Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway

Review Psychiatry

Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

Grace A. Porter et al.

Summary: This paper reviews two important risk factors for major depressive disorder, BDNF and inflammation, with a particular focus on the pathogenic implications of their interaction.

WORLD JOURNAL OF PSYCHIATRY (2022)

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Review Medicine, Research & Experimental

Tetramethylpyrazine: A review on its mechanisms and functions

Jianguo Lin et al.

Summary: Ligusticum chuanxiong Hort, also known as Chuanxiong in China, is a widely used medicinal herb with a long history. One of its active components, Tetramethylpyrazine (TMP), has shown to possess various pharmacological properties and has been used in the treatment of cardiovascular, nervous, and digestive system conditions, as well as cancer. TMP exerts its effects through multiple physiological functions and bidirectional regulation of multiple targets and signal pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Chemistry, Medicinal

Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders

Mei Zhang et al.

Summary: Neurological disorders, characterized by occult onset and progressive development, can cause serious damage to the human body during the aging process. Traditional medicine, such as Ziziphi Spinosae Semen (ZSS), has the potential to prevent and treat these diseases. ZSS, the seeds of Ziziphus jujuba var. spinosa, has demonstrated various neuroprotective activities, making it a popular natural product with medicinal and pharmacological importance.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

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Article Neurosciences

Long-Term Potentiation-Like Visual Synaptic Plasticity Is Negatively Associated With Self-Reported Symptoms of Depression and Stress in Healthy Adults

Trine Waage Rygvold et al.

Summary: Long-term potentiation (LTP) is extensively studied in relation to memory and learning. Accumulating evidence suggests that impaired synaptic plasticity plays a role in neuropsychiatric disorders. This study aims to replicate and confirm the use of visual stimulus-specific response modulation as a probe for LTP-like plasticity and explore its association with subclinical depressive symptoms and stress in healthy individuals. Results showed that reduced LTP-like plasticity is associated with higher levels of self-reported symptoms of depression and perceived stress, indicating its sensitivity to psychological distress and its potential as a vulnerability marker for depression.

FRONTIERS IN HUMAN NEUROSCIENCE (2022)

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Article Pharmacology & Pharmacy

Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomnia via activation of GABAA receptor

Fengqin Xiao et al.

Summary: This study obtained a Ziziphus jujuba var. spinosa extract (ZSSE) and analyzed its chemical constituents. Through in vivo experiments, the potential mechanism of ZSSE in improving sleep was revealed, showing that it regulated the levels of GABA, Glu, 5-HT, and DA and the expression of GABA receptors in specific brain areas. This research provides valuable insights into the pharmacological mechanism of ZSSE for sleep improvement.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

A review on the advances in the extraction methods and structure elucidation of Poria cocos polysaccharide and its pharmacological activities and drug carrier applications

Tianren Xu et al.

Summary: This review provides a comprehensive summary of the latest extraction and purification methods, chemistry, synthesis of PCP derivatives, pharmacological activities, and applications of PCP as drug carriers. PCP exhibits diverse biological functions and has potential for drug development.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

PCSK9 Induces Tissue Factor Expression by Activation of TLR4/NFkB Signaling

Valentina Scalise et al.

Summary: PCSK9 induces TF expression through activation of the TLR4/NFkB signaling pathway, with TF playing an essential role in both coagulation and inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Neurosciences

Psychological Stress as a Risk Factor for Accelerated Cellular Aging and Cognitive Decline: The Involvement of Microglia-Neuron Crosstalk

Micael Carrier et al.

Summary: Microglia play crucial roles in the central nervous system, with the potential to both protect and exacerbate neurodegeneration. Chronic stress accelerates cellular aging, leading to cognitive decline. Stress-induced neuroinflammation alters microglial interactions, exacerbating cellular damage and inducing cognitive aging.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway

Zuliang Jie et al.

Summary: Microglia play a critical role in the progression of EAE by mediating noncanonical NF-κB signaling pathway, with NIK being essential for the recruitment of inflammatory T cells and monocytes in the CNS. The activation of T cell-derived cytokines and chemokines is important for the second-wave of T cell recruitment and disease progression in EAE.

SCIENCE ADVANCES (2021)

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Article Clinical Neurology

Traditional Chinese Formula Xiaoyaosan Alleviates Depressive-Like Behavior in CUMS Mice by Regulating PEBP1-GPX4-Mediated Ferroptosis in the Hippocampus

Haiyan Jiao et al.

Summary: This study established a depression mouse model to explore the role of ferroptosis in depression pathogenesis and the effects of Xiaoyaosan on PEBP1-GPX4-mediated ferroptosis in the hippocampus. Xiaoyaosan and fluoxetine improved depressive behaviors in mice induced by CUMS, suggesting ferroptosis could be a new target for depression research. The findings implied that ferroptosis might contribute to the antidepressant mechanism of Xiaoyaosan.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Review Gastroenterology & Hepatology

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation

Janine S. Y. Tam et al.

