期刊
FRONTIERS IN MICROBIOLOGY
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2016.01626
关键词
antimicrobial agents; food-producing animal; antimicrobial resistance; public health; molecular basis
类别
资金
- National Basic Research Program of China [2013CB127206]
- National Key Research and Development Program [2016YFD0501302]
- Fundamental Research Funds for the Central Universities [2662015PY035]
- Morning Program of Wuhan in China [2015070404010191]
- National Program for Risk Assessment of Quality and Safety of Livestock and Poultry Products [GJFP2016008]
- National Natural Science Foundation of China [31101856/31302143/31272614]
- National Key Technology RD Program [2012BAK01B00]
The risk of antimicrobial agents used in food-producing animals on public health associated with antimicrobial resistance continues to be a current topic of discussion as related to animal and human public health. In the present review, resistance monitoring data, and risk assessment results of some important antimicrobial agents were cited to elucidate the possible association of antimicrobial use in food animals and antimicrobial resistance in humans. From the selected examples, it was apparent from reviewing the published scientific literature that the ban on use of some antimicrobial agents (e.g., avoparcin, fluoroquinolone, tetracyclines) did not change drug resistance patterns and did not mitigate the intended goal of minimizing antimicrobial resistance. The use of some antimicrobial agents (e.g., virginiamycin, macrolides, and cephalosporins) in food animals may have an impact on the antimicrobial resistance in humans, but it was largely depended on the pattern of drug usage in different geographical regions. The epidemiological characteristics of resistant bacteria were closely related to molecular mechanisms involved in the development, fitness, and transmission of antimicrobial resistance.
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