期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 76, 期 10, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/lambio/ovad110
关键词
invasive pulmonary aspergillosis; galactomannan; bronchoalveolar lavage fluid; meta-analysis; lateral flow assay
This meta-analysis study found that lateral flow assay (LFA) using galactomannan in bronchoalveolar lavage fluid (BALF) exhibits high sensitivity and specificity for diagnosing invasive pulmonary aspergillosis (IPA).
The performance of lateral flow assay (LFA) in diagnosing invasive pulmonary aspergillosis (IPA) has not been well demonstrated. To address this, we conducted a meta-analysis assessing the overall accuracy of LFA in diagnosing IPA using bronchoalveolar lavage fluid (BALF). Over a systematical search and assessment of bias risk, we calculated the pooled specificity, sensitivity, and area under the receiver operating curve (AUC) to assess the diagnostic performance. Our meta-analysis included 11 studies. The combined total sensitivity and specificity for diagnosing IPA were 0.78 (95% confidence interval (CI): 0.71, 0.83) and 0.87 (95% CI: 0.81, 0.91), respectively. The AUC was 0.86 (95% CI: 0.82, 0.89). Our results demonstrate that LFA using galactomannan in BALF exhibits high sensitivity and specificity for diagnosing IPA.
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