期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 128, 期 -, 页码 419-426出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.02.040
关键词
Curcumin; Albumin PTX nanoparticle; Liposome; Synergism; Apoptosis
资金
- Basic Science Research Program of the National Research Foundation of Korea - Ministry of Education, Science and Technology [NRF 2014R1A1A2053373]
- Pioneer Research Center Program of the National Research Foundation of Korea - Ministry of Education, Science and Technology [NRF 2014M3C1A3054153]
- National Research Foundation of Korea [2014M3C1A3054153] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Paclitaxel (PTX) and curcumin (CUR) are potent chemotherapeutic agents used in the treatment of cancer. In the present study, hybrid polymer-lipid nanoparticles co-loaded with PTX and CUR were developed to investigate the therapeutic potential of a combination drug regimen. For this purpose, PTX-loaded albumin nanoparticles (APN) were prepared and encapsulated in PEGylated hybrid liposomes containing CUR (CL-APN) via a thin-film hydration technique. CL-APN was nanosized with a uniform spherical morphology. PTX and CUR release was sustained and occurred in a sequential manner, wherein CUR was expected to downregulate the nuclear factor NF-kappa B and Akt pathways and increase the therapeutic efficacy of PTX. The ratiometric combination of PTX and CUR was significantly more cytotoxic than the individual drugs. Importantly, dual-drug-loaded nanocarriers exhibited a superior cytotoxic effect than a cocktail combination at a lower dose. CL-APN induced significantly higher early and late apoptosis, induced a stronger G(2)/M arrest, and significantly increased the subG(1) cell population. By combining CUR, an effective NF-kappa B inhibitor, with PTX, a powerful anticancer drug, in a polymer-lipid hybrid nanoparticle system, we could improve the therapeutic efficacy in cancer treatments. Our results showed that such co-loaded delivery systems could serve as a promising therapeutic approach to improve clinical outcomes against various malignancies. (C) 2015 Elsevier B.V. All rights reserved.
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