期刊
ARCHIVES OF MEDICAL SCIENCE
卷 19, 期 5, 页码 1398-1409出版社
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms.2020.96617
关键词
systemic lupus erythematosus; lupus nephritis; glomerulonephritis; vascular diseases; podocytes; kidney tubules
There is a lack of information regarding tubular, interstitial, and vascular changes in the classification of lupus nephritis. This study emphasizes the importance of these less explored lesions and their role in the pathogenesis and prognosis of the disease.
A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for independent progression is known. This study reviewed the importance of less explored lesions by the current and widely used 2003 classification of lupus nephritis of the International Society of Nephrology/Renal Pathology Society (ISN/RPS), with emphasis on the tubulointerstitial, podocyte, and vascular lesions, increasingly recognised as being important in the pathogenesis and prognosis of the disease. Recognition of these lesions can help with therapeutic decision-making, thereby allowing better results for patients with systemic lupus erythematosus.
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