☆ 4.5 Article

Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a randomized controlled pilot study

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cardiac & Cardiovascular Systems

Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health

Christian Heiss et al.

Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.

CARDIOVASCULAR RESEARCH (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Sex differences in microvascular function and arterial hemodynamics in nondialysis chronic kidney disease

Danielle L. Kirkman et al.

Summary: This study revealed potential sex differences in arterial hemodynamics and microvascular dysfunction in patients with CKD, with female patients showing poorer central hemodynamics and reduced microvascular function compared to males. The lower microvascular function observed in females may be contributed to by oxidative stress.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease

Trace Thome et al.

Summary: This study investigated the mechanisms of skeletal muscle mitochondrial impairment in mice with adenine-induced CKD. It found reductions in mitochondrial oxidative phosphorylation and identified unknown uremic metabolites associated with the degree of mitochondrial impairment. Additionally, CKD mice showed muscle atrophy, protein degradation, and morphological changes in the neuromuscular junction.

JCI INSIGHT (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Danielle L. Kirkman et al.

Summary: Cardiovascular disease is a leading cause of death in America, with advancing age being a major risk factor. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is associated with an increased CVD risk. Mitochondria play a crucial role in maintaining vascular homeostasis, and age- and disease-related impairments in mitochondrial function contribute to vascular dysfunction and increase CVD risk.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

添加到收藏夹

Article Rehabilitation

A randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations

Danielle L. Kirkman et al.

Summary: Aerobic exercise training can improve cardiopulmonary function in patients with chronic kidney disease, but does not have a significant impact on physical function and habitual physical activity levels.

ANNALS OF PHYSICAL AND REHABILITATION MEDICINE (2021)

添加到收藏夹

Review Physiology

Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Hasna Tirichen et al.

Summary: Mitochondrial reactive oxygen species (mtROS) and oxidative stress (OS) result in oxidative damage to cellular components such as lipids, DNA, and proteins, contributing to kidney damage and the progression of chronic kidney disease (CKD).

FRONTIERS IN PHYSIOLOGY (2021)

添加到收藏夹

Article Peripheral Vascular Disease

Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)

Yuting Li et al.

Summary: This study revealed a relationship between endothelial dysfunction and the higher prevalence of chronic kidney disease (CKD) in the general Japanese population. The findings indicate a positive correlation between endothelial function and the occurrence of CKD.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2021)

添加到收藏夹

Article Nutrition & Dietetics

Mitochondria-targeted antioxidant supplementation improves 8 km time trial performance in middle-aged trained male cyclists

S. C. Broome et al.

Summary: The study found that supplementation with MitoQ can improve cycling performance in middle-aged cyclists, including reducing completion time in an 8 km time trial and decreasing exercise-induced oxidative damage.

JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2021)

添加到收藏夹

Review Physiology

Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies

Danielle L. Kirkman et al.

Summary: Exertional fatigue is a common issue in patients with chronic kidney disease and end-stage renal disease, impacting their ability to perform daily activities. This review discusses the potential physiological contributors to exercise intolerance in kidney disease patients, highlighting the negative effects and potential interventions to address this symptom. Current and prospective lifestyle, pharmaceutical, and nutraceutical strategies are explored to improve exertional fatigue and quality of life in CKD and ESRD patients.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Acute mitochondrial antioxidant intake improves endothelial function, antioxidant enzyme activity, and exercise tolerance in patients with peripheral artery disease

Song-Young Park et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

添加到收藏夹

Article Urology & Nephrology

Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis

Jorge L. Gamboa et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

添加到收藏夹

Article Oncology

Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

Zachary S. Clayton et al.

JACC: CARDIOONCOLOGY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans

Dick H. J. Thijssen et al.

EUROPEAN HEART JOURNAL (2019)

添加到收藏夹

Article Physiology

Functional sympatholysis is impaired in end-stage renal disease

Justin D. Sprick et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2019)

添加到收藏夹

Article Physiology

Altered vascular function in chronic kidney disease: evidence from passive leg movement

Elissa K. Katulka et al.

