期刊
FOOD & NUTRITION RESEARCH
卷 60, 期 -, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.3402/fnr.v60.30849
关键词
nutmeg oil; chronic pain; allodynia; COX-2; substance P
资金
- National Natural Science Foundation of China [8137384231400705]
- Natural Science Foundation of China Hubei [2013CFB451]
- Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province [2015ZD005]
Background: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Methods and Results: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. Conclusions: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据