☆ 4.7 Article

Total biosynthesis of fungal tetraketide pyrones

CHEMICAL COMMUNICATIONS (2023)

Biosynthesis of Terpenoid-Pyrrolobenzoxazine Hybrid Natural Product CJ-12662

Wei Cheng et al.

Summary: The fungal natural product CJ-12662, a terpene-amino acid hybrid, is a potent anthelmintic compound. The biosynthetic pathway of CJ-12662 involves successive P450-catalyzed oxidations of amorpha-4,11-diene for the terpene portion, and the transformation of esterified tryptophan into a chlorinated pyrrolobenzoxazine by three flavin-dependent enzymes through a cascaded [1,2]-Meisenheimer rearrangement.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Medicinal

Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908

Siwen Yuan et al.

Summary: The genome of Amphichorda felina SYSU-MS7908 contains 56 potential biosynthetic gene clusters (BGCs), suggesting that most of them may be silent. By heterologous expression, two new alpha-pyrone derivatives, amphichopyrone A and B, were discovered and shown to possess potent anti-inflammatory activity.

MARINE DRUGS (2022)

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Review Chemistry, Organic

Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Lukas Kahlert et al.

Summary: This article discusses the advantages, disadvantages, and future opportunities of total biosynthesis in fungi, focusing on several recent examples such as 2-pyridones, cytochalasans, and sorbicillinoids.

SYNTHESIS-STUTTGART (2021)

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Article Chemistry, Multidisciplinary