Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa

Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.

Automated summary

Submerged cultivation results in the formation of new sulfur-containing sporothriolide derivatives, which show attenuated antimicrobial activity due to the presence of 2-hydroxy-3-mercaptopropanoic acid. However, these derivatives still exhibit moderate effects on the biofilms of Candida albicans and Staphylococcus aureus at lower concentrations.