Summary: TLR4 antagonists show potential for treating intestinal inflammation, but there is limited research on this approach, indicating a need for further study.

INDIAN JOURNAL OF GASTROENTEROLOGY (2021)

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Article Biochemistry & Molecular Biology

TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling

Dongqiang Yang et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Behavioral Sciences

Effect of Toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress

Ke Zhang et al.

BRAIN AND BEHAVIOR (2020)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Ha Thi Thu Do et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Environmental Sciences

Aerobic Exercise Inhibits CUMS-Depressed Mice Hippocampal Inflammatory Response via Activating Hippocampal miR-223/TLR4/MyD88-NF-κB Pathway

Honglin Qu et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Article Neurosciences

Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model

Eduardo H. Sanchez-Mendoza et al.

MOLECULAR NEUROBIOLOGY (2020)

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Article Pharmacology & Pharmacy

Effects of lithium on cytokine neuro-inflammatory mediators, Wnt/β-catenin signaling and microglial activation in the hippocampus of chronic mild stress-exposed rats

Mohamed Z. Habib et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Article Clinical Neurology

Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity

Feifei Ren et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

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Article Pharmacology & Pharmacy

Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus

Jing Yang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Neurosciences

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA)

Wen-Ning Zhao et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2019)

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Article Multidisciplinary Sciences

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

Rachel Eyre et al.

NATURE COMMUNICATIONS (2019)

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Review Cell Biology

Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics

Muhammad Haseeb et al.

CELLS (2019)

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Article Chemistry, Analytical

A systematic data screening strategy for comprehensive characterization of chemical components in Suan-Zao-Ren decoction and their metabolic profiles in the plasma and brain of rats using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry

Yiyang Du et al.

ANALYTICAL METHODS (2019)

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Article Neurosciences

Wnt proteins as modulators of synaptic plasticity

Faye McLeod et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

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Article Biochemical Research Methods

The investigation of immunoprotective and sedative hypnotic effect of total polysaccharide from Suanzaoren decoction by serum metabonomics approach

Xiaoyi Niu et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

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Review Neurosciences

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

Marion J. F. Levy et al.

PSYCHOPHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit

Wenping Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article

Role and Regulation of p65/β-Catenin Association During Liver Injury and Regeneration: A “Complex” Relationship

Kari Nejak-Bowen et al.

GENE EXPRESSION (2017)

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Article Chemistry, Analytical

Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches

Yiyang Du et al.

JOURNAL OF SEPARATION SCIENCE (2017)

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Review Neurosciences

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

Bangshan Liu et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

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Article Oncology

Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4/P-PAK1 cascade

Yongyu Chen et al.

ONCOTARGET (2017)

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Article Psychiatry

Recurrence of depressive disorders after interferon-induced depression

W-C Chiu et al.

TRANSLATIONAL PSYCHIATRY (2017)

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Review Neurosciences

Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications

Ather Muneer

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2017)

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Article Immunology

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

Yuyan Cheng et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Article Clinical Neurology

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

Yong-Ku Kim et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

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Article Oncology

Defective CFTR- β-catenin interaction promotes NF-κB nuclear translocation and intestinal inflammation in cystic fibrosis

Kaisheng Liu et al.

ONCOTARGET (2016)

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Article Neurosciences

Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons

Eduardo Perez-Palma et al.

NEURAL PLASTICITY (2016)

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Article Cell Biology

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/β-CATENIN signaling in rat hippocampus

Ana Maria Marques Orellana et al.

AGING-US (2015)

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Review Biochemistry & Molecular Biology

Neuronal correlates of depression

Dipesh Chaudhury et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Article Neurosciences

Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis

Annamaria Cattaneo et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

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Review Neurosciences

Neural Plasticity in Multiple Sclerosis: The Functional and Molecular Background

Dominika Justyna Ksiazek-Winiarek et al.

NEURAL PLASTICITY (2015)

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Article Neurosciences

Hippocampal Wnt3a is Necessary and Sufficient for Contextual Fear Memory Acquisition and Consolidation

Ning Xu et al.

CEREBRAL CORTEX (2015)

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Article Immunology

Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder

Szabolcs Keri et al.

BRAIN BEHAVIOR AND IMMUNITY (2014)

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Article Neurosciences

The Wnt Pathway in Mood Disorders

Gabriele Sani et al.

CURRENT NEUROPHARMACOLOGY (2012)

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Article Immunology

Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression

Iciar Garate et al.

JOURNAL OF NEUROINFLAMMATION (2011)

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Article Neurosciences

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

Francesca L'Episcopo et al.

MOLECULAR NEURODEGENERATION (2011)

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Article Plant Sciences

Hypnotic effect of jujubosides from Semen Ziziphi Spinosae

Jie-Xin Cao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2010)

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Article Multidisciplinary Sciences

Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

Santhakumar Manicassamy et al.

SCIENCE (2010)

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Review Medicine, General & Internal

Sertraline versus other antidepressive agents for depression

Andrea Cipriani et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2010)

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Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway

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