期刊
ELIFE
卷 5, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.14864
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资金
- National Cancer Institute [CA193419]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK107980]
- National Institute of General Medical Sciences [GM 114190, GM105847]
- National Institutes of Health [R01HG003143]
- National Science Foundation [1504942, DMR-1206868, MCB-1022117]
- Direct For Mathematical & Physical Scien
- Division Of Physics [1504942] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1206868] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1022117] Funding Source: National Science Foundation
The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can robustly compact, segregate and disentangle chromosomes, arriving at individualized chromatids with morphology observed in vivo. Our model resolves the paradox of topological simplification concomitant with chromosome 'condensation' , and explains how enzymes a few nanometers in size are able to control chromosome geometry and topology at micron length scales. We suggest that loop extrusion is a universal mechanism of genome folding that mediates functional interactions during interphase and compacts chromosomes during mitosis.
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