, and inducing adaptive immunity. The microbiome can be viewed as an interconnected network of bacteria, bacteriophages, and human cells, and maintaining the stability of these interactions is crucial for immunologic and metabolic health. Imbalance in this tri-kingdom relationship, caused by exposure to external phages, microbial dysbiosis, or immune dysregulation, may contribute to disease.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Review Infectious Diseases

Bacteriophage Technology and Modern Medicine

Aa Haeruman Azam et al.

Summary: Phages, as antibacterial agents, have a long history of use but were abandoned in most countries after the discovery of antibiotics. The rise of antimicrobial-resistant bacteria globally has renewed interest in phage therapy as an alternative to combatting AMR bacteria. Advances in molecular biology and genetic engineering have accelerated the development of phage-related products with superior therapeutic potentials against bacterial infections, and phage-based technology now serves multiple purposes beyond antibacterial treatment in modern medicine.

ANTIBIOTICS-BASEL (2021)

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Review Biochemistry & Molecular Biology

A combination therapy of Phages and Antibiotics: Two is better than one

Xianghui Li et al.

Summary: The emergence of antibiotic resistance is a major challenge for global health, leading to an urgent need for alternative therapeutic strategies due to a shortage of antibiotic pipelines. Phage-antibiotic synergy (PAS) has emerged as a promising approach to combat antibiotic-resistant pathogens, by enhancing bacterial killing and reducing the development of antibiotic resistance through a combination of phages and antibiotics. Additionally, the genetic and molecular mechanisms of phage antibiotic synergy, as well as the potential of engineered phages in reducing bacterial pathogenicity, are addressed in this review.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, Research & Experimental

A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance

Peipei Jin et al.

Summary: This study demonstrated a novel strategy in engineering biomimetic phage-based nanoparticles with improved blood retention and anti-bacterial performance, potentially impacting phage therapy.

THERANOSTICS (2021)

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Phage therapy for severe bacterial infections: a narrative review

Aleksandra Petrovic Fabijan et al.

MEDICAL JOURNAL OF AUSTRALIA (2020)

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Non-lytic M13 phage-based highly sensitive impedimetric cytosensor for detection of coliforms

Mohammed Sedki et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Yahiya Y. Syed

DRUGS (2020)

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A. R. Mushegian

JOURNAL OF BACTERIOLOGY (2020)

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Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages

Huan Peng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut

Bryan B. Hsu et al.

MSYSTEMS (2020)

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Catrin Sohrabi et al.

NATURE REVIEWS CHEMISTRY (2020)

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How Phages Overcome the Challenges of Drug Resistant Bacteria in Clinical Infections

Majid Taati Moghadam et al.

INFECTION AND DRUG RESISTANCE (2020)

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LANCET INFECTIOUS DISEASES (2020)

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BMC BIOINFORMATICS (2019)

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Phage Display Libraries: From Binders to Targeted Drug Delivery and Human Therapeutics

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MOLECULAR BIOTECHNOLOGY (2019)

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Construction of a genetically modified T7Select phage system to express the antimicrobial peptide 1018

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COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2019)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Combinatorial Avidity Selection of Mosaic Landscape Phages Targeted at Breast Cancer Cells-An Alternative Mechanism of Directed Molecular Evolution

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Editorial: Reverse Vaccinology

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FRONTIERS IN IMMUNOLOGY (2019)

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Bacteriophages as Alternatives to Antibiotics in Clinical Care

Danitza Romero-Calle et al.

ANTIBIOTICS-BASEL (2019)

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One-step production of phage-silicon nanoparticles by PLAL as fluorescent nanoprobes for cell identification

Laura M. De Plano et al.

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Efficient Genome Engineering of a Virulent Klebsiella Bacteriophage Using CRISPR-Cas9

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JOURNAL OF VIROLOGY (2018)

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Bacteriophages as biorecognition elements in capacitive biosensors: Phage and host bacteria detection

Gizem Erturk et al.

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Phage-Based Applications in Synthetic Biology

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Cell-free TXTL synthesis of infectious bacteriophage T4 in a single test tube reaction

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Genetically Engineered Phages: a Review of Advances over the Last Decade

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Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial

Nick Thatcher et al.

LANCET ONCOLOGY (2015)

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Article Chemistry, Multidisciplinary

Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies

Russell J. Krom et al.

NANO LETTERS (2015)

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Article Chemistry, Multidisciplinary

Advancing the Drug Discovery and Development Process

K. C. Nicolaou

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Ophthalmology

Intravitreal ranibizumab for the treatment of fibrovascular pigment epithelial detachment in age-related macular degeneration

Yiannis Iordanous et al.

CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE (2014)

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Article Microbiology

Bacteriophage Vehicles for Phage Display: Biology, Mechanism, and Application

Walead Ebrahimizadeh et al.

