期刊
ELIFE
卷 5, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.08438
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资金
- European Research Council [207634]
- Medical Research Council [MC_UP_1202/3]
- Wellcome Trust [VVT098025MA]
- European Molecular Biology Organization [ALTF 1565-2010]
- National Science Foundation [OISE 1064530]
- Agencia National de Promotion Cientifica y Tecnologica [PICT 2012 1954, 2013 1301]
- Max-Planck-Gesellschaft
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Medical Research Council [MC_UP_1202/3] Funding Source: researchfish
- European Research Council (ERC) [207634] Funding Source: European Research Council (ERC)
- MRC [MC_UP_1202/3] Funding Source: UKRI
In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a segmentation clock. This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression patterns in the embryo. Whether individual cells autonomously maintain oscillations, or whether oscillations depend on signals from neighboring cells is unknown. Using a transgenic zebrafish reporter line for the cyclic transcription factor Her1, we recorded single tailbud cells in vitro. We demonstrate that individual cells can behave as autonomous cellular oscillators. We described the observed variability in cell behavior using a theory of generic oscillators with correlated noise. Single cells have longer periods and lower precision than the tissue, highlighting the role of collective processes in the segmentation clock. Our work reveals a population of cells from the zebrafish segmentation clock that behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
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