期刊
FOOD BIOSCIENCE
卷 56, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fbio.2023.103158
关键词
Ketogenic diet; Biomarkers; Microbiota; Breast feeding; Rats
This study evaluated the effects of a ketogenic diet with high saturated fat content during lactation on biochemical outcomes and fecal bacterial groups in dams and offspring. The results showed that the diet increased fat deposition, impaired fecal microbial counts in dams, and induced adverse effects on lipid profile and fecal microbial counts in offspring.
A ketogenic diet (KD) is a dietary pattern characterized by high fat, moderate protein, and low carbohydrates. The present study evaluated the effects of a KD with saturated fat content during lactation on biochemical outcomes and selected fecal bacterial groups in dams and offspring. Wistar rat dams were assigned to the experimental groups (control or ketogenic), and pups from both dams received a standard chow diet from weaning until 60 days of age. KD consumption during lactation increased liver weight in dams, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol in pups and visceral and retroperitoneal fat in both dams and pups. Furthermore, KD increased Enterobacteriaceae and Bacteroides spp. While decreased Lactobacillus spp. and Bifidobacterium spp. counts in the feces of dams and pups. Results show that KD consumption during lactation increased fat deposition, impaired fecal microbial counts in dams, and induced short-and long-term adverse effects on lipid profile and fecal microbial counts in offspring. Findings indicate that consuming a KD with a high saturated fat content during lactation affects biochemical parameters and influences fecal bacteria associated with health in dams and pups.
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