☆ 4.7 Review

Review of traditional uses, phytochemistry and pharmacology of Tibetan Medicine tangchong

JOURNAL OF ETHNOPHARMACOLOGY (2024)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Plant Sciences

Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies

Bilqis Abiola Lawal et al.

Summary: This study found that the methanolic extract of Datura metel has potential therapeutic effects for Parkinson's disease, improving motor coordination and reducing muscle rigidity. The mechanism of action may be through multi-target inhibition of several key targets.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

添加到收藏夹

Article Chemistry, Organic

Concise Enantioselective Total Synthesis of Isopavine Alkaloids

Liu-Yang Pu et al.

Summary: In this study, we describe a concise and enantioselective total synthesis of isopavine alkaloids with a unique azabicyclo[3.2.2]nonane tetracyclic skeleton. Key steps include iridium-catalyzed asymmetric hydrogenation, Curtius rearrangement, and Eschweiler-Clarke methylation, enabling the synthesis of isopavine alkaloids in 6-7 linear steps. Additionally, we discovered that isopavine alkaloids, particularly (-)-reframidine (3), exhibit significant antiproliferative effects on various cancer cell lines for the first time.

JOURNAL OF ORGANIC CHEMISTRY (2023)

添加到收藏夹

Article Food Science & Technology

Occurrence and Chemistry of Tropane Alkaloids in Foods, with a Focus on Sample Analysis Methods: A Review on Recent Trends and Technological Advances

Lorena Gonzalez-Gomez et al.

Summary: This review collects available data on the occurrence of Tropane alkaloids (TAs) in foods and provides the latest techniques for food sample preparation from 2015 to present. Cereals and related products, as well as teas and herbal teas, are the most extensively analyzed food categories. Solid-liquid extraction remains the most widely used technique for sample preparation, but other extraction and purification techniques are also being applied.

FOODS (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Efficacy and safety of scopolamine compared to placebo in individuals with bipolar disorder who are experiencing a depressive episode (SCOPE-BD): study protocol for a randomised double-blind placebo-controlled trial

Cerena Miravalles et al.

Summary: This study aims to evaluate the antidepressant effects of intravenous scopolamine in individuals with bipolar disorder. Participants currently experiencing a depressive episode of at least moderate severity will receive three blinded infusions over a 2-week period and will be followed up to assess the treatment response and its contribution to the cholinergic hypothesis of mood disorders.

TRIALS (2022)

添加到收藏夹

Review Plant Sciences

Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants

Haiyue Gong et al.

Summary: In this review, we summarize the advances in the biosynthesis and engineering of MTA production, which holds great significance for the pharmaceutical industry.

FRONTIERS IN PLANT SCIENCE (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Advances in biosynthesis of scopoletin

Bo-Tao He et al.

Summary: This review summarizes the progress of scopoletin biosynthesis in artificial microbial cell factories. The two main pathways of scopoletin biosynthesis are summarized first, followed by the discussion of synthetic microbial cell factories as an attractive improvement strategy. The importance of emerging techniques in synthetic biology and metabolic engineering for efficient synthesis of scopoletin is also highlighted.

MICROBIAL CELL FACTORIES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis

Tian Tian et al.

Summary: The authors identify two polyketide synthases involved in cocaine biosynthesis and reveal the parallel evolution of these enzymes in tropane alkaloids-producing plants. The findings provide insight into the medicinal uses of tropane alkaloids such as hyoscyamine and cocaine. The study also elucidates the structural and biochemical basis for the recruitment of polyketide synthases in tropane alkaloid biosynthesis, expanding our understanding of biosynthetic catalysts.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development of Atropa belladonna L. Plants with High-Yield Hyoscyamine and without Its Derivatives Using the CRISPR/Cas9 System

Lingjiang Zeng et al.

Summary: In this study, A. belladonna plants without anisodamine and scopolamine were generated for the first time by CRISPR/Cas9-based disruption of hyoscyamine 6 beta-hydroxylase (AbH6H). These plants exhibited significantly elevated hyoscyamine production while lacking anisodamine and scopolamine, showing great potential for cost-effective production of hyoscyamine.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

New amides from the roots of Anisodus tanguticus

Hao-Yu Zhao et al.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2020)

添加到收藏夹

Article Chemistry, Analytical

Morphological, cytological and phytochemical studies in naturally occurring diploid and tetraploid populations of Physochlaina praealta from high altitudes of Trans-Himalaya

Younas Rasheed Tantray et al.