CURRENT MICROBIOLOGY (2014)

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Review Pharmacology & Pharmacy

Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems

Babak Bakhshinejad et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

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Article Oncology

Paclitaxel-Loaded PEG-PE-Based Micellar Nanopreparations Targeted with Tumor-Specific Landscape Phage Fusion Protein Enhance Apoptosis and Efficiently Reduce Tumors

Tao Wang et al.

MOLECULAR CANCER THERAPEUTICS (2014)

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Article Nanoscience & Nanotechnology

Enhanced tumor delivery and antitumor activity in vivo of liposomal doxorubicin modified with MCF-7-specific phage fusion protein

Tao Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Article Biotechnology & Applied Microbiology

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Robert J. Citorik et al.

NATURE BIOTECHNOLOGY (2014)

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Review Biology

The contribution of vaccination to global health: past, present and future

Brian Greenwood

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

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Article Gastroenterology & Hepatology

Phage display creates innovative applications to combat hepatitis B virus

Wen Siang Tan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Review Immunology

A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

Xavier Wittebole et al.

VIRULENCE (2014)

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Article Immunology

Influenza vaccine: Development of a novel intranasal and subcutaneous recombinant adjuvant

R. Segura-Velazquez et al.

VACCINE (2013)

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Article Biochemical Research Methods

M13 Bacteriophage Display Framework That Allows Sortase-Mediated Modification of Surface-Accessible Phage Proteins

Gaelen T. Hess et al.

BIOCONJUGATE CHEMISTRY (2012)

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Article Engineering, Biomedical

Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection

Shanta Raj Bhattarai et al.

BIOMATERIALS (2012)

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Article Oncology

Pilot study of the effect of romiplostim on child health-related quality of life (HRQoL) and parental burden in immune thrombocytopenia (ITP)

Robert J. Klaassen et al.

PEDIATRIC BLOOD & CANCER (2012)

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Article Biochemistry & Molecular Biology

Phage Displayed HBV Core Antigen with Immunogenic Activity

Aylin Ozdemir Bahadir et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2011)

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Article Hematology

A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia

James B. Bussel et al.

BLOOD (2011)

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Review Dermatology

Ecallantide is a novel treatment for attacks of hereditary angioedema due to Cl inhibitor deficiency

Henriette Farkas et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2011)

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Article Biochemical Research Methods

Evaluation of humoral and cellular immune responses against HSV-1 using genetic immunization by filamentous phage particles: A comparative approach to conventional DNA vaccine

Hamidreza Hashemi et al.

JOURNAL OF VIROLOGICAL METHODS (2010)

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Review Medicine, Research & Experimental

Bacteriophage interactions with phagocytes and their potential significance in experimental therapy

Aneta Kurzepa et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2009)

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Article Microbiology

Genetically engineered phage harbouring the lethal catabolite gene activator protein gene with an inducer-independent promoter for biocontrol of Escherichia coli

Zahra Moradpour et al.

FEMS MICROBIOLOGY LETTERS (2009)

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Article Multidisciplinary Sciences

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

Timothy K. Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biotechnology & Applied Microbiology

Killing cancer cells by targeted drug-carrying phage nanomedicines

Hagit Bar et al.

BMC BIOTECHNOLOGY (2008)

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Article Immunology

Inexpensive anti-cysticercosis vaccine:: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis

Julio Morales et al.

VACCINE (2008)

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Article Oncology

FDA drug approval summary: Panitumumab (Vectibix (TM))

Ruthann M. Giusti et al.

ONCOLOGIST (2007)

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Article Immunology

Development of a phage displayed disulfide-stabilized Fv fragment vaccine against Vibrio anguillarum

YJ Xia et al.

VACCINE (2005)

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Article Virology

Expression of a Foot-and-mouth disease virus immunodominant epitope by a filamentous bacteriophage vector

YJ Kim et al.

ARCHIVES OF VIROLOGY (2004)

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Article Biochemical Research Methods

Direct fluorochrome labeling of phage display library clones for studying binding specificities: applications in flow cytometry and fluorescence microscopy

DL Jaye et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2004)

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Article Immunology

Recombinant bacteriophage-based multiepitope vaccine against Taenia solium pig cysticercosis

K Manoutcharian et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2004)

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Article Immunology

Expression of a 28-kilodalton glutathione S-transferase antigen of Schistosoma mansoni on the surface of filamentous phages and evaluation of its vaccine potential

KVN Rao et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2003)

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Article Microbiology

Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections

C Westwater et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)

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Peptide-targeted PEG-liposomes in anti-angiogenic therapy

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)

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Article Oncology

Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine P815 model

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INTERNATIONAL JOURNAL OF CANCER (2002)

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Article Immunology

Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine

Y Wan et al.

VACCINE (2001)

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