PHYSIOLOGICAL REPORTS (2019)

添加到收藏夹

Article Physiology

Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial

Danielle L. Kirkman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation

Billie K. Alba et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

添加到收藏夹

Article Peripheral Vascular Disease

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

Matthew J. Rossman et al.

HYPERTENSION (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardiopulmonary exercise testing reveals subclinical abnormalities in chronic kidney disease

Danielle L. Kirkman et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2018)

添加到收藏夹

Article Physiology

Role of mitochondria-derived reactive oxygen species in microvascular dysfunction in chronic kidney disease

Danielle L. Kirkman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

添加到收藏夹

Review Physiology

Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging

W. Larry Kenney

JOURNAL OF APPLIED PHYSIOLOGY (2017)

添加到收藏夹

Review Urology & Nephrology

The hallmarks of mitochondrial dysfunction in chronic kidney disease

Daniel L. Galvan et al.

KIDNEY INTERNATIONAL (2017)

添加到收藏夹

Article Physiology

Endothelial dysfunction correlates with exaggerated exercise pressor response during whole body maximal exercise in chronic kidney disease

Ryan M. Downey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

添加到收藏夹

Review Physiology

The Vascular Endothelium in Chronic Kidney Disease: A Novel Target for Aerobic Exercise

Christopher R. Martens et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2016)

添加到收藏夹

Article Neurosciences

Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake

Daniel D. Shill et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

添加到收藏夹

Article Peripheral Vascular Disease

Arterial wave reflections and kidney function decline among persons with preserved estimated glomerular filtration rate: the Multi-Ethnic Study of Atherosclerosis

Jeffrey J. Hsu et al.

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

Keith G. Avin et al.

PLOS ONE (2016)

添加到收藏夹

Review Urology & Nephrology

Arterial stiffness and chronic kidney disease: lessons from the Chronic Renal Insufficiency Cohort study

Raymond R. Townsend

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2015)

添加到收藏夹

Article Sport Sciences

Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease

Erin J. Howden et al.

JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Arterial Stiffness, Central Pressures, and Incident Hospitalized Heart Failure in the Chronic Renal Insufficiency Cohort Study

Julio A. Chirinos et al.

CIRCULATION-HEART FAILURE (2014)

添加到收藏夹

Article Neurosciences

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

Rachel A. Gioscia-Ryan et al.

JOURNAL OF PHYSIOLOGY-LONDON (2014)

添加到收藏夹

Article Transplantation

Cardiac function and tolerance to ischemia-reperfusion injury in chronic kidney disease

James M. Kuczmarski et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2014)

添加到收藏夹

Article Physiology

NADPH oxidase-derived reactive oxygen species contribute to impaired cutaneous microvascular function in chronic kidney disease

Jennifer J. DuPont et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry

Ginger L. Milne et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

添加到收藏夹

Article Urology & Nephrology

Exertional Fatigue in Patients With CKD

Jamie H. Macdonald et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2012)

添加到收藏夹

Article Physiology

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin

Rebecca S. Bruning et al.

JOURNAL OF APPLIED PHYSIOLOGY (2012)

添加到收藏夹

Article Physiology

Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease

Jennifer J. DuPont et al.

JOURNAL OF APPLIED PHYSIOLOGY (2011)

添加到收藏夹

Article Peripheral Vascular Disease

Noninvasive Evaluation of Left Ventricular Afterload Part 1: Pressure and Flow Measurements and Basic Principles of Wave Conduction and Reflection

Julio A. Chirinos et al.

HYPERTENSION (2010)

添加到收藏夹

Article Gastroenterology & Hepatology

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

Edward J. Gane et al.

LIVER INTERNATIONAL (2010)

添加到收藏夹

Article Peripheral Vascular Disease

Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

Delyth Graham et al.

HYPERTENSION (2009)

添加到收藏夹

Article Pharmacology & Pharmacy

Mitochondrial effects of estrogen are mediated by estrogen receptor α in brain endothelial cells

Ali Razmara et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

添加到收藏夹

Article Urology & Nephrology

Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease

KE Sietsema et al.

KIDNEY INTERNATIONAL (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.