Summary: The study revealed that the concentration of phytoconstituents in Physochlaina praealta samples is positively correlated with the ploidy level and altitudinal gradients. Plants from higher elevations accumulated a significant amount of secondary metabolites, with different cytotypes showing differences in various morphometric characters due to polyploidy. Additionally, the methanolic extracts from leaves and stems of higher altitude plants showed the highest total phenol content.

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Kathrin Laura Kohnen-Johannsen et al.

MOLECULES (2019)

添加到收藏夹

Article Chemistry, Analytical

Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry

Nana Du et al.

JOURNAL OF SEPARATION SCIENCE (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine

Xiao Zheng et al.

DRUG DELIVERY (2018)

添加到收藏夹

Review Food Science & Technology

Atropa belladonna neurotoxicity: Implications to neurological disorders

Gunnar F. Kwakye et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bioactive halogenated dihydroisocoumarins produced by the endophytic fungus Lachnum palmae isolated from Przewalskia tangutica

Min Zhao et al.

PHYTOCHEMISTRY (2018)

添加到收藏夹

Article Agronomy

Larvicidal activity of synthetic tropane alkaloids against Ascia monuste orseis (Lepidoptera: Pieridae)

Simone Z. Mairink et al.

PEST MANAGEMENT SCIENCE (2017)

添加到收藏夹

Article Plant Sciences

Three new chlorinated phenolic glycosides from Przewalskia tangutica

Min Zhao et al.

PHYTOCHEMISTRY LETTERS (2017)

添加到收藏夹

Article Chemistry, Medicinal

Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro

Yan Zhang et al.

FITOTERAPIA (2016)

添加到收藏夹

Article Chemistry, Applied

Three new acyltyramines from Anisodus luridus Link et Otto (Solanaceae)

Lalit Kumar Lal Das et al.

NATURAL PRODUCT RESEARCH (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats

Fengjie Tian et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Effects of acetylsalicylic acid and UV-B on gene expression and tropane alkaloid biosynthesis in hairy root cultures of Anisodus luridus

Baifu Qin et al.

PLANT CELL TISSUE AND ORGAN CULTURE (2014)

添加到收藏夹

Article Plant Sciences

Amide Alkaloids from Scopolia tangutica

Zhen Long et al.

PLANTA MEDICA (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bishyoscyamine, one unusual dimeric tropane alkaloid from Anisodus acutangulus

Chang-An Geng et al.

CHINESE CHEMICAL LETTERS (2013)

添加到收藏夹

Article Chemistry, Medicinal

Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan

Sajeli Begum et al.

FITOTERAPIA (2010)

添加到收藏夹

Article Ophthalmology

TOXIC EFFECT OF SCOPOLAMINE EYE DROPS IN CHILDREN

B. HAMBORG-PETERSEN et al.

ACTA OPHTHALMOLOGICA (2009)

添加到收藏夹

Article Chemistry, Analytical

Determination of tropane alkaloid components in Przewalskia tangutica Maxim. by capillary electrophoresis with electrochemiluminescence detection

Ren Xiaona et al.

CHINESE JOURNAL OF CHROMATOGRAPHY (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

STEROIDAL SAPONINS FROM THE SEEDS OF HYOSCYAMUS NIGER L.

Irina Lunga et al.

CHEMISTRY JOURNAL OF MOLDOVA (2008)

添加到收藏夹

Article Chemistry, Medicinal

Scopolamine sublingual spray: An alternative route of delivery for the treatment of motion sickness

Abeer M. Al-Ghananeem et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2007)

添加到收藏夹

Article Chemistry, Medicinal

Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyoscyamus niger

B Sajeli et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ontogenetic variation of the tropane alkaloids in Datura stramonium

S Berkov et al.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2005)

添加到收藏夹

Article Plant Sciences

Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds

CY Ma et al.

JOURNAL OF NATURAL PRODUCTS (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.