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NATURE REVIEWS CANCER
卷 23, 期 11, 页码 780-798出版社
NATURE PORTFOLIO
DOI: 10.1038/s41568-023-00615-0
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This article discusses the similarities and differences in the regulation and function of stem-like exhausted T cells and memory T cells, and explores their importance in cancer immunity.
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The latter encompass stem-like exhausted T cells and memory T cells, both of which have recently emerged as key determinants of cancer immunity and response to immunotherapy. Here, we discuss key similarities and differences in the regulation and function of stem-like exhausted CD8(+) T cells and memory CD8(+) T cells, and consider their context-specific contributions to protective immunity in diverse outcomes of cancer, including tumour escape, long-term control and eradication. Finally, we emphasize how recent advances in the understanding of the molecular regulation of stem-like exhausted T cells and memory T cells are being explored for clinical benefit in cancer immunotherapies such as checkpoint inhibition, adoptive cell therapy and vaccination.
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