期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 128, 期 -, 页码 498-505出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.02.049
关键词
Gold nanorods; Nanospheres; Photothermal effect; Drug release; 5-Fluorouracil
资金
- National Natural Science Foundation of China [21475071, 21405086, 21275082, 21203228]
- Natural Science Foundation of Shandong [ZR2014BQ001, BS2014YY009]
- National Key Basic Research Development Program of China [2012CB722705]
- Taishan Scholar Program of Shandong
- Natural Science Foundation of Qingdao [13-1-4-128-jch, 13-1-4-202-jch]
We described a facile synthesis of pH and near-infrared (NIR) light dual-sensitive core/shell hybrid nanospheres, consisting of gold nanorods (GNR) as the core and poly(N-isopropylacrylamide-co-methacrylic acid) as the shell, p(NIPAM-MAA). The resultant GNR/p(NIPAM-MAA) nanospheres showed a core/shell structure, with an average diameter of similar to 110 nm and a strong longitudinal surface plasmon band at NIR region. Due to the photothermal effect of GNR and pH/thermal-sensitive volume transition of p(NIPAM-MAA) hydrogels, the nanospheres with loading of 5-fluorouracil (5-FU) by electrostatic interactions were developed as a smart carrier for pH- and photothermal-induced release of 5-FU. Experimental results testified that the cumulative release of 5-FU from nanospheres was markedly increased in a mild acidic medium. Moreover, a NIR light (808 nm) irradiation triggered a greater and faster release of 5-FU, which was further testified by relevant results from in vitro cytotoxicity assay, in vivo tumor growth inhibition and histological images of ex vivo tumor sections. These results revealed significant applications of GNR/p(NIPAM-MAA) nanospheres in controlled release of anticancer agents and photothermal ablation therapy of tumor tissues, accompanied by synergistic effect of chem-photothermal therapy. (C) 2015 Elsevier B.V. All rights reserved.
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