The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta

Article Obstetrics & Gynecology

Association between placental implantation abnormalities and hypertensive disorders of pregnancy

Panchan Zheng et al.

Summary: This study found that complete PP is associated with a lower risk of PE, while PA is associated with a higher risk of GH-PE.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2022)

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Review Pharmacology & Pharmacy

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

Abdul Basit Baba et al.

Summary: The ubiquitously expressed cytokine transforming growth factor-beta (TGF-beta) plays a significant role in cellular mechanisms. It functions as a tumor suppressor at the early onset of malignancy but promotes tumorigenesis at an advanced stage. Moreover, TGF-beta regulates cell fate through immune and stroma components.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5

Bo Wang et al.

Summary: TAPT1 inhibits BMP signaling by destabilizing the SMAD1/5 protein, leading to its proteasomal degradation and thus affecting skeletal development.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

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Article Medical Laboratory Technology

Evaluation of Transforming Growth Factor-β1 and Interleukin-35 Serum Levels in Patients with Placenta Accreta

Tayyebe Khamoushi et al.

Summary: The serum levels of TGF-beta 1 and IL-35 were significantly elevated in patients with placenta accreta compared to healthy pregnant women, indicating a potential role in the pathogenesis of the disorder and suggesting them as potential targets for clinical and diagnostic approaches.

LABORATORY MEDICINE (2021)

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Article Obstetrics & Gynecology

Clinical profiles of placenta accreta spectrum: the PACCRETA population-based study

G. Kayem et al.

Summary: This study revealed that half of women with PAS do not have both placenta praevia and a prior caesarean delivery, and they have better maternal and neonatal outcomes.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

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Article Biochemistry & Molecular Biology

Activin A Promotes Osteoblastic Differentiation of Human Preosteoblasts through the ALK1-Smad1/5/9 Pathway

Hideki Sugii et al.

Summary: Activin A promotes osteoblastic differentiation of preosteoblasts through the ALK1-Smad1/5/9 pathway, potentially serving as a therapeutic product for healing alveolar bone and PDL tissue.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Anesthesiology

Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review

Alexander H. Oldman et al.

Summary: Higher FiO(2) may be associated with elevated oxidative stress during surgery, but limited studies have specifically reported biomarkers of oxidation. Further research in this area is urgently needed due to the current clinical controversy concerning perioperative oxygen therapy.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Biochemistry & Molecular Biology

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways

Isabelle Hernandez et al.

Summary: The study demonstrates the involvement of NADPH oxidase in the secretion of sFlt-1 and PlGF in first trimester chorionic villi, and indicates the participation of p38 MAPK pathway in sFlt-1 production and Nox activation. Additionally, the research highlights the major role of placental NADPH oxidase in mediating the signal transduction cascade of sFlt-1 production, as well as the involvement of p38 activation in first trimester placental Nox activity.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Ming-Li Zou et al.

Summary: Bone remodeling is a continuous process crucial for maintaining skeletal homeostasis, with Smad signaling pathway playing a key role in regulating osteoblast and osteoclast functions during this process. Targeting Smad signaling pathway could be a promising therapeutic strategy for treating osteoporosis.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Immunology

Role of Transforming Growth Factor-β1 in Regulating Fetal-Maternal Immune Tolerance in Normal and Pathological Pregnancy

Dongyong Yang et al.

Summary: TGF-beta 1 plays a crucial role in regulating fetal-maternal immune tolerance during pregnancy by inducing regulatory T cells and balancing macrophages, but dysregulation of TGF-beta 1 may be associated with recurrent spontaneous abortion and preeclampsia.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pathology

Possible Role of TGF-β1, MMP-2, E-CAD, β-Catenin and Antioxidants in Pathogenesis of Placenta Accreta

Maram El-Hussieny et al.

Summary: The study revealed significant increases in MMP-2 immunoexpression, GPx-1 mRNA, SOD, and GSH levels, along with decreases in immunoexpression of E-CAD and beta-catenin, as well as TGF-beta 1 mRNA in PA, indicating a potential role of loss of cell-cell adhesion and increased antioxidants in the pathogenesis of PA.

