The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation

Article Neurosciences

Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis

Alireza Soltani Khaboushan et al.

Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.

MOLECULAR NEUROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Cattle Bile Arisaema Aqueous Extracts Protect Against Febrile Seizures in Rats Through Regulating Neurotransmitters and Suppressing Neuroinflammation

Fa-Zhi Su et al.

Summary: This study investigates the anti-convulsant effect and potential mechanism of cattle bile Arisaema (CBA) on febrile seizures. Results show that CBA can effectively lower the incidence rate and generation times of seizures, ameliorate neuronal damage, and regulate neurotransmitter disorder induced by febrile seizures.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Medicine, General & Internal

Anti-inflammatory and immune-mediated therapy for a case of febrile infection-related epilepsy syndrome with rapid recurrence

Tomonori Kurimoto et al.

Summary: Febrile infection-related epilepsy syndrome (FIRES) is a disease characterized by refractory frequent focal seizures, which require prolonged intensive care. A case study suggests that an autoimmune mechanism might be involved in the development of FIRES.

CLINICAL CASE REPORTS (2022)

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Article Multidisciplinary Sciences

Illumination of serotonin transporter mechanism and role of the allosteric site

Dongxue Yang et al.

Summary: This study used cryo-electron microscopy structures to elucidate the structural states of SERT in different conditions, revealing all fundamental steps of the transport cycle. The research identified the substrate-bound allosteric site and provided new structural insights into how SERT controls the binding and unbinding of serotonin.

SCIENCE ADVANCES (2021)

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Review Immunology

Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism

Heather M. Grifka-Walk et al.

Summary: Tryptophan is an essential amino acid involved in the synthesis of neurotransmitters and signaling molecules, regulating various physiological effects through the metabolism and production by both host cells and microbiome.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Neurosciences