期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 153, 期 4, 页码 183-187出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2023.09.004
关键词
Itch; Dorsal horn; Glia
This study characterizes spinal microglial activation and its association with itch in a mouse model of psoriasis. The findings suggest that sensory neurons contribute to spinal microglial activation.
Although microglia are associated with chronic pain, the role of spinal microglia in the regulation of itch remains unclear. In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout the spinal cord after the topical application of IMQ. Furthermore, the mRNA expression of microglial markers and inflammatory mediators was upregulated. Ablation of itch-related sensory neurons using resin-iferatoxin decreased itch-related scratching behavior and the number of hypertrophic microglia in the spinal dorsal horn. Conclusively, sensory neuron input may partially contribute to spinal microglial activation after IMQ application.(c) 2023 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据