FETAL AND PEDIATRIC PATHOLOGY (2021)

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Article Endocrinology & Metabolism

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia

Jelena Brkic et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Urology & Nephrology

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

Elizabeth A. Phipps et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Review Medicine, Research & Experimental

The transforming growth factor β superfamily as possible biomarkers of preeclampsia: a comprehensive review

Enoch Appiah Adu-Gyamfi et al.

BIOMARKERS IN MEDICINE (2019)

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Review Obstetrics & Gynecology

Placenta accreta spectrum: pathophysiology and evidence-based anatomy for prenatal ultrasound imaging

Eric Jauniaux et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

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Editorial Material Obstetrics & Gynecology

Placenta accreta spectrum: a need for more research on its aetiopathogenesis

E. Jauniaux et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Placenta Accreta Spectrum: A Review of Pathology, Molecular Biology, and Biomarkers

Helena C. Bartels et al.

DISEASE MARKERS (2018)

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Editorial Material Obstetrics & Gynecology

FIGO consensus guidelines on placenta accreta spectrum disorders: Epidemiology

Eric Jauniaux et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2018)

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Review Immunology

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment

Juergen Pollheimer et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Developmental Biology

Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast

S. Haider et al.

PLACENTA (2017)

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Review Biotechnology & Applied Microbiology

Transforming growth factor-: A therapeutic target for cancer

Sulsal Haque et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Article Rheumatology

TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

Arjan van Caam et al.

ARTHRITIS RESEARCH & THERAPY (2017)

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Article Endocrinology & Metabolism

Aberrant TGFβ Signaling Contributes to Altered Trophoblast Differentiation in Preeclampsia

Jing Xu et al.

ENDOCRINOLOGY (2016)

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Article Cell Biology

TGF-β Signaling from Receptors to Smads

Akiko Hata et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

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Article Cell Biology

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

Jessica E. Davies et al.

CELL ADHESION & MIGRATION (2016)

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Article Developmental Biology

Reduced expression of the epidermal growth factor signaling system in preeclampsia

D. R. Armant et al.

PLACENTA (2015)

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Review Multidisciplinary Sciences

Polymorphisms and Plasma Level of Transforming Growth Factor-Beta 1 and Risk for Preeclampsia: A Systematic Review

Xun Li et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence

Chunxia Zhang et al.

NATURE COMMUNICATIONS (2014)

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Article Multidisciplinary Sciences

Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

S. Tsukamoto et al.

SCIENTIFIC REPORTS (2014)

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Article Endocrinology & Metabolism

Where Polarity Meets Fusion: Role of Par6 in Trophoblast Differentiation during Placental Development and Preeclampsia

Tharini Sivasubramaniyam et al.

ENDOCRINOLOGY (2013)

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Article Biochemistry & Molecular Biology

Transforming Growth Factor-β1 Inhibits Trophoblast Cell Invasion by Inducing Snail-mediated Down-regulation of Vascular Endothelial-cadherin Protein

Jung-Chien Cheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Oncology

Prevalence of infarct and villous clumps, and the expression of α-smooth muscle actin in the placental basal plate in severe preeclampsia

Min Kong et al.

MOLECULAR MEDICINE REPORTS (2013)

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Review Cell Biology

Regulating the stability of TGF beta receptors and Smads

Peter Lonn et al.

CELL RESEARCH (2009)

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Review Cell Biology

TGF-beta signaling in vascular biology and dysfunction

Marie-Jose Goumans et al.

CELL RESEARCH (2009)

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Review Physiology

Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis

Alice Wang et al.

PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-β signalling

SJ Wicks et al.

ONCOGENE (2005)

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Article Reproductive Biology

Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases

GE Lash et al.

BIOLOGY OF REPRODUCTION (2005)

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Article Peripheral Vascular Disease

Transforming growth factor-β1 (TGF-β1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation

M Muy-Rivera et al.

AMERICAN JOURNAL OF HYPERTENSION (2004)

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Article Urology & Nephrology

TGF-β induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

T Nakagawa et al.

KIDNEY INTERNATIONAL (2004)

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Article Endocrinology & Metabolism

Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia

K Koga et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

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Article Obstetrics & Gynecology

Transforming growth factor-beta 1 serum levels in pregnancy and pre-eclampsia

A Huber et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2002)

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The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta

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