Physical forces modulate interphase nuclear size

The eukaryotic nucleus exhibits remarkable plasticity in size, adjusting dynamically to changes in cellular conditions such as during development and differentiation, and across species. Traditionally, the supply of structural constituents to the nuclear envelope has been proposed as the principal determinant of nuclear size. However, recent experimental and theoretical analyses have provided an alternative perspective, which emphasizes the crucial role of physical forces such as osmotic pressure and chromatin repulsion forces in regulating nuclear size. These forces can be modulated by the molecular profiles that traverse the nuclear envelope and assemble in the macromolecular complex. This leads to a new paradigm wherein multiple nuclear macromolecules that are not limited to only the structural constituents of the nuclear envelope, are involved in the control of nuclear size and related functions.

Automated summary

The eukaryotic nucleus can change its size dynamically in response to cellular conditions. Supply of structural constituents and physical forces such as osmotic pressure and chromatin repulsion play crucial roles in regulating nuclear size. Multiple nuclear macromolecules beyond the structural constituents of the nuclear envelope are involved in controlling nuclear size and related functions.