Photocatalytic C(sp2)-H sulfamoylation of enamides: regio- and stereoselective construction of (E)-β-sulfamoyl enamides

A photocatalytic regio- and stereoselective beta-C(sp(2))-H sulfamoylation of enamides was developed using commercially available sulfamoyl chlorides as the sulfamoyl radical sources. The reaction features mild and metal-free reaction conditions with a broad substrate scope and excellent functional group tolerance.

Automated summary

A photocatalytic method for the regio- and stereoselective beta-C(sp(2))-H sulfamoylation of enamides using commercially available sulfamoyl chlorides as sulfamoyl radical sources is developed. The reaction conditions are mild and metal-free with a broad substrate scope and excellent functional group tolerance.