4.4 Review

Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis

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Summary: This review summarizes recent advancements in the development of soluble biomarkers in osteoarthritis (OA), with a focus on soluble biomarkers and circulating non-coding RNAs. The study highlights the potential of cartilage acidic protein 1 (CRTAC1) as a promising biomarker for diagnosing and estimating the severity of hand, hip, and knee OA. Changes in the structure of glycosaminoglycans were found to discriminate OA from non-OA cartilage. Additionally, C-reactive protein metabolite (CRPM) and collagen metabolites may aid in distinguishing subsets of OA patients and tracking disease progression. Circulating microRNAs, lncRNAs, and circRNAs show promise in the diagnosis and prognosis of OA.

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GDF11 inhibits abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis

H. Wang et al.

Summary: Abnormal adipogenesis and decreased expression of GDF11 were observed in degenerative cartilage of TMJ OA. Supplementation of GDF11 effectively inhibits adipogenesis of chondrocytes and alleviates TMJ condylar cartilage degeneration. GDF11 may inhibit abnormal adipogenesis of chondrocytes by affecting the SUMOylation of PPAR gamma.

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Systemic induction of senescence in young mice after single heterochronic blood exchange

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Summary: Osteoarthritis is an age-related degenerative disease of the cartilage, and studies have shown that the increased number of senescent chondrocytes is associated with its development. Clearing senescent cells can improve osteoarthritis, while injection of these cells can induce the disease. The mechanisms and impact of senescence on osteoarthritis are still unclear. Immunotherapies may offer potential therapeutic methods to target senescence in osteoarthritis.

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Shabana Amanda Ali et al.

Summary: This study aims to identify circulating microRNAs that distinguish fast-progressing radiographic knee osteoarthritis (OA) by applying microRNA-sequencing. The miR-320 family is associated with fast-progressing knee OA and may serve as potential biomarkers and mechanistic drivers of the disease.

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Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Chong-Jie Wu et al.

Summary: This review mainly focuses on the role of senescent skeletal cells in initiating and progressing osteoarthritis, both independently and through cross-talk with macrophages/synovial cells. Current OA-targeted therapies based on eliminating senescent skeletal cells and inhibiting senescence-associated secretory phenotype (SASP) are summarized. The importance of existing animal models for studying OA from the perspective of senescence is highlighted, bridging the gap between basic research and clinical applications.

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MicroRNA-34a-5p Promotes Joint Destruction During Osteoarthritis

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Summary: The study highlights the role and therapeutic potential of miR-34a-5p in osteoarthritis, demonstrating elevated expression of miR-34a-5p in late-stage OA patients and in mouse OA models. The findings suggest that miR-34a-5p may play a critical role in OA pathogenesis and that modulation of its expression could have therapeutic benefits in OA treatment.

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Summary: Current research on cartilage markers focuses on structural components of the matrix, with a second generation of degradation markers developed against specific enzymes. High-throughput technologies allow detection of new markers and improved understanding of OA metabolic changes, enhancing patient selection and clinical trial evaluations.

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