期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 136, 期 -, 页码 562-569出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.09.057
关键词
Stimuli-responsive; pH-sensitive; Thermo-responsive; Drug delivery; Poly(amino acid)
资金
- NSFC [51203079]
- Natural Science Foundation of Tianjin [14JCYBJC18100]
- PCSIRT [IRT1257]
A pH- and thermo-responsive poly(amino acid)-based amphiphilic copolymer was developed, functioning as a tumour targeting drug delivery system with good biocompatibility and biodegradability. To provide multi-stimuli sensitivity characteristics to the poly(amino acid)s, the polyaspartamide scaffold has been functionalized with N,N-diisopropylamide groups via aminolysis reaction of polysuccinimide. PEG chains have also been chemically grafted to the poly(amino acid) backbone through acid-labile hydrazone linkages, providing a removable shield for the poly(amino acid) based nanoparticles. Furthermore, doxorubicin was chemically linked to the copolymer chain via hydrazone bonds, acting as the hydrophobic moiety to drive the polymeric self-assembly. Free doxorubicin molecules could be encapsulated into the self-assembled nanoparticles via hydrophobic interactions and molecular pi-pi stacking. The results obtained show that the drug release can be triggered by the temperature with a significantly increased release being observed under acidic conditions. The cytotoxicity behaviour of the copolymers and drug-loaded nanoparticles was investigated in vitro at varying pH values and different temperatures. In doing so, superior characteristics concerning compatibility and anti-cancer activity could be observed. (C) 2015 Elsevier B.V. All rights reserved.
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