期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 134, 期 -, 页码 469-474出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2015.07.028
关键词
Aligned porous fibers; Cell alignment; Cell adhesion; Anisotropic tissue engineering
资金
- National Natural Science Foundation of China [51273122, 51173120, 51202151]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [2013-693-11-6]
The potential applications of aligned, conductive electrospun fibers have been widely studied in anisotropic tissue regeneration. In this study, aligned porous poly L-lactic acid fibers were obtained with electrospinning, then polypyrrole nanoparticles (PPy NPs) were coated onto the porous fibers with oxidation polymerization to prepare electrically conductive fibers with about 1.24 mu m of diameter, and their surface conductivity was about 50 mS. The results of L929 cell test showed that more than 55% of cells grew along the aligned porous fiber axis, confirming that the cell guidance of aligned porous fibers was better than that of non-porous fibers. The results of differentiated PC12 cells on porous fibers showed that the alignment degree of neurite outgrowth and average neurite length of the cells were 84% and 111 mu m, respectively, which were larger than those on the non-porous fibers. A primary mechanism was proposed to explain effect of these pores on cell/neurite adhesion and orientation along the aligned porous fibers. (C) 2015 Elsevier B.V. All rights reserved.
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